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Biomedical subjects

M Ozgen

Publications and source records attributed to M Ozgen.

5 recordsLinked to original sources
PubMed2001

Spinal cord injury caused by gunshot wound during pregnancy.

We report a case of a pregnant woman with acute spinal cord injury (C5) caused by gunshot wound and discuss the respective maternal and fetal considerations. Neither decompressive surgery nor corticosteroid protocols were used. At 37 weeks, the patient delivered a normal female infant after induction of labor and epidural anesthesia, with no medical or obstetrical complications. With conservative management and rehabilitation, this patient had significant recovery of function.

Adult↗
PubMed1997

Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant.

Phospholipid signaling mediated by lipid-derived second messengers or biologically active lipids is still new and is not well established in plants. We recently have found that lysophosphatidylethanolamine (LPE), a naturally occurring lipid, retards senescence of leaves, flowers, and postharvest fruits. Phospholipase D (PLD) has been suggested as a key enzyme in mediating the degradation of membrane phospholipids during the early stages of plant senescence. Here we report that LPE inhibited the activity of partially purified cabbage PLD in a cell-free system in a highly specific manner. Inhibition of PLD by LPE was dose-dependent and increased with the length and unsaturation of the LPE acyl chain whereas individual molecular components of LPE such as ethanolamine and free fatty acid had no effect on PLD activity. Enzyme-kinetic analysis suggested noncompetitive inhibition of PLD by LPE. In comparison, the related lysophospholipids such as lysophosphatidylcholine, lysophosphatidylglycerol, and lysophosphotidylserine had no significant effect on PLD activity whereas PLD was stimulated by lysophosphatidic acid and inhibited by lysophosphatidylinositol. Membrane-associated and soluble PLD, extracted from cabbage and castor bean leaf tissues, also was inhibited by LPE. Consistent with acyl-specific inhibition of PLD by LPE, senescence of cranberry fruits as measured by ethylene production was more effectively inhibited according to the increasing acyl chain length and unsaturation of LPE. There are no known specific inhibitors of PLD in plants and animals. We demonstrate specific inhibitory regulation of PLD by a lysophospholipid.

Journal Article↗
PubMed1994

Supernumerary molars and paramolars.

Thorough X-ray examination is a valuable adjunct in the clinical assessment of supernumerary teeth. Three cases of supernumerary teeth comprising paramolars and molars are presented with radiographic documentation. All the patients received surgical treatment after full clinical and radiographic evaluation.

Adolescent↗
PubMed1990

Orthodontic application of proximal clasps.

Removable plates are widely used for various purposes in orthodontics. In order to accomplish the designed treatment objective, it is necessary to provide sufficient retention of the removable appliance. In this regard, clasps such as Adams, Schwarz, Arrowhead, Duyzing, Jackson, Crozat, ball, triangular, c and so on, have been developed. Furthermore, as much importance must be given to the level of comfort provided by the clasp as is given to its retentive property, particularly in appliances where long-term wear is essential. With regard to these two properties, proximal clasps render the greatest contribution through their high retentive capacity and ease of placement in the mouth. Hence, in spite of being developed originally for dentures, these clasps may be accommodated effectively in orthodontic appliances. In this paper, experiences acquired through practical application of proximal clasps are presented.

Adolescent↗