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Biomedical subjects

M P Anand

Publications and source records attributed to M P Anand.

At least 19 recordsLinked to original sources

Prevalence of hypertension amongst Mumbai executives.

OBJECTIVE: To find out prevalence of hypertension amongst Mumbai executives. METHODS: Data of annual medical check-up of 1653 executives was evaluated. Blood pressure was measured as per JNC VI/WHO guidelines. RESULTS: Overall prevalence of hypertension amongst Mumbai executives was 26.86%. 21.28% of executives who were hypertensive based on causal reading were later found to have normal or high normal blood pressure. CONCLUSION: For all epidemiological surveys, blood pressure must be recorded on at least two subsequent occasions after initial screening.

Blood Pressure Determination↗

Non-pharmacological management of essential hypertension.

Lifestyle modifications are universally accepted, not only as the first step in the management of hypertension but also a way to prevent hypertension. The INTERSALT study of 52 communities worldwide showed that weight, among all measured characteristics except age, had the strongest, significant, most consistent and independent correlation with blood pressure. INTERSALT epidemiological data had demonstrated a positive association between sodium intake and level of blood pressure. A rigorous analysis of 23 randomly controlled trials showed that 100 mmol/day reduction in sodium intake was associated with a decline of 5-7 mm Hg (systolic)/2.7 mm Hg (diastolic) in hypertensive subjects. Excessive alcohol consumption is another important risk factor for hypertension and has been reported to account for 5-30% of all hypertension. Moderately intense exercise at 40 to 60% of maximum oxygen consumption e.g., 30 to 45 minutes of brisk walking on 4-5 days a week, can lower blood pressure. The incidence of stroke and coronary artery disease in hypertensive patients who smoke is 2-3 times greater than in non-smoking patients with comparable blood pressure and stopping smoking rapidly reduces this risk. There have been several studies showing the stress reduction with various behavioural procedures, such as yoga, relaxation biofeedback, transcedental mediation and psychotherapy benefit hypertensive patients by lowering their blood pressure.

Alcohol Drinking↗

Smoking and hypertension: Indian scenario.

In a large multicentre study of 918 hypertensive patients, 28% of subjects were found to be smokers. Smokers had a higher average weight and associated diseases like coronary artery disease and diabetes. It is suggested that higher incidence of coronary artery disease and diabetes in the hypertensive smokers carries a higher risk of further cardiovascular events.

Adolescent↗

Cold weather and myocardial infarction.

We studied 1217 cases of myocardial infarction, admitted to Patna Medical College Hospital, Patna, during the period 1979 to 1983, and correlated the incidence of the disease with air-temperature, seasons and months. There was no monthly variation in the incidence of the disease. The seasons similarly had no influence on incidence. The frequency of myocardial infarction, however, was significantly higher when the minimum air-temperature was 16 degrees C or less (P less than 0.001). This study indicates that drop in atmospheric temperature below a certain level directly increases the incidence of myocardial infarction and suggests simple prevention measures against the adverse effect of cold.

Cold Temperature↗

Effect of labetalol and propranolol on human cutaneous vasoconstrictor response to adrenaline.

Using half-life disappearance of intradermally injected radioiodine as a parameter for cutaneous blood flow, a study was made of the effects of labetalol and propranolol on the vasoconstrictor response to adrenaline at environmental temperatures of 22 degrees C and 32 degrees C in seven healthy volunteers. Iodine clearance was reduced at 22 degrees C, and at both temperatures by 16 pcg of adrenaline. Orally administered propranolol (20 mg) enhanced these effects at the lower temperature and that of adrenaline at both temperatures. This method unequivocally demonstrates the aggravation of adrenaline-induced cutaneous vasoconstriction caused by oral administration of propranolol and distinguishes it from that caused by labetalol.

Adult↗

Effects of labetalol and propranolol on responses to adrenaline infusion in healthy volunteers.

The effects of labetalol and propranolol were compared in eight healthy human volunteers using pulse rate and blood pressure changes in response to low rates of adrenaline infusion. Propranolol not only blocked but reversed the positive chronotropic and vasodepressor effects of adrenaline. Labetalol appeared to block these effects only partially. The alpha blocking property of labetalol may have contributed to this difference and hence is unlikely to cause alpha receptor mediated side-effects of endogenously released adrenaline in stress. This model is able to differentiate with great sensitivity between pure beta blockers and alpha beta blocking agents.

Adult↗

Art of teaching.

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Education, Medical↗

Response to single dose of tetanus vaccine in subjects with naturally acquired tetanus antitoxin.

Tests among 410 Indians not artificially immunised against tetanus showed that 80% had measurable antitoxin. Single doses (100 Lf or 250 Lf) of a potent tetanus toxoid were given to such individuals with naturally acquired antitoxin. The 100 Lf dose produced on average a ten-fold rise in antibody level, and the 250 Lf dose a twenty-fold rise. In adults who had been artificially immunised, a 5 Lf dose produced a four-fold to ten-fold rise in antibody level. In infants three doses of triple vaccine produced satisfactory antitoxin concentrations. The levels of antibody achieved after a single 250 Lf dose should protect for 5 years. Single-dose vaccination may be better than the conventional three-dose scheme for a population that is unlikely to comply with a three-dose regimen and in whom naturally acquired antitoxin is associated with partial tolerance to tetanus toxoid. Naturally acquired antitoxin in Indians is probably the result of chronic clostridial contamination of the small bowel. This contamination can induce immune tolerance in the gut and systemically and may be the reason for the poor responses to vaccination in all except infants.

Adult↗