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Biomedical subjects

M Nuri

Publications and source records attributed to M Nuri.

At least 19 recordsLinked to original sources

[Morphological classification and comparison of the different types of stromal nodules in benign prostatic hyperplasia].

The expression of immunohistochemical markers for cytoskeletal differentiation and that of neuroendocrine- and immunological cells showed in general the same tendency in the 4 types of prostatic stromal nodules: missing or low expression in immature-mesenchymal-, distinct augmentation in fibroblastic-, a maximum in fibro-muscular- and a slight decline in smooth-muscular nodules. These results are in agreement with developmental sequences, revealed by immunohistochemical investigations of fetal prostates, and seem to confirm the hypothesis that the four types of stromal nodules represent successive degrees of maturation, recapitulating ontogenetic processes.

Biomarkers

Cold-induced pulmonary oedema in scuba divers and swimmers and subsequent development of hypertension.

The effect of cold and/or a raised partial pressure of oxygen was examined in eleven people with no demonstrable cardiac abnormality but who had pulmonary oedema when scuba diving or surface swimming, and in ten normal divers. These stimuli induced pathological vasoconstriction in the pulmonary oedema group, nine of whom also showed signs of cardiac decompensation when so stimulated. The pulmonary oedema patients have been followed-up for an average of 8 years. Seven have become hypertensive. Except for the onset of lone atrial fibrillation in one normotensive female diver and development of Raynaud's phenomenon in a normotensive man, there have been no cardiovascular events and no deaths.

Acute Disease

[Mezlocillin versus cefuroxime in urinary tract infections. A multicenter clinical study].

In a multicenter randomised clinical comparative study 96 urological patients with established urinary tract infection were treated in 50% with 2 g mezlocillin three times and in 50% with 1.5 g cefuroxime three times. Both antibiotics were shown to be antibacterially active substances with a high bacterial elimination rate. Three days after cessation of treatment the urine was sterile in 79 cases. Follow-up investigations 1-2 weeks later showed that the number of recurrences and reinfections was higher in the cefuroxime group than in the mezlocillin group. This difference is statistically significant so that mezlocillin can be considered the more effective antibiotic. Clinical and urine cytological results correlated with bacteriological results. Side effects were observed rarely, and toxic effects not at all.

Adult

[Spontaneous regression of pulmonary metastases from hypernephroma: report of a case and review of literature (author's transl)].

Until now there are reported some 60 cases of spontaneous regression of pulmonary metastases from hypernephroma. An own case is shown up: There was taken nephrectomy and following local radiation of hypernephroma in a 59 years old male patient in spite of pulmonary metastases. 8 months after operation these metastases had disappeared. There was no indication for any metastases in radiologic and scintigrafic examination even 4 years following up neither in lungs nor in other organ. The causality of hormones and autoantibodies - perphaps additionally stimulated by wound infection-in the phenomenon of spontaneous regression of pulmonary hypernephroma-metastases is discussed. According to the literature and to experience in an own case nephrectomy and following local radiation - possibly additional progesterone-therapy for one year - is recommended in hypernephroma even in case of pulmonary metastases.

Adenocarcinoma

[Antibacterial therapy of urinary tract infections. Results of a clinical trial with the combination sulfamoxol/Trimethoprim (= CN 3123) (author's transl)].

In the present paper, the use of the combination preparation sulfamoxol/trimethoprim (CN 3123, Nevin [Grünenthal], Supristol [Nordmark]) in urinary tract infections is reported. This preparation was used in 165 patients of both sexes and all ages. The initial dose was 2 tablets followed by a maintenance dose of 1 tablet every 12 hours for a treatment lasting 10 days on the average. The preparation led to asepsis in 69% of the patients with chronic urinary tract infections if the organisms were sensitive in vitro. In asymptomatical urinary tract infections complicated by fistula and transurethral indwelling catheters, on the other hand, elimination of organisms was only attained in 46%. In our opinion, antibiotic therapy is not indicated in these patients only after taking off the indwelling catheter.

Adolescent

[Indanyl Carbenicillin in the treatment of urinary tract infections due to difficult urological organisms (author's transl)].

Fifty in-patients suffering from chronic urinary tract infections with underlying urological diseases received the oral Carbenicillin preparation Indanyl Carbenicillin (short term Carindacillin) for 10 days in a dosage of 1 g q.i.d. The therapy results were objectified by blood and urine tests performed prior to and after treatment. Indanyl Carbenicillin led to a sterile urine in nearly 60% of the patients; in about 85% of the cases the primary organism was eliminated. The drug was particularly active against difficult organisms such as Proteus, Klebsiella and Pseudomonas. The results obtained in this study are somewhat surprising as the dosage used produces bactericidal levels of the active substance only in the cavity system of the efferent urinary tract but not in the tissue. No effect on blood picture or liver function was observed. Side effects occurred in 8 patients, they disappeared with continued therapy or after discontinuation of the drug. Considering the good efficacy observed in this study and because of the possibility of oral administration, Indanyl Carbenicillin appears to be suitable also for out-patient treatment of chronic urinary tract infections due to difficult urological germs.

Administration, Oral