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Biomedical subjects

M O'Boyle

Publications and source records attributed to M O'Boyle.

30 records · Page 2Linked to original sources

Panic disorder: diagnosis and treatment.

Panic disorder is an important entity for primary care physicians to be aware of, as patients with panic disorder often present with physical complaints and may be misdiagnosed as having a somatization disorder or hypochondriasis. While the latter disorders are difficult to treat, panic disorder is well suited to treatment using the traditional medical model. This article describes suggested evaluation of suspected panic disorder and outlines treatment strategies. While tricyclic antidepressants, monoamine oxidase inhibitors, and alprazolam are all effective antipanic agents, tricyclic antidepressants are suggested as the medication of first choice. Treatment failures most often result from an inadequate medication trial (ie, trial too brief or dosage inadequate); with adequate treatment most patients with panic disorder can be helped.

Alprazolam↗

Premenstrual syndrome and locus of control.

Seventy-six women completed a three-month prospective evaluation for premenstrual syndrome (PMS). As a part of the evaluation, they completed Rotter's Locus of Control (LOC) form in the follicular phase and premenstrually. It was found that the LOC scores of women meeting criteria for PMS rose significantly (became more "external") premenstrually, while scores of women without PMS did not show significant change. In addition, the premenstrual LOC scores of women meeting criteria for PMS were significantly higher than were scores of the non-PMS women. The results are consistent with the idea that cycle related changes in self-perception occur in women demonstrating PMS symptomatology.

Adult↗

Suicide attempts, substance abuse, and personality.

The prevalence and relevance of a positive suicide attempt history among 103 subjects who had entered a substance abuse program and participated in a study of personality was examined. Twenty subjects had a positive suicide attempt history. Women were more likely to attempt suicide. Attempters were more likely to have additional psychiatric diagnoses, such as major depression. Attempters had higher addiction severity scores, abused more substances, and were more likely to have abused alcohol and sedative hypnotics than were nonattempters. DSM-III-R and Eysenck personality measures were compared across groups. Attempters had significantly higher neuroticism and borderline scores. Impulse dysregulation may predispose this group to more severe addictions.

Adult↗

'Don't know' responses in elderly demented and depressed patients.

The suggestion that patients having depression with reversible dementia make more "don't know" responses to cognitive questions than do demented patients was tested. Inpatients were administered the Mini-Mental Status Examination (MMSE) on admission and shortly before discharge. Errors and "don't know" responses were recorded. Groups were defined as (1) demented (n = 20; diagnosis of dementia, entrance and exit MMSE less than 24) and (2) depressed with reversible dementia (DRD, n = 11; diagnosis of major depression, entrance MMSE less than 24, exit MMSE greater than 24, delta MMSE greater than 3). Groups differed significantly on MMSE scores and errors, with demented patients scoring lower and making more errors than the DRD group. Groups did not differ significantly in "don't know" responses. Comparisons between groups on sections of the MMSE showed that demented patients scored significantly lower and made more errors than DRD patients only on the orientation section of the MMSE. The results suggest that DRD patients do not make more "don't know" responses than demented patients; however, demented patients make more errors on orientation questions.

Age Factors↗