[Plasma cortisol. Hepatic function and atopic dermatitis].
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Adolescent↗
Biomedical subjects
M Orea
Publications and source records attributed to M Orea.
[Frequency of urticaria and angioedema induced by food additives].
Certain food additives are known to induce urticaria and angioneurotic edema in susceptible patients. Thirty-three patients with chronic urticaria and angioneurotic edema whose case history suggested a possible link between exacerbations of the symptoms and ingestion of food additives or with acute exacerbations of the disease without any known triggering event were challenged orally in a double-blind study with increasing doses of the following additives: sodium benzoate, sodium metabisulfite and tartrazine and lactose as placebo. Ten of the 33 patients (30.3%) were intolerant to at least one compound. Among 132 oral provocation tests 11 (8.3%) were positive (appearance of acute urticaria/angioneurotic edema): 5 (15.1%) to sodium benzoate, 4 (12.1%) to tartrazine an 2 (6%) to sodium metabisulfite. There was no reaction to placebo and no serious reaction was observed. Under the conditions used, oral provocation tests proved to be feasible, safe and useful in the routine investigation of chronic urticaria and angioneurotic edema.
Adolescent↗
[Transference factor in moderate and severe atopic dermatitis].
We did a prospective, comparative, experimental study with 30 patients with moderate to severe atopic dermatitis from the allergy section from September 1994 to March, 1995. The test laboratory examination was performed in all patients: complete blood cell count, immunoglobulins A, G, M and E determination, lymphocyte subpopulations CD3, CD4, CD8, CD4-CD8 proportion, CD25, rosette formation for B and T lymphocytes, coproparasitoscopic examination, throat and nose cultures, nasal cytology, skin tests of cellular immunity to PPD, thrichophytin, candidine, varidasa; skin prick test to poliens, fungi, inhalants and foods. All patients underwent to a sign and symptom grading score system as follows: the parameters were erythema, pruritus, eczema, papule valorated on a scale from 0 a 4+( O = no symptoms, + = mild, ++ = moderate, + ++= severe, ++ ++ = very severe). Initially all patients received one placebo unit every 15 days orally 3 times, then one after 30 days. Laboratory examination was performed and then treatment with transfer factor was initiated, initially 1 unit every 15 days three times and the fourth 30 days after. 15 days after the last dose a new immunological valoration was done. Results demonstrate a CD4 cell decrement, blood eosinophil and lgE dissemination although they're not statistically significative. There was a statistically significative improvement in the 4 clinical parameters: erythema, eczema, pruritus and populous with the use of Transfer Factor.
Adjuvants, Immunologic↗