Biomedical subjects

M Nodarian

Publications and source records attributed to M Nodarian.

6 recordsLinked to original sources

PubMed2002

[Spontaneous clearing of the cornea with detachment of Descemets membrane].

UNLABELLED: Detachment of Descemet's membrane (DM) is a rare complication of cataract and glaucoma surgery. Although permanent corneal edema is the usual outcome of a large detachment, spontaneous clearing of the cornea may occur. CASE REPORT: A 55-year-old man underwent trabeculectomy in 1991 under local anesthesia. One day later the cornea was edematous, with a large superior DM detachment curling inward in the anterior chamber, limited by a thin blood pigmented line. Two months after cornea had cleared, and remained clear for ten years, with 20/20 visual acuity and intraocular pressure of 14mmHg. DISCUSSION: Small detachments of DM after surgery are not rare and usually reattach spontaneously. However, extensive detachment results in overlying corneal edema and may require surgical reapposition. In our case, the cornea cleared spontaneously in the absence of DM repositionning, as denuded corneal stroma may be covered by newly regenerated DM. Before any surgical repair of DM detachment, one should consider spontaneous clearing of the cornea as a possible outcome.

Corneal Diseases↗

PubMed2002

[Idiopathic polypoidal vasculopathy: 2 case reports].

Idiopathic polypoidal choroidal vasculopathy (IPVC), is a particular vascular abnormality of the inner choroid, composed of 2 components, a network of branching vessels of variable dimension, terminating in an aneurysm-like enlargement with sometimes episodic serosanguineous detachment of the retinal pigment epithelium and neurosensory retina. We report two cases of female patients with a peripapillary location of IPVC. None of the eyes had any drusen characteristic of age-related macular degeneration.

Aged↗

PubMed2001

[Capsulorhexis staining by trypan bleu in mature cataract surgery].

BACKGROUND: Capsulorrhexis may be hazardous in the absence of the red fundus reflex. Anterior capsule trypan blue staining enabled to perform the capsulorrhexis and safe phacoemulsification. MATERIAL AND METHODS: Twenty patients with mature cataract were enrolled in the study and opereted on after injection of trypan blue in the anterior chamber. RESULTS: Circular capsulorrhexis was performed in all cases followed by phacoemulsification and in-the-bag IOL implantation. In two cases hard nuclei required a manual extracapsular technique. No operative complications, and no residual of coloration was noted the day after the operation. With a follow-up of 2 to 12 months, no complications appeared (cornea, capsulorrhexis, IOP). CONCLUSION: In mature cataracts, with no red fundus reflex, capsulorrhexis can be done by anterior capsule staining.

Aged↗

PubMed2001

[Clinical course of ocular sarcoidosis in patients with histologically proven systemic sarcoidosis].

PURPOSE: We reviewed the clinical features, natural history and visual prognosis of 9 patients with histologically confirmed ocular and systemic sarcoidosis. PATIENTS: Nine patients underwent a follow-up study between 1993 and 1998. The diagnosis of sarcoidosis was supported by histological evidence of non caseating epithelioid-cell granuloma in tissue biopsy. RESULTS: The mean age was 40.912 years. The mean follow-up was 22.7 months (range 6 - 54 months). The ophthalmic involvement was bilateral in 8 patients. Before treatment, 3 eyes (17.6%) had a visual acuity less than 1/10. Two eyes (11.7%) had a visual acuity less than 3/10 and 10 eyes (58.8%) more than 6/10. The anterior uveitis was granulomatous in 2 eyes (11.7%) and non granulomatous in 8 eyes (47%). Five eyes (29.4%) had a pars planitis. The posterior segment manifestations of sarcoidosis were retinal vasculitis in 7 eyes (41.1%), papillitis in 10 eyes (58.8%) and choroidal granulomas in 2 eyes (11.7%). Seven patients were treated with systemic corticosteroids. One patient was treated with steroid eye-drops. After treatment, one eye (5.8%) had a visual acuity less than 1/10 and 13 eyes more than 6/10. After treatment, the choroidal granulomas disappeared and the intra-ocular inflammation was controlled in all cases. CONCLUSION: Although the number of patients in our series is small, the prognosis for ocular sarcoidosis appears to be good.

Adolescent↗

PubMed2001

[Hereditary hyperferritinemia syndrome and cataract].

UNLABELLED: Hereditary hyperferritinemia cataract is a recently described autosomal dominant syndrome, characterized by bilateral cataracts and elevated level of serum ferritin. PATIENTS: Three members of a family were investigated for cataract and hyperferritinemia. A 30-year-old woman had elevated serum ferritin levels and bilateral cataracts. She was treated for hemochromatosis, but serum iron and transferrin saturation were normal. Her two sons, nine and five years old, also had a high ferritin level and bilateral cataracts. RESULTS: The ferritin level was 1200 micrograms/L in the woman's serum, and respectively, 974 and 965 micrograms/L in the two boys' serum. The mother had a visual acuity of 8/10 in the right eye and 5/10 in the left eye. The cataract comprised fine crystalline cortical opacities, extending axially. The two sons had 7 to 8/10 in both eyes. No other ophthalmic abnormality was noted. These patients were heterozygous for a 16 bp deletion on the L-ferritin gene. DISCUSSION: Ferritin is an iron storage ubiquitous protein present in every cell. In hyperferritinemia cataract syndrome, serum iron and transferrin saturation are normal, and the elevated serum ferritin level is the consequence of an autosomal dominant disorder. The cataract is made up of the accumulation of small opacities disposed radially and more numerous on the outside edges, with relatively good visual acuity. The size of the cataract seems to be correlated to the serum ferritin level. In hemochromatosis, hyperferritinemia is related to increased iron stores and is not associated with cataracts.

Adult↗

PubMedDate not supplied

[Rupture of the hemato-ocular barrier, studied by fluorophotometry, in uveal melanoma patients. Preliminary results].

PURPOSE: To evaluate the use of intravenous vitreous fluorophotometry in assessment of the blood-aqueous barrier in eyes with uveal melanoma. METHOD: Vitreous fluorophotometry was performed before treatment in 14 patients with uveal melanoma. Both eyes of patients were examined, and fifteen control healthy patients were examined between November 1996 and December 1996 at the department of ophthalmology of Bicêtre hospital. RESULTS: Tumors with height > 6 mm and serous retinal detachments were accompanied by marked alterations of the blood-aqueous barrier, vitreous fluorophotometry showed diffusion of dye in posterior, mid and anterior vitreous: 2.99 ng/ml in the posterior vitreous and 5.20 ng/ml in the anterior vitreous. The posterior vitreous fluorescence at 60 minutes in the control eyes was 1.43 ng/ml and 1.30 ng/ml in the anterior vitreous. Diffusion of dye was present in the posterior vitreous in patients with tumor height less than 6 mm: 2.38 ng/ml (1.43 ng/ml in control eyes) at 60 minutes. CONCLUSIONS: Fluorophotometry provides a method for the assessment of the blood-aqueous ocular barrier in eyes with choroidal melanoma.

Aged↗