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Biomedical subjects

M Ohmae

Publications and source records attributed to M Ohmae.

At least 37 records · Page 2Linked to original sources
PubMed1982

Effects of doxorubicin (adriamycin) on systemic hemodynamics and myocardial blood flow.

The effect of adriamycin (doxorubicin) on systemic hemodynamics was assessed in the anesthetized rabbit. Blood flow was measured by the radioactive microsphere method before and 20 min after adriamycin. Cardiac output and stroke volume fell significantly (p less than 0.05), while myocardial blood flow as a proportion of cardiac output and systemic vascular resistance rose significantly (p less than 0.05) after adriamycin. Systemic arterial blood pressure, heart rate, and total myocardial blood flow were not significantly altered. Thus, in the intact animal, adriamycin decreases cardiac output but not at the expense of coronary blood flow.

Animals↗
PubMed1982

Antiarrhythmic effects of cyclic guanosine 3' :5'-monophosphate and sodium nitroprusside on barium chloride arrhythmias in rabbits.

The hypothesis that c GMP and sodium nitroprusside (NP), an activator of guanylate cyclase which elevates levels of c GMP, have antiarrhythmic activity was tested in the barium chloride (BaCl2) model of arrhythmias. Electrocardiograms were recorded continuously on tape in unanesthetized New Zealand white rabbits weighing approximately 2.0 kg. BaCl2, 4 mg/kg i.v. bolus, induced frequent ventricular ectopic beats. These ventricular arrhythmias were abolished by 8-bromo-c GMP, 5 mg/kg, injected into the left ventricle (5/6 rabbits), NP 25.0 microgram/kg/min i.v. (6/6), NP 10 micrograms/kg/min i.v. (3/6), and markedly reduced in frequency by NP 10 micrograms/kg/min (3/6). In temporal association with NP, 4 fold increases in c GMP levels in blood and significant increases in myocardial GMP were found compared to control animals (n = 6). In this model, c GMP and NP have significant antiarrhythmic properties. NP effect may be mediated by alterations in c GMP metabolism.

Animals↗
PubMed1981

Hyperkalemia-induced bundle branch block and complete heart block.

Hyperkalemia was associated with complete heart block in one patient that resolved by first showing right anterior hemiblock). Then the right bundle branch block resolved, leaving the marked left axis deviation that was present before the hyperkalemic episode. Another patient with hyperkalemia had right bundle branch block with marked left axis deviation, both of which disappeared with correction of the hyperkalemia. These findings suggest that hyperkalemia can depress conduction in the His-Purkinje system and raise the possibility that hyperkalemia may induce complete heart block distal to the atrioventricular junction.

Aged↗
PubMed1979

Electrophysiologic and pathologic correlations in six cases of atrioventricular block.

1) A prolonged A-H interval suggested A-V nodal involvement. 2) A prolonged duration of the His potential suggested moderate His bundle involvement. 3) Complete block distal to H appeared to reflect total disruption of both bundle branches. 4) The lesion at the penetrating portion of the His bundle could be responsible for A-H block. 5) A-H block occurred in a case of cellular infiltration in the A-V node and the His bundle, in which bilateral bundle branch showed severe fibrosis. 6) A combination of right bundle branch block, marked left axis deviation and H-V prolongation suggested trifascicular disease. 7) In case 6, there was a severe pathologic lesion at the origin of the left bundle branch, yet left bundle branch block was not indicated electrocardiographically. This study revealed a close correlation between electrophysiologic and pathologic findings in 4 out of 6 cases.

Aged↗
PubMed1977

Correlative studies on electrocardiogram and histopathology of the conduction system. (1) Right bundle branch block with left axis deviation and prolonged P-R interval.

The conduction system was examined histologically in three cases whose electrocardiograms showed right bundle branch block and left axis deviation with or without PR prolongation. In two cases histological lesions were found in the right bundle branch and anterior division of the left bundle branch. In the third case histological lesions were found in the right bundle branch and anterior and posterior divisions of the left bundle branch. This case sufferred an Adams-Stokes attack. In the two patients with right bundle branch block and left axis deviation with PR prolongation, the PR prolongation was attributed to delay in atrioventricular node or His bundle in one case and to delay in left bundle branch in the other.

Adams-Stokes Syndrome↗
PubMed1976

Paroxysmal atrial fibrillation with asystole and syncope: report of a case of sinus node dysfunction with hypokalemia and hypertension.

A patient is presented who developed syncope due to asystole following paroxysmal atrial fibrillation. Suppression of intrinsic cardiac pacemakers during tachycardia is postulated as the mechanism for asystole. This patient might have sinus node dysfunction. The episodes of tachycardia occurred more often when the serum potassium level was low.

Arrhythmias, Cardiac↗