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Biomedical subjects

M Orea Solano

Publications and source records attributed to M Orea Solano.

35 records · Page 2Linked to original sources
PubMedDate not supplied

[Efficacy and safety of fexofenadine and cetirizine in the treatment of allergic rhinitis].

BACKGROUND: Allergic rhinitis affects 20 million of people in United States and a higher figure all around the world. OBJECTIVE: To evaluate the efficacy and safety of fexofenadine compared with certirizine in the treatment of allergic rhinitis. MATERIAL AND METHOD: It was carried out a prospective, double blind, comparative, randomized and multicentric study in patients with allergic rhinitis, with ages between 12 and 65 years. In the first phase, placebo was administered during three days to all the patients; and then, they were randomly allocated to receive fexofenadine 120 mg or cetirizine 10 mg in one dose a day during 14 days. Laboratory and cabinet tests at the beginning and at the end were performed to value security, as well as a global evaluation of the researcher to estimate effectiveness. RESULTS: 176 patients were included, 63.6% were women, average age was 27 years (+/- 12), 47.7% received fexofenadine and 52.2%, cetirizine. There was not significant difference in parameters of effectiveness nor of security in the studied group. CONCLUSION: The results of the present study confirm the efficacy and safety of the antihistaminic fexofenadine in the treatment of allergic rhinitis.

Adolescent↗
PubMedDate not supplied

[Transfer factor as specific immunomodulator in the treatment of moderate-severe atopic dermatitis].

BACKGROUND: Atopic dermatitis is a skin inflammatory disease which has been associated to high levels of IgE, eosinophiles and change of T lymphocytes. The transfer factor is an immunomodulator active substance and decreases the number of inflammatory cells and the severity of the symptoms of atopic dermatitis. OBJECTIVE: To determine the efficacy of the transfer factor as treatment of moderate and severe atopic dermatitis. MATERIAL AND METHODS: Articles related to treatment with transfer factor in the atopic dermatitis were looked up in Medline and EMBASE, and the ones referring to controlled studies in patients with moderate and severe atopic dermatitis in accord to SCORAD. RESULTS: We found seven articles with 121 patients and 88 controls demonstrating significant decrease in the symptoms of the SCORAD index, decreased IgE, and eosinophils in patients treated with transfer factor. CONCLUSIONS: The transfer factor is a choice treatment for moderate and severe atopic dermatitis.

Dermatitis, Atopic↗
PubMedDate not supplied

[Safety and efficacy of specific sublingual immunotherapy in patients with asthma and allergy to Dermatophagoides pteronyssinus].

BACKGROUND: First reports on sublingual immunotherapy were published in 1980. OBJECTIVE: To compare safety and effectiveness of sublingual immunotherapy, as compared with placebo, in asthmatic patients. MATERIALS: In a blinded randomized controlled trial asthmatic patients with positive skin prick tests to Dermatophagoides pteronyssinus, and with serum IgE at least 200 UI were included. According to GINA, asthma severity was mild persistent and moderate. All patients improved their baseline FEV1 at least by 14% after inhaled albuterol. Spirometry was performed again after three and six months after initiating treatment. Patients were randomized to receive for six months either sublingual immunotherapy with Der p 1 standardized allergens (IPI-ASAC, México) at a total dose of 10,469 UBE or identically looking and tasting placebo. Both groups received conventional pharmacological therapy. RESULTS: Sixty four patients enter the study; four were excluded because of systemic oral steroid therapy. Sixty patients underwent randomization. Both groups (30 patients in each one) were similar in their baseline characteristics. After six months, patients that received sublingual immunotherapy had less exacerbations than those in the control group (61 vs 123, T 2.61, p<0.001, IC 1.8-7.2), better FEV1 as compared with baseline values (25% vs 9%, Z=0.66, p=0.03), and less need of albuterol (50% of initial dose, vs 21% (Z=1.4, p=0.03, IC 1.39-1.49). CONCLUSION: Sublingual immunotherapy improves patient symptoms and pulmonary functional tests, makes exacerbations less frequent, and reduces albuterol needs. It may improve asthma related quality of life.

Administration, Sublingual↗
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[Electrocardiographic changes with the use of aminophylline and salbutamol in adult patients with chronic bronchial asthma].

Fifteen patients diagnosed with bronchial asthma were examined to evaluate the cardiotoxicity caused by the combined intravenous treatment using methylxanthine-aminophylline 250 mg and a beta agonist: salbutamol 0.5 mg. The following observations were made: four patients had sinus tachycardia and another suffered from ventricular extrasystoles as seen in the electrocardiographic register; another two patients had sinus tachycardia when the bronchial dilator dosage was doubled. From a clinical and electrocardiographic standpoint, arrhythmias do not seem to be a grave problem among the population studied.

Adult↗
PubMedDate not supplied

[Ebastine vs terfenadine in allergic rhinitis].

