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Biomedical subjects

M O Korhonen

Publications and source records attributed to M O Korhonen.

10 recordsLinked to original sources
PubMed1988

Endocervical brush cytology. An alternative to endocervical curettage?

The usefulness of an endocervical brush for cytologic sampling was studied in 288 consecutive women attending a colposcopy clinic. One hundred sixty had initial colposcopic examinations with directed biopsies and endocervical curettage (ECC). One hundred twenty-eight had follow-up examinations that included Papanicolaou smears and ECC some time after evaluation and/or treatment for cervical dysplasia. Within an established protocol for the evaluation and management of abnormal Papanicolaou smears, the endocervical brush was compared to ECC. When the combination of colposcopy and cervical conization showed that dysplasia was confined to the endocervix, the endocervical brush was significantly more sensitive than ECC in detecting this endocervical disease (P less than .05). In follow-up evaluations and in patients with unsatisfactory colposcopic examinations, endocervical brush cytology could replace ECC without affecting clinical management. In patients with a satisfactory colposcopic examination, ECC may be required only when endocervical brush cytology is abnormal. Endocervical brush cytology is less costly and painful and could prove to be a reasonable alternative to ECC for the initial evaluation of the endocervix. Endocervical brush cytology shows promise as a safe adjunct to the colposcopic evaluation of pregnant women, whereas ECC is contraindicated in such women.

Adenocarcinoma↗
PubMed1984

Adenocarcinoma of the uterine cervix. Prognosis and prognostic significance of histology.

Corrected survival rates for 163 cases of adenocarcinoma of the uterine cervix at 5 and 10 years were 51% and 42%, respectively. For clinical Stages I to IV the 5-year survival rates were 71%, 40%, 30%, and 0%, respectively. The frequency of positive lymph nodes was 4% in Stage I and 71% in Stage II adenocarcinomas. For Stage II this figure is much higher than usually reported in squamous cell carcinoma, and suggests that these tumors behave differently. No significant difference in survival rate was found between pure adenocarcinoma, adenosquamous carcinoma, clear cell adenocarcinoma and adenocarcinoma. Histologic grade showed a direct correlation to the survival rate; for grade I tumors it was about 60%, whereas for patients with grade IV tumors only about 10% survived.

Adenocarcinoma↗
PubMed1982

Development of clear cell adenocarcinoma in DES-exposed offspring under observation.

Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in utero to diethylstilbestrol are reported. One patient, aged 23, had been followed for 2 years before carcinoma was diagnosed; the second patient, aged 22, had been seen on a regular basis for 5 years, 8 months. In both instances, suspicion of the presence of carcinoma was aroused by the palpation of a small nodule in the vaginal fornix. Hysterosalpingography was performed on both patients and, in 1 instance, an abnormal x-ray film was reflected by the gross appearance of the uterine cavity found in the surgical specimen.

Adenocarcinoma↗
PubMed1982

Carcinoma in situ of the vulva. The search for viral particles.

Biopsy specimens taken from eight women with squamous-cell carcinoma in situ of the vulva were studied with transmission electron microscopy for the presence of viral particles. In one of the specimens a 150-nm-diameter viruslike particle was found. The exact nature of this particle was not clear, but it could have represented an immature herpesvirus particle. In seven specimens no evidence of viral particles was detected. These findings provide further evidence that the positivity of vulvar carcinoma in situ for herpesvirus antigen is not due to the presence of whole virus particles.

Adult↗
PubMed1981

Herpesvirus-induced antigens in squamous-cell carcinoma in situ of the vulva.

Antigens induced by herpes simplex virus Type 2 (HSV2) were found to be associated with squamous-cell carcinoma in situ of the vulva in nine of 10 patients. The HSV2-induced antigens are DNA-binding proteins that are normally present in the nuclei of infected cells, but in the cells of the carcinomas in situ they were found in the cytoplasm. Whole-virion structural antigens were not present, although there was serologic evidence of previous HSV2 infection in patients tested for the presence of antibodies. The observations reported here and the recent parallel rise in the prevalence of both HSV2 infections and vulvar carcinoma in situ, particularly in women under 40 years of age, suggest an association of HSV2 infection with this type of neoplasia, the nature of which remains to be determined.

Adult↗
PubMed1975

Multiple repeat caesarean sections on one patient.

A case history is presented of a patient with 8 consecutive caesarean sections over 1965--1973. Total hysterectomy was performed during the last section because of thinned uterine wall, marginal placenta praevia and heavy bleeding. The aspects of repeated caesarean sections are discussed in the light of the present case.

Adult↗