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M Novák

Publications and source records attributed to M Novák.

252 records · Page 14Linked to original sources
PubMedDate not supplied

Immunodominant structures in the aminoterminal portion of human interferon alpha 1.

The analysis of the antigenic structure of human interferon (IFN)-alpha 1 with a panel of monoclonal antibodies revealed four immunodominant regions. Three of them, recognized by 12 of 14 antibodies were mapped into the aminoterminal portion of IFN-alpha 1 around residues 31-38, 43-53 and 63-85. The region 31-85 proved important also for the antiviral and antiproliferative activity of the IFN-alpha 1 molecule. The antibody recognizing the sequence around residues (54)63-67 also inhibited the cellular binding of IFN-alpha 1 to the high-affinity receptors.

Amino Acid Sequence↗
PubMedDate not supplied

[Isosorbide dinitrate tolerance in the treatment of patients with angina pectoris and the effect of addition of captopril on therapeutic results].

The authors investigated in patients with stable angina the influence of a single dose and of long-term administration of isosorbide dinitrate alone and combined with captopril. Administration of 40 mg Iso-Mack ret. every 8 hours for four weeks did not lead to the development of tolerance. However, captopril added to isosorbide dinitrate tends to improve the investigated indicators after a single dose as well as after long-term treatment. It is probable that concurrent administration of the two drugs causes addition of their vasodilatating action and thus the vascular resistance declines, as well as the cardiac pre-load and after-load and the oxygen consumption of the heart muscle. The authors discuss possible mechanisms of the increased vasodilatation after addition of captopril.

Adult↗
PubMedDate not supplied

[Relation and interactions between the immune and neuroendocrine systems].

For far too long, the immune system has been viewed in isolation from the rest of the body's organ system. But now it is clear that the immune system is an integral part of the organ and physiological systems of whole organism. Especially, the immune and endocrine systems share many ligands and receptors that result in constant and important bidirectional communication. A new and important function for the immune system is to serve as a sensory organ for noncognitive stimuli such as infectious agents and tumours. On the other hand the neuroendocrine system can perform important immunoregulatory activities. It also suggest that brain is not more an immunologically privileged site. Recent studies provide a new view of immunoreactivity to antigens from the nervous system and to immune and inflammatory responses in brain. These may be influenced both by the circulating cytokines derived from the immune system and/or those endogenously produced within the neuroendocrine system. There is a growing body of evidence that cytokines are an integral part of the central nervous system with an important neuromodulatory role in neural mechanisms regulating stress responses, hormonal changes and various kinds of behavior. The mutual informatory circuit inside of the immune, nervous and endocrine systems suggest that they all form the superinformation system with pivotal regulatory role in living organisms. Overall, the recognition of the immune system as our sixth sense may ultimately provide the new understanding of physiology required for successful diagnostic and therapeutic programs against disease and stress involving immune-neuroendocrine communication. (Tab. 5, Ref. 35.)

Animals↗
PubMedDate not supplied

[Infectious diseases of animals and their prevention].

Infectious diseases of animals are the subject of continuous concern. On the one hand there are some diseases which have not yet been described and on the other hand the presence of microbial agents is proved also in diseases which have been considered non-infectious. Undoubtedly, microbes and parasites take part also in the development of malignant transformation of cells. The question of possible transfer of animal oncogenic microorganisms (retroviruses in particular) to humans remains open. The study points to the changes in the incidence of orthopoxviruses which occurred after eradication of human variola and the increasing importance of bartonelloses. Disease prevention in animals is affected to an increasing extent by DNA recombinant methods. So called "Gene farming" has developed, consisting in production of narrow-profile therapeutically important proteins via animal bioreactors. We enter a period in which the resistance of animal organism begins to affect the transfer of genes encoding non-specific and specific protective mechanisms of organisms. (Tab. 7, Ref. 39.)

Animals↗
PubMedDate not supplied

[Prionoses--neurodegenerative diseases caused by prions, offectious proteinaceous molecules].

Prionoses are a group of human and animal neurodegenerative diseases caused by prions, infectious pathogens that differ from bacteria, fungi, parasites, viroids, and viruses. Despite intensive searches over the past three decades, no nucleic acid has been found within prions and considerable experimental data argue that prions are composed exclusively of proteins (glycoproteins). Normal prion protein (PrPC) is encoded by a gene present in all nuclear cells of humans and other mammals but is constitutively expressed mainly in neurons. PrPC is protease sensitive and nonpathogenic but it can be modified to the pathological and protease resistant form designated PrPSC which is essential for infectivity. Prion diseases are manifested as infectious, genetic, or sporadic disorders and are also named as transmissible spongiform encephalopathies (TSE). TSE culminate with a progressive and fatal degeneration of the CNS. The human prionoses include Creutzfeldt-Jakob disease (CJD), kuru, Gerstman-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia (FFI). In mammals, more than 15 different species have been described to suffer from prion disorders till now. Scrapie of sheep and goats is the oldest and the most studied of the prion diseases. Bovine spongiform encephalopathy (BSE) and transmissible mink encephalopathy are thought to result from the feeding of scrapie-infected animal products, whereas BSE has been identified in transmission to mice, domestic cats, two exotic species of ruminant, and monkey. More than 20 cases of clinically and pathologically atypical form of CJD, referred to as "new variant" CJD (vCJD) have been recognized in unusually young people in the United Kingdom. There is a strong evidence that the same prion strain is involved in both BSE and vCJD. It suggest the breaking of species barrier which results by spreading of BSE to humans, putatively by dietary exposure. Understanding the function of prion proteins and their modification to the pathological form may give new insight into the etiologic and pathogenic mechanisms also other diseases caused by aberrant proteins, including Alzheimer' disease, amyotrophic lateral sclerosis, and Parkinson's disease. (Tab. 4, Fig. 3, Ref. 76.)

Animals↗