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Biomedical subjects

M P Goldman

Publications and source records attributed to M P Goldman.

At least 19 recordsLinked to original sources

Intravascular lasers in the treatment of varicose veins.

Historically, surgical treatments, such as high ligation or complete removal of an incompetent greater saphenous vein, were used to treat varicose veins resulting from saphenofemoral junction reflux. The relative lack of efficacy of these invasive methods, along with potential morbidity and significant patient downtime, has inspired the search for other treatments. Endovenous radiofrequency closure of the greater saphenous vein is effective and safe but its high cost, in terms of non-reusable catheters, and its slow withdrawal rate impair its practicality. A new technique for endovenous occlusion using endoluminal laser technology offers a less invasive alternative to ligation and stripping as well as a faster and less expensive method to treat varicose saphenous trunks and junctions. Initial clinical experience in several hundred patients shows a high degree of success with minimal side effects, most of which can be prevented or minimized by minor modifications of the technique. This paper reviews the use of an intravascular laser to destroy varicose veins. Various wavelengths including 810, 940, 980, 1064 and 1320 nm have been used to produce intravascular destruction of varicose veins. The 1320-nm intravascular laser with a motorized pull-back system appears to be the most efficient and reproducible system to effectively close and/or destroy an incompetent greater saphenous vein.

Journal Article↗

Implementation and pharmacoeconomic analysis of a clinical staff pharmacist practice model.

The implementation and pharmacoeconomic analysis of a clinical staff pharmacist (CSP) practice model are described. Staff pharmacists at a large, tertiary care, academic medical center were selected and trained to perform clinical pharmacy services under the direction of clinical pharmacy specialist mentors. Clinical interventions by these CSP practitioners were evaluated in terms of direct cost savings (the difference in actual acquisition costs between therapies) and cost avoidance (the dollar value of adverse drug events [ADEs] avoided). The CSPs performed a total of 4959 interventions during a 12-month period. The interventions provided direct cost savings of $92,076 and an estimated cost avoidance of $488,436. Comparing cost savings and cost avoidance with the expenses of providing these services indicated a net economic benefit of $392,660. A new model of pharmacy practice that integrates staff pharmacists into existing clinical practice has the potential to minimize the risks, decrease the costs, and improve the outcomes associated with drug therapy.

Cost Savings↗

Resurfacing of photodamaged skin on the neck with an UltraPulse((R)) carbon dioxide laser.

BACKGROUND AND OBJECTIVE: Successful treatment of facial wrinkles with carbon dioxide or erbium laser resurfacing brings about a more youthful appearance of the skin on the face. A variable degree of contrast with the untreated skin on the neck prompts many patients to request treatment for photodamaged skin on the neck. The objective is to investigate the feasibility of resurfacing photodamaged skin on the neck with the UltraPulse((R)) carbon dioxide laser. SUDY DESIGN/MATERIALS AND METHODS: The study was carried out in two phases. During the first phase, a small area on the upper neck was tested with three different parameters. The best parameter was then used to treat the neck area in a single pass in 10 cases in the second phase. Patients were then evaluated at 3-6 months. RESULTS: The three parameters tested were 200 mJ at CPG settings of pattern 3, size 9, density 6, 300 mJ at CPG 3-9-5, and 300 mJ at CPG 3-9-6. The latter seemed to achieve the best results, and there were no complications at any test sites. This setting was used to treat the whole anterior and anterolateral part of the neck with a single pass, wiping away the resultant epidermal debris. Moderate improvement in color and texture, but no improvement in wrinkling, were observed at 3-6 months. However, a mild degree of patchy hypopigmented scarring in the lower neck was encountered in three cases, as well as one other case of patchy hypopigmentation without textural changes. CONCLUSIONS: Despite some obvious improvements, the risk of scarring and hypopigmentation with the tested parameters out-weighs the potential benefits. The lower part of the neck responded very differently from the upper part. Alternative strategies to achieve better results are discussed.

Aged↗

Laser resurfacing with a long pulse erbium:YAG laser compared to the 950 ms pulsed CO(2) laser.

BACKGROUND AND OBJECTIVE: Laser resurfacing with the 950 micros pulsed CO(2) laser is an effective treatment for photodamage and acne scarring; however, the potential for prolonged erythema and delayed re-epithelialization dissuade many patients from the procedure. With the use of erbium lasers alone, there is a decrease in the incidence and severity of these adverse sequelae; however, it is difficult to achieve the same degree of improvement as with the CO(2) laser because of the more superficial depth of resurfacing. Thus, new erbium lasers have been developed with longer pulse durations to deliver increased thermal effects to tissue. It is hypothesized that with the use of these lasers, diminished erythema and faster wound healing will be observed as well as enhanced clinical outcomes. STUDY DESIGN/MATERIALS AND METHODS: Sixteen patients were randomized to receive laser resurfacing on one-half of the face with the 950 micros pulsed CO(2) laser (UPCO(2)) followed by short pulse erbium:YAG ablation, and to the other half with a variable pulsed erbium laser (VP Er:YAG) followed by traditional short pulse erbium laser. Patients were evaluated clinically before resurfacing and at 1, 2, 4, 8, and 12 weeks post-operatively. Histologic samples taken at various time periods before and after resurfacing were also evaluated. RESULTS: Overall clinical improvement was equal for both UPCO(2) and VP Er:YAG treated sides with an average improvement in photoaging scores of 57%. Decreased erythema, less edema, and faster healing were observed on the VP Er:YAG treated side. CONCLUSION: The VP Er:YAG laser can achieve a similar degree of improvement as seen with short pulse CO(2) laser resurfacing with decreased thermal tissue effects and decreased risk for adverse sequelae.

