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M O Scase

Publications and source records attributed to M O Scase.

5 recordsLinked to original sources
PubMed1992

Detection of colour vision abnormalities in uncomplicated type 1 diabetic patients with angiographically normal retinas.

Colour vision function was assessed in 38 non-complicated type 1 diabetic patients in whom fluorescein angiography was normal, and was compared with that in 36 age-matched, non-diabetic controls. All of the patients were healthy and none were taking medication except insulin. The eye examination, which was normal in every patient, included the Ishihara and City University tests, measurement of Snellen acuity, slit-lamp examination, tonometry, and fundal photography as well as fluorescein angiography. Colour discrimination ability was measured with the Farnsworth-Munsell 100-hue test. Mean (SE) 100-hue test error score for the diabetic group was 86.8 (8.1) compared with 28.2 (3.3) for controls, p<<0.001. There was no relation between colour vision abnormalities and diabetes duration (r = 0, p>0.05), blood glucose at the time the colour tests were performed (r = 0.4, p > 0.05), most recent glycated haemoglobin result (r = 0.3, p>0.05), or the mean of all previous glycated haemoglobin results (r = 0, p>0.05). It is concluded that colour discrimination may be abnormal in uncomplicated type 1 diabetic patients before the onset of retinopathy, and that colour discrimination losses in diabetes may not be of vascular aetiology.

Adult↗
PubMed1990

Visual loss in multiple sclerosis and its relation to previous optic neuritis, disease duration and clinical classification.

Visual function was investigated in a group of 58 clinically classified cases of multiple sclerosis (MS). Psychophysical measures of luminance and chromatic threshold sensitivity and temporal contrast sensitivity were undertaken, together with visual evoked potentials and Bjerrum screen perimetry. The patient group was divided on the basis of optic neuritis (ON), clinical disease duration and clinical classification. A comparison of the results of all visual measures suggested a nonuniform loss of function in the patient group without ON and a more consistent loss of function in the group with ON. The various measures were equally efficient in detecting abnormal function, albeit from different areas of the central visual field. Clinical disease duration was not a significant independent factor in predicting visual dysfunction. In contrast, a comparison of clinical classification categories revealed significantly fewer abnormalities of visual function in the suspected MS category (31%) than in the ON, early probably and clinically definite categories (75-100%), a result which indicated the importance of clinical classification as a predictor of visual dysfunction.

Adult↗
PubMed1988

Anomalous loss in blue-green wavelength discrimination with very brief monochromatic stimuli presented to the normal human eye.

The wavelength-discrimination curve of the normal human eye shows minima in discrimination thresholds at about 490 and 580 nm for viewing times of 1 s or longer. A reduction in viewing time was found to yield non-uniform increases in discrimination thresholds in the blue-green region of the spectrum, and these findings were quantified in objective, two-interval, forced-choice discrimination measurements. Monochromatic stimuli were presented foveally in a circular, horizontally oriented, bipartite field of 100 Td and angular subtense 2 degrees. When viewing time was decreased to 3 ms there was a sharp increase in discrimination threshold over 490-520 nm, maximizing near 500 nm. In this region, the fields appeared markedly desaturated. The loss in discrimination was distinct from that exhibited by tritanopes, and a control experiment showed that the effect was not attributable to the reduced energy of the short flash.

Adult↗
PubMed1987

Isolation of opponent-colour mechanisms at increment threshold.

An experimental examination was made of some paradigms designed to isolate the opponent-colour system at increment threshold. The effectiveness of a uniform white conditioning field spatially coincident with a 1.05-deg uniform test field was assessed by measuring intensity thresholds for simple detection and for colour discrimination. Values were obtained both by a method of adjustment and by a two-interval forced-choice procedure. For sufficiently high luminances of the conditioning field (3000 td or greater) little or no difference was found between simple-detection and colour-discrimination thresholds over the critical test-flash spectral range 520-620 nm, implying that the paradigm produced almost complete isolation of the opponent-colour system at increment threshold. A control experiment in which thresholds were obtained for a conditioning field larger than the test field gave less satisfactory isolation; near 580 nm the luminance system was found to be at least 0.3 log unit more sensitive than the opponent-colour system. A comparison was also made of the spatially coincident field paradigm with a paradigm in which a modified test stimulus of low temporal and spatial frequency content was presented on a large conditioning field. Test spectral sensitivity curves for simple detection obtained by a method of adjustment showed little difference in effectiveness in opponent-colour isolation.

Adult↗