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Biomedical subjects

M Oyarzabal

Publications and source records attributed to M Oyarzabal.

9 recordsLinked to original sources
PubMed2002

[Hypogrowth. General considerations].

Growth is a basic indicator of the state of health of a child. Many pathologies that occur during childhood can have an incidence and affect final height in an evident way. The evolution and periodic follow up in the examination of the health of height and weight is a compulsory control for paediatricians, who must detect early alterations that might correspond to responsible pathologies and make possible a correct diagnosis and treatment as early as possible. The time of growth in the life of a person is not long, and the importance of a careful follow up derives from this. In this paper we review the factors that interact in growth, the methodology to follow in primary health consultation in order to establish a diagnosis, and the follow up when dealing with a low height. We include the classification of growth retardation that makes it possible to differentiate the low height denominated idiopathic from the pathological.

English Abstract↗
PubMed1998

Multicentre survey on compliance with growth hormone therapy: what can be improved?

A survey was undertaken to evaluate compliance in Spanish patients receiving growth hormone treatment. The 28-item structured questionnaire was designed to collect data on compliance, treatment schedule, device used and instruction received. In total, 473 questionnaires were completed in 17 paediatric endocrine units. Compliance was divided into four categories based on percentage of doses omitted, classified as excellent if 0%, good <5%, fair 5-10% and poor >10%. The level of compliance was excellent in 74.0%, good in 20.1%, fair in 3.4% and poor in 2.5%. Compliance was better in those who injected themselves (p < 0.01), were trained by hospital staff (p < 0.01) and used automatic pens (p < 0.05). Patients using conventional syringes were less likely to comply (p < 0.05). More information on growth hormone treatment was requested by 57.6% of patients. The results indicate that the specialist nurse should spend sufficient time with the patients and relatives to ensure a higher compliance rate.

Adolescent↗
PubMed1997

Nocturnal hypoglycaemia in IDDM patients younger than 18 years.

The present multicentre study was undertaken to assess the prevalence of nocturnal hypoglycaemia and its determining factors in 117 diabetic children and adolescents, aged 2-18 years and diabetes duration > 1 year in Spain. Each child made 3 measurements of blood glucose (BG) at home at night (between 0000 h and 0600 h) on nine separate nights. A hypoglycaemic event occurred in 12-14% of children in any one night. This is lower than rates for nocturnal hypoglycaemia reported in literature, perhaps because of relatively late mealtimes and different meal content, in Spanish children. Children aged < 7 years were at higher risk of nocturnal hypoglycaemia than older children (p < 0.05). Mean HbA1c from the year before the study and mean HbA1c measured during the closest time to the study were significantly lower in those with nocturnal hypoglycaemia (p < 0.0001). Blood glucose concentrations 2 h before hypoglycaemia did not predict nocturnal hypoglycaemia. The occurrence of low or very low blood glucose concentrations before breakfast was related to a higher risk for nocturnal hypoglycaemia (chi 2 22.97; p < 0.001). No previous symptoms were detectable in 89% of cases.

Adolescent↗
PubMed1997

Incidence of type I diabetes mellitus in Navarre, Spain (1975-91).

The aim of this study was to ascertain the incidence of Type 1 diabetes mellitus in Navarre, an autonomous community in northern Spain. Subjects were patients who presented with diabetes between 1975 and 1991, age range 0-16 years, resident in Navarre at the onset of symptoms. Endocrinologists in outpatient centres and hospitals (both public and private) in Navarre were the primary source of data, while secondary sources were: independent general practitioners, health centre paediatricians and the Child-Youth Diabetics Parents' Association of Navarre. The degree of ascertainment was 97.8%. Average annual incidence of diabetes detected was 9.54/100000 (95% CI 8.2-11.1) in the 0-14 year-old group. The least incidence was observed in 1976 and highest in 1990. The incidence in males (9.71/100000) was higher than in females (7.83/100000). The highest incidence was observed in the 10-14 year-old group (13.70/100000) when analysed by groups. No seasonal variation in the onset of diabetes was observed. These results suggest a significant increase in the incidence of type 1 diabetes between 1975 and 1991.

Adolescent↗
PubMed1993

[A system of efficient appointments for interviewing persons over 65].

OBJECTIVE: To validate an appointment system which leads to a high compliance of people over 65 invited to attend an interview. DESIGN: A descriptive observational study of a crossover type, between February and June 1990. SETTING: Primary Care; community activity. PATIENTS OR OTHER PARTICIPANTS: A representative sample of the population over 65 registered at the Cuenca 1 Health Centre, selected by means of systematic sampling. MEASUREMENTS AND MAIN RESULTS: Personal letters, signed by the patients' own doctor, to make the appointment. If they did not attend, a second appointment was made by 'phone when possible or by letter if not. The overall reply was 73.79% (221 after the first appointment call and 55 after the second). 8.29% did not wish to carry out the interview; 12.30% were not located; 3.48% were incapacitated and 2.14% had died or were no longer registered at the centre. CONCLUSIONS: The following all favour the level of response: the personalized invitation, signed by the patient's doctor, stating the day and time; carrying out the interview at their Health Centre or home; and making a second appointment where necessary. At the same time these measures contribute to bringing our records up-to-date.

Age Factors↗
PubMed1985

[Trisomy 9p. Apropos of 2 cases].

Two cases of trisomy 9p are presented. The different cytogenetic mechanism given in these cases shows us that with independence of it, it exists a triplication of the half distal short arm of chromosome 9 which gives specificity to these phenotypic features. It might be a possible meiotic origin of the chromosomic rearrangement on both translocations, the formation of satellited chromosomes and isochromosomes of the short arm on chromosome 9 and the consequently wrong segregation of each one of them. The non-existence of chromosomic material with activity in the transcription, confers to both situations the category of a pure trisomy 9p. The prenatal diagnosis through amniocentesis might be useful, even in the so called "de novo" cases, in order to avoid the repetition of this kind of structural aberration or some others that could appear due to fragility of certain chromosomic regions.

Chromosomes, Human, 6-12 and X↗