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Biomedical subjects

M Nobuyoshi

Publications and source records attributed to M Nobuyoshi.

At least 127 records · Page 7Linked to original sources
PubMed1983

Efficacy of isosorbide dinitrate tape on exercise tolerance of patients with angina pectoris.

Evaluation was made on the efficacy of isosorbide dinitrate tape (ISDN tape, TY-0081, Frandol Tape), a preparation newly developed in Japan, regarding the relationship between the exercise tolerance in patients with stable effort angina pectoris and plasma concentrations of ISDN. Placebo(s) or one to three pieces of isosorbide dinitrate tape (10 cm x 10 cm in size, containing 40 mg/tape) were applied to the patients and ISDN plasma concentrations were measured every 6th(15:00) and 24th (9:00) h after each application (9:00). Treadmill tests were repeated for the measurement of exercise tolerance according to a prescribed protocol where the exercise endpoint was the occurrence of chest pain. Correlation was found between the number of ISDN tape applied and the plasma concentrations, as well as between the isosorbide dinitrate plasma concentration and treadmill exercise time in 7 cases out of 10. Exercise time was increased significantly by the application of one piece of ISDN tape or two to three pieces of the tape, compared to the control or placebo study, respectively. The duration of actions lasted more than 24 h. These results suggest the efficacy of ISDN tape on angina pectoris, especially in its durability of action which lasts over 24 h.

Aged↗
PubMed1981

Usefulness of 24-hour recordings of electrocardiogram for the diagnosis and treatment of arrhythmias with special reference to the determination of indication of artificial cardiac pacing.

Twenty-four-hour recordings of electrocardiogram (ECG) were obtained from 1528 subjects. Sick sinus syndrome (SSS) was observed in 34 and advanced or complete AV block (CAVB) in 13 subjects. During the period studied 21 patients had died, who showed complicated ventricular premature contractions in 9 (multiform 6, short run 2, repetitive 2). Seventy-three patients with artificial cardiac pacing who were admitted at three different institutions were analyzed. The discrepancy of degree of block was observed between His bundle electrocardiographic findings and 24-hour ECG recordings. In 15 patients there was no correlation between sinus node recovery time following overdrive suppression and pauses following the termination of tachycardia (r = 0.0896, N. S.). In 49 normal subjects 24-hour heart rate ranged from a high of 170 to a low of 36 beats/min. Longest R-R interval ranged from 2.08 to 0.86 sec (mean 1.25 +/- 0.22 sec). The critical level of longest R-R interval to differentiate between normal group and groups with SSS or CAVB was about 1.6 sec. Above results suggest that Holter monitoring permits a precise diagnosis of arrhythmias and that both HBE and Holter monitoring should be used for the determination of pacemaker implantation especially in those with syncope or dizziness but without evidence of marked bradycardia.

Adolescent↗
PubMed1980

The RSR' pattern in right chest leads in hypertrophic cardiomyopathy: vectorcardiographic analysis.

Vectorcardiogram (VCG) was studied in four patients with hypertrophic cardiomyopathy (HCM) with RSR' pattern in right chest leads. In these patients there ws an anterior QRS loop with a slow inscription in the initial part of the QRS loop, the pathognomonic initial pig-tail curl pattern was also observed in two patients. Though mid-terminal conduction delay was also observed in two patients, the slowly inscribed terminal QRS vector oriented anteriorly and to the right, thus characteristic of right, thus characteristic of right bundle branch block (RBBB), was not observed. The initial conduction delay was attributed to the conduction disturbance as the result of hypertrophy and disarray of the muscle fiber, particularly in the septal area. The recognition of this VCG pattern provides a pertinent clue in the clinical detection of HCM.

Adult↗
PubMed1979

ECG pattern of left ventricular hypertrophy in nonobstructive hypertrophic cardiomyopathy: the significance of the mid-precordial changes.

A review of electrocardiograms from 33 patients with nonobstructive hypertrophic cardiomyopathy was made. In 22 patients there was noted a high QRS voltage, depression of the ST segment, and inversion of the T wave, satisfying the diagnostic criteria of left ventricular hypertrophy with the abnormal changes not only extending to the midprecordial leads but showing the most striking abnormal changes in Lead V4 in 20 patients. The frontal plane electrical axis was normal (around 60 degrees), with the most remarkable changes in Lead II. In the VCG, the magnitude of the QRS loop was increased and directed anteriorly and to the left, and the T loop was deviated posteriorly and to the right opposite the QRS loop. The asymmetric septal and apical hypertrophy was noted on echocardiography and/or angiocardiography. The coronary arteries were normal without significant obstruction in selective coronary angiography. It was postulated that the asymmetric septal and apical hypertrophy was reflected in this ECG pattern. The recognition of this ECG pattern provides pertinent information in the clinical detection of nonobstructive HCM.

Angiocardiography↗
PubMed1978

[Nitroprusside].

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Cardiac Output↗