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M Oresic

Publications and source records attributed to M Oresic.

4 recordsLinked to original sources
PubMed2000

2,8-Dihydroxy-1,3,7,9-tetramethyl-6,12-dihydrodipyrido

The 2,8-dihydroxy-1,3,7,9-tetramethyl-6,12-dihydrodipyrido[1,2-a:1', 2'-d]pyrazinediylium dication possesses 2/m symmetry and lies in the mirror plane together with a chloride anion and the water O atom. The dication also lies on an inversion centre, i.e. C(16)H(20)N(2)O(2)(2+).2Cl(-).2H(2)O. Due to these symmetry constrictions the dication adopts an unexpected planar conformation. Molecules are linked by O-H.O and O-H.Cl hydrogen bonds to form chains, which are cross-connected by C-H.Cl attractive interactions forming a complex three-dimensional hydrogen-bond network.

Journal Article↗
PubMed1998

Specific correlations between relative synonymous codon usage and protein secondary structure.

We found significant species-specific correlations between the use of two synonymous codons and protein secondary structure units by comparing the three-dimensional structures of human and Escherichia coli proteins with their mRNA sequences. The correlations are not explained by codon-context, expression level, GC/AU content, or positional effects. The E. coli correlation is between Asn AAC and the C-terminal regions of beta-sheet segments; it may result from selection for translational accuracy, suggesting the hypothesis that downstream Asn residues are important for beta-sheet formation. The correlation in human proteins is between Asp GAU and the N termini of alpha-helices; it may be important for eukaryote-specific sequential, cotranslational folding. The kingdom-specific correlations may reflect kingdom-specific differences in translational mechanisms. The correlations may help identify residues that are important for secondary structure formation, be useful in secondary structure prediction algorithms, and have implications for recombinant gene expression.

Bacterial Proteins↗