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Biomedical subjects

M Orbetsov

Publications and source records attributed to M Orbetsov.

At least 19 recordsLinked to original sources
PubMed1990

[Results of the long-term observation and treatment of patients with arterial hypertension].

48 patients, 40 men (mean age 57.4 years) and 8 women (mean age 56.7 years) with stable arterial pressure--II B and III stage according to A. L. Miasnikov's classification, were treated and followed up dynamically in the course of 8 years. The treatment with diuretics, beta-blockers and reserpin has led to a permanent and satisfactory regulation of arterial pressure in most of the patients. Only in 10.4% of the patients the therapeutic results were not satisfactory. In spite of the normalization of the arterial pressure the number of patients with various forms of ischemic heart disease is high--79.2%. The risk factors and their combinations play an important role for this condition (diabetes mellitus, gout, obesity, lipid metabolism changes, etc.). These data imply a new assessment of the drugs used in the treatment of arterial hypertension.

Antihypertensive Agents↗
PubMed1983

[Effect of the use of lidocaine on patients with acute myocardial infarct].

In 411 patients with acute myocardial infarction (AMI) the effect of intravenous lidocaineeee administration was studied in a suboptimal dose - under 1,5 mg/min (to 1979) and in the optimal dose - over 1,5 mg/min, minimum 2 mg/min during the first 12 hours, with an average 24 h dose, 3,0 g in the course of 48 hours. The patients were grouped into three prognostic groups, depending on their initial assessment according to the coronaryprognostic index of M. R. Norris (1969). The indices, via which the drug effect was determined; were 13, the more significant ones beind: ventricular arrhythmias, early lethality rate, postinfarction angina pectoris and regression fo lesion-ischemic ST-T alterations. It was established, after the analysis of the data obtained, that the prophylactic and therapeutic use of lidocain, considerably reduced the incidence of ventricular arrhythmias in patients with AMI. Lidocain, in an optimal dose, reduces the incidence, justifying its routine administration. Lidocain effect on ventricular arrhythmias, the early lethality rate and certain complications (postinfarction angina pectoris, early cardiac insufficiency, regression of ST-T alterations) in AMI, depend on the initial prognosis and the stage of the hemodynamic disorders.

Adult↗
PubMed1981

[Clinical dynamic ECG observations of the physical load tolerance of myocardial infarct patients].

Dynamic ECG observations are reported after a full day interval motor programme, applied with four motor regimes on patients with myocardial infarction under clinical conditions. The motor programme was used for the treatment of 241 patients, distributed into 2 groups. Observation on the effect of peak physical loading at the end of each motor regime was also reported. The authors concluded that the tolerance to physical loading was adequate, being confirmed by the absence of significant ECG dynamics even with the peak loadings, performed at the end of all motor regimes.

Adult↗
PubMed1981

[Alpha cholesterol in ischemic heart disease and myocardial infarct].

Alpha-cholesterol is one of the risk factors for the manifestation of myocardial infarction. The authors examined 48 patients with ischemic heart disease, complicated with myocardial infarction, 28 males and 20 females, aged from 40 to 60, treated at the Clinic of Cardiovascular Diseases with Intensive Unit, RIID--Med. Academy. Ninety three control subjects were examined for a comparison--43 males and 50 females, aged from 40 to 60. Lower alpha-cholesterol values were found in the patients with myocardial infarction. Those data coincide with the communications in literature. Alpha-cholesterol reduction could be assessed as an indirect risk factor of a atherosclerosis, ischemic heart disease resp.

Adult↗
PubMed1979

[Changes in the serum level of prekallikrein and kallikrein inhibitor activity in ischemic heart disease].

The authors studied the changes in four indices of kalikrein-kinine system. For that purpose 80 patients were examined, subdivided into the following groups; 1) hypertonic disease -- I -- II and II stage -- 20 patients; 2) myocardiosclerosis -- 20 patients; 3) unstable stenocardia -- 20 patients; 4) myocardial infarction -- 20 patients. The results obtained are compared with the results of the control group of 20 healthy subjects. The method of Colman and collaborators, modified by Veremeenko and collaborators was used for the quantitative determination of prekalikrein and kalikrein inhibitors. The data obtained suggest an enhanced kalikrein activity, very likely kinine as well, i.e. -- stimulation of kalikrein kinine system in IHD patients, determined by the increased formation and decreased inactivation of the enzyme (kalikrein).

Adult↗
PubMed1978

[Clinical trial of the preparation clofazolin used intravenously].

The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.

Adolescent↗
PubMed1978

[Sick sinus node syndrome and the transitory collapse of the R wave in myocardial infarct].

The authors observed 40 patients (7.79%) with the morbid sinus node syndrome among the treated 526 patients with acute myocardial infarction at the department of intensive care during the period 1973--1976. Thirty one were males and nine--females. The syndrome was manifested, in all patients followed up, during the first 14 days after the onsed of the coronary incidence. One case was with a lethal end. Ten patients (1.90%) were observed with the syndrome "transitory collapse of R-deflection" in the separate precordial leads. Half of them had a combination of both syndromes. The collapse of R-deflection was manifested between the 3rd and 14th day in all cases. The character and incidence of rhythm-conductivity disturbances accompanying both syndromes are discussed.

Acute Disease↗
PubMed1978

[Changes in uricemia in acute myocardial infarct].

The authors studied in dynamics the concentration of uric acid in 84 patients in the acute stage of myocardial, in 28 patients with non-stable stenocardia. The average value of uricemia, in the first 1--2 days post infarction is 6.35 +/- 2.23 mg%, considerably higher than that in case of non-stable stenocardia--4.75 +/- 1.25 mg%. In all the patients with myocardial infarction, 34.04 per cent have uricemia over 6 mg% (upper limit of the norm). The hypouricemia was normalized by the 14--15 day after the onset of infarction--4.25 mg%. The highest values of uric acid (up to 13 mg%) were found in case of severely progressing infarctions. A parallelism was established between serum concentration of uric acid and the creatinine-phosphokinase level. The possible pathogenic mechanisms of hyperuricemia in the acute stage of myocardial infarction are discussed.

Acute Disease↗
PubMed1977

[Effect of Production on the serum lipid and lipoprotein level in ischemic heart disease].

The serum lipids were dynamically followed up in 39 patients with ischemic heart disease treated with Prodectin. A gradual decrease of serum cholesterin is observed during the treatment period as well as of its content in alfa lipoproteins and of alfa lipoproteins themselves. A moderate decrease of triglyceride and total lipids develops in parallel with this, whereas free fatty acids considerably increase. In more than 1/3 of the patients the profile of hyperlipoproteinemia changed in the course of the treatment: the half of them turned to normolipoproteinemia, a number of the rest--into a more favourable type--II and IV type.

Adult↗