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Biomedical subjects

M Oettel

Publications and source records attributed to M Oettel.

At least 91 records · Page 5Linked to original sources
PubMed1978

[Postcoital contraception in primates. I. Action mechanism of a potential postovulatory fertility-inhibiting substance STS 456 in the baboon (Papio hamadryas)].

With the substance STS 456, an estrogenic active steroid, a high fertility inhibition could be obtained in the pavian, when administered p. o. over a 5 day period postcoital. The effectiveness and also the side effects were dose dependent. The antifertility mechanism is based on an luteolytic effect, demonstrated by analytical hormonal investigations. The inhibition of the synthesis of steroids in the ovary affected not only progesterone but also the estrogens.

Animals↗
PubMed1978

Influence of 3-methylether of ethinylestradiol (Mestranol) on oviductal egg transport in rats.

The development of fertilized eggs and their transport through the oviduct were studied in rats treated orally with 3-methylether of ethinylestradiol (mestranol) at a single administration in different doses. The ED50 values were in the same range (0.11--0.34 mg mestranol/kg b.w.) as well in postcoital pregnancy inhibition test as in the experiments on tubal egg contents on day 3 as in implantation sites in niagara blue test on day 6. This suggests that the uniform cause of pregnancy inhibition of postcoital mestranol treatment on day 1 in rats is the acceleration of tubal egg transport. The ED50 of mestranol given on day 1 shortened the stay of eggs in tubes to 24 hours. Mestranol dosage above the ED50 reduced the tubal stay towards two days in comparison to five days in control animals. The number of eggs prematurely expelled from the tubes into the uterus was relatively high on day 2 and 3 in animals treated with mestranol in high dosage and with ligated cervix, compared with animals without ligation. But on day 4 on blastocysts were found. This result shows that the prevention of pregnancy is caused by the expulsion of blastocysts from uterus and/or the degeneration of zygotes in utero. Blastocysts or morulae recovered from treated rats in high dosage were transferred to the uteri of pseudopregnant recipients: 29% developed into normal term foetuses compared to 29 or 30% for both untreated control groups.

Animals↗
PubMed1977

Influence of intragastrically administered androgens on hypothalamic differentiation in rats.

Male and female rats aged 3 days were injected intragastrically with methyltestosterone and STS 383 synthetic androgen in doses between 0.4-3.2 mg and 0.2-3.2 mg, respectively. The treated females showed disturbances in hypothalamic differentiation as demonstrated by changes of the day of vaginal opening and frequency of oestrus, by a decrease of ovarian weight and a loss of fertility. It is thus possible to investigate perorally active aromatizable androgens for their central activities. STS 383, a new p. o. active androgen showed a higher activity compared with methyltestosterone in this study, whereas in the Hershberger model methyltestosterone was previously found to be 4 times more active than STS 383. A possible dissociation of central and peripheral activities between these two substances is discussed.

Androgens↗
PubMed1977

Androgen-dependent fighting behaviour in male mice.

The influence of testosterone propionate, 17 alpha-methyl-testosterone and cyproterone acetate on isolation induced fighting behaviour of mice was studied in a simple testing procedure. Decreased aggressiveness has been established in mature, sexual experienced and isolated male mice both following castration and administration of the antiandrogen cyproterone acetate, respectively. Replacement therapy with testosterone propionate s.c. and 17 alpha-methyl-testosterone p.o. has been shown to restore the decreased level of aggresiveness after castration.

Aggression↗
PubMed1976

[Endocrinologic and pharmacologic-toxicologic findings with ethinyl-estradiol sulfonate. 8th communication. Complement and lysozyme in the serum of beagles after 6 months application of ethinylestradiol sulfonate].

In course of studies for the chronic toxicity of estrogens after oral application two parameters of the unspecific resistance - complement (CH50U and CB50U) and lysozyme - in sera of 30 beagle-dogs were studied. The doses of the daily (over 6 months) applicated hormones were 1,0 mg/kg ethinylöstradiol and 1,0, 0,1 and 0,01 mg/kg ethinylöstradiolsulfonate (depotform). In the majority of all measurements no significant variations of serum complement and -lysozyme could be detected, however after application of high doses of the hormone ethinylöstradiol a little reduction of complement and significant elevations of lysozyme were observed.

Animals↗
PubMed1974

[Effect of long-term application of SUISYNCHRON-premix on swine].

Two groups of five female store pigs, weighing an average of 60 kg at the start of the experiment, were given either 1 or 10 mg metallibure zinc complex (SUISYNCHRON) per kg body weight once daily for six months, in the form of a 2% talcum premix added to concentrates. Clinical inspection, weight gain, haematological findings, blood sugar, serum transaminases, properties of urine and faeces, carcass examination and histological study (internal organs, endocrine glands, skeletal muscle) showed that the 1 mg/kg dosage had no toxic effect. The 10 mg/kg dosage resulted in considerable depression in appetite and some apathy in the pigs, but there was no evidence of a toxic effect.

Alanine Transaminase↗
PubMed1974

[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHROM. 2. Toxicologic findings].

Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.

Acute Disease↗