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Biomedical subjects

M P Connor

Publications and source records attributed to M P Connor.

11 recordsLinked to original sources

Developing senior doctors as mentors: a form of continuing professional development. Report Of an initiative to develop a network of senior doctors as mentors: 1994-99.

BACKGROUND: Senior doctors report that mentoring skills are transferable to everyday medical practice and managing juniors. An analysis of views from consultants and general practitioners, who had trained together on a regional mentoring scheme, reveals significant potential for personal and professional development in such networks. CONTEXT: The Northern and Yorkshire Region Doctors' Development and Mentoring Network was set up in 1994. Since then there have been six programmes with 116 senior doctors participating. In 1997 there was an evaluation of the first four programmes. METHOD: Focus groups and postal questionnaire. RESULTS: There were responses from 71 senior doctors, giving a response rate of 86%, and responses from 78 professional stakeholders in 49 NHS organizations, a response rate of 54%. Results indicate that the programmes were highly valued by the participants, particularly with regard to: being part of a network of senior doctors; developing mentoring skills, and engaging in personal and professional development. The most difficult part of the programme was setting up mentoring networks for junior doctors, and reasons included: personal factors, such as levels of confidence in providing mentoring; cultural factors, such as juniors not wishing to be seen to need help, and organizational factors, such as lack of time allocated for mentoring. RECOMMENDATIONS AND ISSUES FOR FURTHER DEBATE: The positive benefits from the scheme raise questions about how to develop mentoring training for senior doctors. Issues include: developing mentors; who needs mentoring; mentoring and the organization; transferability of mentoring skills, and widening the network.

Clinical Competence↗

The requirement for hepatitis A vaccine in Gurkha soldiers.

This Hepatitis A seroprevalence study aimed to determine the cost effectiveness of Hepatitis A vaccination for Gurkha soldiers. One hundred and sixty Gurkha recruits had serum analysed for Hepatitis A IgG. One hundred and fifty nine (99.4%) were IgG positive. Continuing to vaccinate Gurkha soldiers against Hepatitis A will confer little benefit and is not cost effective.

Adolescent↗

Amidines are potent inhibitors of nitric oxide synthases: preferential inhibition of the inducible isoform.

We evaluated the ability of simple alkyl amidines to inhibit the activity of the inducible isoform of nitric oxide (NO) synthase in vitro. In immunostimulated J774 macrophages, 2-iminopiperidine (EC50 = 10 microM) and butyramidine (EC50 = 60 microM) were more potent than NG-methyl-L-arginine (EC50 = 70 microM) in inhibiting nitrite formation. The five amidines tested for their ability to inhibit the conversion of L-arginine to L-citrulline by bovine endothelial cell homogenates (a source of the constitutive, endothelial NO synthase isoform) were less effective than NG-nitro-L-arginine or NG-methyl-L-arginine. The rank-order of the potencies of the amidines against the endothelial NO synthase was, in general, similar to the rank-order of the pressor effects of these agents in anesthetized rats. Thus, certain amidines are potent inhibitors of NO synthase, and are more selective towards the inducible NO synthase than the commonly used L-arginine based NO synthase inhibitors.

Amidines↗

Erysipeloid infection in a sheep farmer with coexisting orf.

Erysipeloid is a rarely reported zoonotic infection caused by Erysipelothrix rhusiopathiae. We report a case of coexisting erysipeloid and orf infections in a sheep farmer, an association not previously recorded to our knowledge.

Administration, Oral↗

Runway malaria in a British serviceman.

'Runway malaria' is a clinical entity first described in 1990 and refers to a patient who has contracted malaria, in whom the only possible exposure has been when the aircraft in which they were travelling has landed transiently in a malarious zone. We describe such a case in a British Serviceman travelling from the South Atlantic to Germany, who acquired malaria in West Africa.

Adult↗

Silicone-grease-based immobilisation method for the preparation of enzyme electrodes.

An approach to the construction of amperometric biosensors based on the incorporation of an enzyme in silicone grease and using the grease to fill micropores on a graphite surface is described. The enzyme-grease electrode concept, illustrated with the enzyme tyrosinase, offers a very simple, rapid and inexpensive approach to the fabrication of enzyme electrodes. The tyrosinase electrode responds very rapidly to dynamic changes in the concentration of phenolic compounds. A response time (t95%) as low as 5 s has been determined. With flow injection, 120 samples per hour can be processed with a relative standard deviation of 2.4%. The electrode remains active for about 12 d. The detection limit for dopamine is 6 x 10(-6) M. This method of biosensor construction should be applicable to other enzyme-substrate systems.

Catechol Oxidase↗

Preinvasive lesions of the endometrium.

Endometrial glandular proliferations form a morphological and biologic continuum. The new definition of stromal invasion provides a means of identifying lesions with a relatively high probability of myometrial invasion and malignant behavior. With more standardized terminology and classification, the natural history of preinvasive lesions is better understood. Caution must be exercised because confusion is hard to avoid completely. It is now apparent that the presence of cytological atypia in a preinvasive lesion identifies a lesion at high risk to develop carcinoma. Glandular hyperplasia without cytological atypia identifies a patient likely to have an abnormal endocrine milieu, but it is not a significant preinvasive lesion and has little tendency to develop into one. The presence of cytological atypia provides the basis for selection of therapy.

Carcinoma↗