A prospective, comparative, random study was conducted with 40 patients treated with ebastine vs. terfenadine. The purpose of the study was to evaluate the efficacy of both as second generation antihistamines used in the treatment of allergic rhinitis. Ten milligrams of ebastine was administered once a day before breakfast (fasting), in 5 and 10 year old children and 20 mg in 11 to 15 year olds. Ebastine was more efficient in the control of symptoms (rhinorrhea, nasal obstruction, sneezing, eye and nose itching) than terfenadine from the seventh day on, (p 0.05). Tolerance to ebastine was good, although a small number of patients (1.5%) suffered collateral symptoms: sleepiness, headaches and nausea. The two doses of ebastine (10 or 20 mg depending on the patients age) had overall efficacy rates better than terfenadine (p 0.05%).

Adolescent↗
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[Correlation between the concentrations of total serum IgE and skin tests].

An investigation was done to know IgE levels and prick skin test correlation in 300 patients with allergic rhinitis and extrinsic bronchial asthma groups to IgE levels. Correlations themselves contribute to variability index in 15.6% and diagnosis sensitivity in 0.86. We concluded that study (IgE levels) is and indispensable test for atopic patient.

Adolescent↗
PubMedDate not supplied

[Pilomatrixoma (calcified epithelioma of Malherbe). Report of a case and brief review ot the literature].

A case of a upper extremity pilomatrixoma (calcifying epithelioma of Malherbe) clinically confused with a secondary reaction to the dog antigen application presented in a young woman and diagnosed following surgically excised is presented. On cytologic examination, basaloid cells, multinucleated giant cells and deposits of calcium were identified. Adjacent to the basaloid cells were acellular masses suggestive of ghost cells.

Adult↗
PubMedDate not supplied

[Tryptase: a diagnostic marker in allergic diseases].

Mast cells play a central role in allergic diseases, following activation by means of immunologic mechanisms. Mast cell degranulation releases preformed and newly generated mediators and potential indicators of mast cell activation. Tryptase is the most useful marker of selective mast cell activation with regard to specific pathological states in which it can be applied with positive results, especially allergic diseases.

Animals↗
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[Comparative study of prick and intradermal cutaneous tests in allergic rhinitis].

A prospective clinical study to compare the skin prick test method e intradermal method as a diagnostic tool in allergic rhinitis: There were 100 patients with allergic rhinitis of both sexes in the study with ages ranging from 3 to 18. All of them received skin tests by the prick method to 10 common pollen extracts in Mexico City. If the patient showed positively was included in the control group, and if negative the intradermal method to the same extracts was performed. The intradermal method was utilized in 50 patients, of which only 12 (24%) showed positivity to the tests. This result doesn't showed a significant difference with the prick method, with a value of p greater than 0.05.

Adolescent↗
PubMedDate not supplied

[Immunogenetic study in a case of DiGeorge syndrome].

DiGeorge Syndrome is a congenital immunodeficiency characterized clinically by hypocalcemic tetany, congenital heart disease, unusual facies, and increased susceptibility to infection. Pathologically, the syndrome is marked by the abscence or hipoplasia of the thymus and parathyroid glands as well as cardiac or aortic arch abnormalities. Most patients show partial or complete T cell immunodeficiency and normal or near-normal B-cell immunity. A review is made on a clinical case of DiGeorge syndrome is presented. A 52 days old boy, was admitted through emergency. There was no familial evidence of alcoholism or immunodeficiency. He showed irritability due to hypocalcemia. The examination revealed facial and cardiovascular abnormalities and the immunological investigation revealed hypogammaglobulinemia, deficiency of the cell, CD4 and CD8 decreased and with inverted relation. Chest X ray showed cardiomegaly grade II, and no thymus was seen. The diagnosis of the complete DiGeorge syndrome was based on the abnormalities found.

Abnormalities, Multiple↗
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[Efficacy of a new in vitro test (Phadiatop paediatric) for the diagnosis of allergy in children].

An investigation was done to know specificity and sensitivity of one in vitro test useful for diagnosis of allergy in pediatric age (Phadiatop paediatric), in 65 children in two groups. Group 1 (35 children) with diagnosis of respiratory allergy (asthma, rhinitis, or both) based on clinical history, eosinophils, IgE and skin tests; and group 2 (control) with no allergy diagnosis. In both groups IgE was measured and Phadiatop test was done. In group 1, Phadiatop paediatric was positive in 28 children (80%) while in group 2 was positive in 2 children (6.6%) that means a 67.5% sensitivity and 88.0% specificity, for this test.

Allergens↗
PubMedDate not supplied

[Macrophages in asthma].

Every time they exist more demonstrations of the paper than performs the line monocytes-macrophage in the patogenesis of the bronchial asthma. The mononuclear phagocytes cells, as the alveolar macrophages, also they can be activated during allergic methods. The monocytes macrophages are possible efficient inductors of the inflammation; this due to the fact that they can secrete inflammatory mediators, between those which are counted the pre-forming granules of peptides, metabolites of oxidation activation, activator of platelets activator and metabolites of the arachidonic acid. The identification of IL-1 in the liquidate of the bronchial ablution of sick asthmatic, as well as the identification of IL-1 in the I bronchioalveolar washing of places of allergens cutaneous prick, supports the activation concept mononuclear of phagocytic cells in allergic sufferings.

Asthma↗