Biomedical subjects

M Onofriescu

Publications and source records attributed to M Onofriescu.

4 recordsLinked to original sources

PubMedDate not supplied

[The diagnosis of gestational diabetes].

Diabetes mellitus complicates 2 to 3 per cent of all pregnancies and 90 per cent of these women have gestational diabetes mellitus (GDM)--the most common complication seen in obstetrical practice today. It occurs in the second half of pregnancy and is usually asymptomatic. It is recommended that all pregnant women to be screened by administering a 50 g oral glucose load followed by a glucose determination 1 hour later. The test may be performed at 24 to 28 weeks' gestation in the fasting stage. A 1-hour test value of 140 mg/dl (7.8 mmol/l) or more indicates the need for a 3-hour 100 g glucose tolerance test (GTT). The patient must have a normal fasting value and two abnormal GTT glucose determinations to be designated as GDM. Early detection and management are important to prevent complications to mother and fetus. Patients with GDM represent a group at significant risk for developing glucose intolerance later in life.

Adult↗

PubMedDate not supplied

[Cervical pregnancy].

The authors report a case of cervical pregnancy in a nulliparous woman (after treatment for secondary infertility) treated systemically and locally with methotrexate. Related to the case, they make some considerations concerning early diagnosis and conservative treatment of ectopic cervical pregnancies, in order to maintain the patients' fertility. The woman presented in this case report is now 5-weeks intrauterine pregnant.

Abortifacient Agents, Nonsteroidal↗

PubMedDate not supplied

[Scintigraphy in breast cancer].

Scintigraphy was evaluated in comparison to clinical and paraclinical methods used in diagnosis of breast tumors. 32 patients with palpable breast tumors were investigated by clinical examination, ultrasound, mammography and scintigraphy. Different radiopharmaceuticals marked with 99mTc were used, having different affinity for the tumoral tissue. A Siemens Diacam gamma camera was used. Patients were submitted to dynamic study of early blood-pool and tissular phase, followed by late static incidences. Regions of interest were compared with similar areas of the contralateral breast. Conclusions were compared to histopathological diagnosis. We have calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for each of the investigation methods. The sensitivity was 80% for clinical examination, 100% for ultrasonography, 66% for mammography and 100% for scintigraphy. The specificity was 77% for clinical examination, 50% for ultrasonography, 90% for mammography and 80% for scintigraphy. PPV was 75% for clinical examination, 60% for ultrasonography, 80% for mammography and 82% for mammography. NPV was 82% for clinical examination, 100% for ultrasonography, 71% for mammography and 100% for scintigraphy. Good correlation was found between scintigraphy and histopathology. Ultrasound and mammography also confirmed, in most cases, the clinically suspected diagnosis. Including scintigraphy in the investigation protocol for breast tumors will allow a better assessment of the therapy.

Adult↗

PubMedDate not supplied

[New endometrial ablation techniques in the treatment of dysfunctional uterine bleeding].

Endometrial resection is a well-examined alternative therapy to hysterectomy in the treatment of abnormal uterine bleeding not associated with malignancy, that preserves the uterus at long term in at least 70% of patients. The new devices have been designed over the last decade, in response to demands from patients and practitioners. This review demonstrated that the second generation endometrial ablation techniques provide efficient and apparently safe endometrial ablation, are quicker to perform, and some may be more suitable for office treatment without the need for anesthesia, are simple to use and less skill dependent, and can, in properly selected cases, provide good results. Preprocedure counseling of patients, including the expected postoperative course and the known procedural risks, is important for adequate informed consent.

Catheter Ablation↗