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Biomedical subjects

M Ors

Publications and source records attributed to M Ors.

6 recordsLinked to original sources

The N400 component in parents of children with specific language impairment.

Children with specific language impairment (SLI) often have a family history of language disorder. In this study, ERPs in response to a visual semantic priming task were recorded in parents of children with SLI. Despite equal performance, the ERPs displayed differences in language processing: larger N400 amplitudes indicated that the parents, especially the fathers, were less primed by the preceding context. Difference waveforms showed that the fathers of SLI children, contrary to controls, had less differentiated responses to congruent versus incongruent sentences. We propose that the N400 observations may be residual markers of past language deficiencies in the fathers. No differences in the N400 effect were found in the mothers of SLI children.

Adult↗

Event-related potential findings in healthy extremely pre-term (< week 29) children at age 10.

Ten healthy extremely pre-term (EPT) children, born before gestational week 29, were tested at age 10 using mismatch negativity (MMN) and a three-tone odd-ball task; the results were then compared to age-matched full-term controls. We found no difference in MMN. By contrast, EPT children had generally shorter N1 latencies and larger P2 amplitudes, possibly indicating a more stimulus-driven response mode. However, P300 parameters, indicative of controlled attention, were unaffected.

Brain Damage, Chronic↗

The role of catecholamines in the control of gastrin and acid secretion during insulin hypoglycaemia in man.

5 adrenalectomized subjects and 8 healthy volunteers underwent an insulin test during which acid secretion and plasma adrenaline, noradrenaline, dopamine and gastrin concentrations were measured. Plasma glucose concentration fell by greater than 50% in all subjects. The mean plasma adrenaline concentration increased markedly (greater than 1,000%) in the normal group but was unchanged in the adrenalectomized group. In all subjects, plasma noradrenaline concentration increased moderately, whereas plasma dopamine levels remained unchanged. Clear-cut increments in plasma gastrin concentration were seen only on 3 participants, each of whom responded to insulin hypoglycaemia with an extremely high adrenaline release. Basal and peak acid output were similar in adrenalectomized and normal subjects. The results suggest that circulating catecholamines contribute to the control of gastrin and acid secretion in man only during circumstances with high plasma catecholamine levels, e.g. severe stress.

Adult↗