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Biomedical subjects

M Ohgami

Publications and source records attributed to M Ohgami.

40 records · Page 3Linked to original sources
PubMed1989

Kinetics of radiolabeled neutrophils in swine.

The kinetics of radiolabeled neutrophils (PMNs) as they pass through the lungs of swine were evaluated and compared with those in rabbits (J. Appl. Physiol. 63: 1806-1815, 1987) and dogs (J. Appl. Physiol. 63: 1253-1261, 1987; 65: 1217-1225, 1988) previously reported from our laboratory. 111In-labeled PMNs (111In-PMNs) and 99mTc-labeled erythrocytes were simultaneously injected into the right atrium, and the 111In-PMN percent extraction on the first passage through the lung was determined by the indicator-dilution technique. After 10 min of circulation the distribution of 111In-PMNs in selected organs was determined. The extraction of 111In-PMNs in swine was 88 +/- 3%, which was significantly greater than that of rabbits (78 +/- 3%) or dogs (72 +/- 2%). The recovery of the 111In-PMNs in the lungs of swine was 60 +/- 7%, which was two to three times higher than the recovery in lungs of rabbits or dogs. These results show that radiolabeled PMNs injected intravenously are less able to pass through the pulmonary vasculature and are retained much more within the lung in swine than in rabbits or dogs. This difference could be the result of the presence of pulmonary intravascular macrophages in the lungs of swine.

Animals↗
PubMed1987

A massive dose of vincristine.

An esophageal cancer patient with bilateral lungs and neck lymph nodes metastases received 24 mg of vincristine instead of vinblastine because of the similarity between the two names, and survived multiorgan derangement. Serious states of central and peripheral neuropathy with muscle atrophy, gastrointestinal disorder, bone marrow suppression and mucocutaneous involvement were all encountered. Although hypotension and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) were not observed as vincristine's side actions, toxicity to the myocardium, which has not been documented, was suggested in our case. These toxic impairments, however, subsided clinically within a month, except for paresthesia in the peripheral extremities. The effectiveness of the chemotherapy was remarkable against both the esophageal cancer and the metastatic lesions. No unintentional overdose of a drug, needless to say, should happen, and in order to minimize its possibility, it would be advisable for chemotherapy to be administered only by an experienced physician who is able to check the dose and concentration.

Adult↗