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Biomedical subjects

M Ohishi

Publications and source records attributed to M Ohishi.

At least 163 records · Page 9Linked to original sources
PubMed1985

Secondary correction of the cleft lip and nose deformity: a new technique for revision of whistling deformity.

Reconstruction of the continuity of the orbicularis oris is the main component in correction of the whistling deformity. However, many of the cases are associated with other deformities, such as conspicuous lip scars, an unnaturally wide central lip, flaring alae with wide nostril floors, and a short columella with a flat nasal tip. We report a technique that combines correction of such deformities with reconstruction of the orbicularis oris in a single operation.

Adolescent↗
PubMed1984

Population and family studies of HLA in Japanese with cleft lip and cleft palate.

Population and family studies of HLA were performed in Japanese patients with cleft lip and/or cleft palate (CL/P). Frequency of HLA-Cw 7 was significantly increased in cleft lip (CL) patients (37.5%) and cleft palate (CP) patients (37.8%) but was not increased in cleft lip and palate (CLP) patients (17.5%), compared with control subjects (13.3%). However, the intensities of the associations were not great (relative risk = 4.0). The affected sib pairs method was studied in 13 families with CL- or CLP-affected sib pairs and 10 families with CP-affected sib pairs. However, in both groups of families the distributions of HLA haplotypes in affected sib pairs did not significantly differ from random Mendelian expectation. Thus, HLA-linked major genes (loci) which determine the development of CL/P were not found. These results seem indirectly to support the multifactorial theory of CL/P, but does not exclude other possible genetic mechanisms.

Cleft Lip↗
PubMed1983

First branchial cleft anomaly and congenital aural sinus--a case report.

A case of first branchial cleft anomaly is reported. The case presented classical signs and symptoms and further had a family history of congenital aural sinuses through 3 successive generations. Clinical features of the patient are briefly described and the embryological relationship between first branchial cleft anomaly and congenital aural sinus is discussed.

Abnormalities, Multiple↗
PubMed1983

T cell-activating monokines in guinea pigs: comparison of high and low molecular weight factors.

Guinea pig monokines produced by lipopolysaccharide-stimulated peritoneal macrophages were found in high (50,000-80,000) and low (10,000-30,000) molecular weight (m.w.) fractions by gel filtration. Both showed enhancing activity on the proliferative response of guinea pig and mouse thymocytes to PHA, but the high m.w. (65K) monokine was much more efficient than the low m.w. (15K) monokine in enhancing the response of lymph node T cells to PHA, suggesting its importance in the activation of peripheral T cells. The 65K monokine was coeluted with BSA present in the culture medium by DEAE-cellulose chromatography, but was clearly separated from it by hydroxylapatite chromatography. The immunoadsorption experiment with anti-BSA-coupled gel also indicated that 65K monokine is not a complex of low m.w. monokine with BSA. Our series of studies showed that most monokine activities were always found in the 65K fraction in guinea pigs. Thus, in guinea pigs, the 65K component appears to constitute a major class of T cell-activating monokines.

Animals↗
PubMed1982

HLA-DR antigens in Japanese with Hashimoto's thyroiditis and Graves' disease.

HLA-A, -B, -C and -DR specificities were determined to study the association of HLA in 49 unrelated patients with Hashimoto's thyroiditis and 51 patients with Graves' disease. The results were compared with 144 control subjects from the Japanese population at large. Much less HLA-DR2 was found in the patients with Hashimoto's thyroiditis than in the normal controls. It was present in 16% of the thyroiditis patients compared to 39% in the controls. Also the frequency of HLA-DRl was less in the patients with Graves' disease (0%) than in the controls (15%). No positive association was found for any HLA-antigens in the two diseases.

Asian People↗
PubMed1981

[Pathogenesis and behavior of invasive mole without preceding hydatidiform mole (author's transl)].

From 89 cases of invasive mole, collected by our department since 1948, 12 (13.5%) cases without preceding hydatidiform mole (group A) were taken out, and their clinical data and histological observations were studied in comparison with those preceded by hydatidiform mole (group B) in the remaining 77 (86.5%), with the following results: 1. Invasive mole in group A was preceded by artificial or spontaneous abortion, but not by premature or normal delivery. 2. All of the 12 cases developed the invasive mole within 6 months. 3. Relation between the size of the focus and the latency period was not observed in either of the two groups. 4. The incidence of preoperative metastasis was somewhat lower in group A, but no difference was visible between the two groups in prognostic result. 5. As for histological findings, edematization and vesiculation of stroma of villi were observed in all the cases of group A, though with difference in grade from case to case. These findings as well as proliferation and intervascular penetration of villous cells were similar to those of group B.

Abortion, Induced↗