Candida infection of the nail: role of Candida as a primary or secondary pathogen.
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Candidiasis↗
Biomedical subjects
M P Daniel
Publications and source records attributed to M P Daniel.
Two feet-one hand syndrome: a retrospective multicenter survey.
BACKGROUND: The two feet-one hand syndrome is not uncommon; however, there have only been a few reports on this condition. This study was undertaken to obtain a better understanding of the epidemiology of the two feet-one hand syndrome. METHODS: A retrospective chart review was conducted of all the patients seen in our practices over the past 15 years with the diagnosis of two feet-one hand syndrome. RESULTS: A total of 80 patients with mycologically confirmed disease were identified (men, 72 (90%); women, 8 (10%); 77 (96%) Caucasian; 3 (4%) African-American; age (mean +/- standard error (SE)), 55.9 +/- 2.1 years). The mean age of the patients when the physician was first seen for the condition was 51.3 +/- 2.0 years. The mean ages when the symptoms first developed on the feet and hand were 37.1 +/- 2.4 years and 45.7 +/- 2.2 years, respectively. Tinea pedis was found to occur at an earlier age than tinea manuum (t(65) = 6.92, P < 0.01). There was a significant relationship between the hand in which tinea manuum developed, the hand used to excoriate the soles of feet (chi 2(4) = 14.82, P < 0.01), and the hand used to pick toenails (chi 2(4) = 14.82, P < 0.01); however, there was no significant relationship between handedness and the development of tinea manuum in the dominant hand. The occupation of the patient at the time of development of the two feet-one hand syndrome was categorized according to whether the intensity of hand use was high, moderate, or low. Patients with a high intensity of hand use in their jobs were significantly more likely to develop tinea pedis/onychomycosis (r = -0.27, F(1,61) = 4.77, P < 0.05) and tinea manuum (r = -0.30, F(1,62) = 6.31, P < 0.05) at an earlier age. The best multiple predictors of the age at which medical attention was sought were the age of onset of tinea manuum and a family history of tinea infection (r = 0.86, F(2,59) = 86.9, P < 0.01). The age of onset of tinea manuum was the best single predictor, with a correlation of 0.85. CONCLUSIONS: In the two feet-one hand syndrome, the development of tinea pedis/onychomycosis generally preceded the development of tinea manuum. Tinea manuum usually developed in the hand used to excoriate the feet or pick toenails. Patients whose occupation involved a high intensity of use of the hands were more likely to develop the disease at an earlier age. Patients were more likely to seek attention once tinea manuum had developed, particularly if there was a family history of tinea infection.
Adolescent↗
Chronic paronychia and onycholysis: a thirteen-year experience.
We report here on two retrospective studies conducted between 1982 and 1995 in 137 patients with clinical evidence of chronic paronychia or onycholysis. The purpose of the studies was to determine what factors played a role in these nail disorders. The culture results indicated that yeast commonly grew from the cultured material. Significant contact irritant exposure was frequently found. These findings and our experience suggest that the resolution of chronic paronychia and onycholysis depends on avoiding exposure to contact irritants and on appropriate treatment of any underlying fungal infection. To accomplish this latter goal, it is important to select a broad-spectrum antifungal agent that is effective against yeasts as well as other fungal pathogens.
Adolescent↗
Onychomycosis update.
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AIDS-Related Opportunistic Infections↗
Renal function immediately after piezoelectric extracorporeal lithotripsy.
We evaluated changes in renal function in 14 patients treated for renal calculi with the Richard Wolf 2300 piezoelectric lithotriptor. Each patient received, 3,000 to 4,000 shocks at the maximal recommended voltage. Each patient was evaluated with 131iodine-orthoiodohippurate renal scans performed within 24 hours before and after treatment. Changes in total effective renal plasma flow, effective renal plasma flow of the treated kidney and differential renal function were compared by paired t testing. No significant changes were associated with lithotripsy. On the basis of the renal scans we conclude that piezoelectric lithotripsy causes no significant changes in renal function, even in the early post-treatment period based on renal scan studies.
Humans↗