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Biomedical subjects

M Ozsan

Publications and source records attributed to M Ozsan.

11 recordsLinked to original sources
PubMed2000

Vacuolating cytotoxic activity of 40 Helicobacter pylori strains isolated from Turkish patients.

In this study we examined the in vitro vacuolating cytotoxic activity of Helicobacter pylori, which is a gram-negative microaerophilic curved bacterium and a causative agent of gastritis, peptic ulcer and gastric ulcer. A vacuolating cytotoxin assay was performed to assess the vacuolating activity of 40 strains (20 gastritis, 11 gastric ulcer, and 9 duodenal ulcer), which were obtained from patients undergoing upper gastrointestinal endoscopy. The Vero cell line was used in the cytotoxic assay. Of the 40 isolates, 24 (12 gastritis, 6 gastric ulcer, 6 duodenal ulcer) were cytotoxic for the Vero cell line at 1:4 and 1:8 dilutions. Thus, vacuolating cytotoxin of H. pylori affects the Vero cell line, but it seems there is no correlation between the positivity of the strains and the risk of any particular H. pylori disease.

Animals↗
PubMed2000

Chlamydia and atherosclerotic coronary arterial disease in Turkey.

OBJECTIVE: Chlamydia pneumoniae, which is a Gram(-) intracellular bacteria, besides being a respiratory pathogen, is thought to play an active role in the progress of acute myocardial infarction and chronic coronary artery disease. In this study we aim to determine the frequency of C. pneumoniae in coronary artery lesions of Turkish people. METHODS AND RESULTS: The atherosclerotic material taken from 8 cases by directional atherectomy and from 23 cases by surgical endarterectomy and examined by indirect immunofluorescence (IIFA) test and polymerase chain reaction (PCR). C. pneumoniae positivity was 32.3% (10/31) by IIFA and 29.0% (9/31) by PCR while the evaluation of the methods together yield a positivity of 35.5% (11/31). CONCLUSIONS: A statistically significant difference could not be established between C. pneumoniae positive and negative groups according to age and the classical atherosclerotic risk factors such as diabetes mellitus, smoking, hypercholesterolaemia, hypertension, family history; besides, a statistically significant difference could not be found between the presence of C. pneumoniae and the severity and clinical picture of coronary artery disease.

Chlamydia Infections↗
PubMed1993

[In vitro susceptibility to cefoperazone and sulbactam/cefoperazone combination of bacterial strains isolated from various patient materials].

Susceptibility of 110 bacterial strains isolated from clinical materials to Cefoperazone (CPZ) and Sulbactam/Cefoperazone (SBT/CPZ) combination was investigated and every strain was examined for beta-lactamase activity. Total beta-lactamase positivity rate was 40.9%. Antibacterial activity of SBT/CPZ combination was found to be higher than CPZ alone, especially on beta-lactamase producing bacteria.

Bacteria↗
PubMed1989

[Antibacterial sensitivity of Staphylococcus aureus isolated from clinical specimens].

In this study we evaluated the susceptibility of Staph. aureus to antibacterials in vitro by disk diffusion technique. 393 staph. aureus strains isolated from various clinical samples at the Bacteriology laboratory of Ankara University Medical Faculty Microbiology Department. As a result, the most effectual antibacterials are in order: Cefotaxime, Cefuroxime, Cephalothin, Ceftazidime, Sulbactam, Erythromycin, Kanamycin, Tetracycline, Clindamycin, Vancomycin, Thiamphenicol, Methicillin, Penicillin G.

Anti-Bacterial Agents↗
PubMed1989

[Isolation of beta-hemolytic streptococci from throat and nasal swabs and their antibiotic susceptibility].

1218 throat and 888 nasal swabs were collected from non hospitalized patients were examined for beta haemolytic streptococci. The samples were cultured on blood agar. To facilitate the isolation of beta haemolytic streptococci the samples were also cultured on biologically anaerobic sheep blood agar. From throat swabs and nasal swabs 174 and 13 beta haemolytic streptococci were isolated respectively. 113 beta haemolytic streptococci were identified as a group A (60%). In this study we evaluated the antibiotic susceptibility of streptococci. As a result the most effective antibiotics are in order Cefuroxime, Cefotaxime, Cephalothin, Thiamphenicol, Erythromycin.

Anti-Bacterial Agents↗
PubMed1983

[Antistreptolysin--O titers in normal persons].

ASO titers were determined 120 normal persons from different age groups. The mean titer was estimated as 160,37 +/- 14.08 Todd units. Only % 20 of normal individuals have had a titers over 200 units.

Adolescent↗