Face↗

Interpenetrating polymer network wound dressing versus petrolatum following facial CO2 laser resurfacing: a bilateral comparison.

BACKGROUND: Occlusive dressings increase the speed of epidermal wound healing by decreasing wound adherence, maintaining a moisture barrier, and allowing contact with healing factors. OBJECTIVE: To test whether a thin film of silicone and polytetrafluoroethylene blended into an interpenetrating polymer network (SPIPN) can provide improved healing over petrolatum following CO2 laser resurfacing injury. METHODS: A bilateral comparison of closed SPIPN versus open healing following two different CO2 laser delivery systems for resurfacing was performed. Twenty patients were followed and evaluated at days 1, 2, 3, 7, 14, 30, 60, and 90 for exudate, erythema, rate of epithelialization, pigment changes, postoperative pain, pruritus, cosmetic results, preference, and duration of postoperative complications. RESULTS: Results demonstrated improved healing for SPIPN compared to petrolatum alone. Markedly decreased exudate was seen in 90% of the SPIPN dressing sides. Erythema during the first 72 hours was 1.95 for SPIPN versus 2.6 for open (scale 1-4) (P <.05). Pruritus was 1.67 versus 2.44 (P <.05) for SPIPN versus open during the first 3 days postoperatively. Approximately 75% of the patients preferred SPIPN to control petrolatum. The rate of reepithelialization was also better for the SPIPN dressing, taking only 2 days versus 2.8 days for open control. Approximately 50% of the patients reported decreased pain on the SPIPN side at days 1 and 2. CONCLUSIONS: SPIPN dressing provides an easily applied, easily tolerated dressing for use after laser resurfacing. Many patients benefit from faster healing, reduced exudate, better appearance during the postoperative period, and decreased postoperative discomfort.

Bandages↗

Energy density and numbers of treatment affect response of keloidal and hypertrophic sternotomy scars to the 585-nm flashlamp-pumped pulsed-dye laser.

BACKGROUND: The 585-nm flashlamp-pumped pulsed-dye laser (PDL) has proven to be the treatment of choice for certain keloids and hypertrophic scars, but the precise fluence, numbers of treatment, and treatment interval remain anecdotal. OBJECTIVE: This study was performed to determine whether the therapeutic outcome of the PDL varies with the energy density (fluence) of the laser pulses and numbers of treatment. METHOD: Ten previously untreated, erythematous, keloidal or hypertrophic median sternotomy scars of 10 patients were divided into 4 segments and were randomly treated with a 585-nm PDL at a fluence of 3, 5, and 7 J/cm(2) to 3 of 4 segments every 4 weeks for a total of 6 treatment sessions. One segment of each patient's scars was untreated and served as a control. Clinical improvement including scar height, erythema, and pliability was evaluated before treatment and every 8 weeks for a total period of 32 weeks. Self-assessment was also determined by patients on a 25% increment of improvement scale comparing week 0 and week 32. RESULTS: A significant improvement in scar height, erythema, and pliability was noted in all laser-treated scar areas. There was no significant difference in treatment outcome versus the fluence of the laser (3, 5, and 7 J/cm(2)), although there was a trend for lower fluences to show more improvement. Objective clinical improvement was seen as early as week 16, after more than two treatments were given. Multiple treatments (>2) appeared to provide a greater percentage of scar resolution. CONCLUSIONS: The clinical improvement of scars after PDL treatment demonstrates no statistically significant fluence dependence in this study, but a trend toward better response with lower fluences is seen. In addition, multiple treatment sessions are suggested for achieving greater response.

Adult↗

Treatment of poikiloderma of Civatte on the neck with an intense pulsed light source.

Effective treatment of poikiloderma of Civatte is difficult. The ideal treatment combines elimination of both the vascular and pigmented components simultaneously. Treatment with a broad-spectrum noncoherent intense pulsed light source delivers multiple wavelengths with software-controlled pulse durations and sequencing that permit treatment of both vascular and pigmented lesions simultaneously. The objective of this study was to determine the response and side effects of treating this condition with intense pulsed light. In the study, 66 patients with typical changes of poikiloderma of Civatte on the neck were treated with intense pulsed light at various settings every 4 weeks until the desired improvement occurred. A 50 to 75 percent improvement in the extent of telangiectasias and hyperpigmentation was observed after an average of 2.8 treatments. The incidence of hypopigmentation was 5 percent. It was concluded that intense pulsed light is an effective mode of therapy for poikiloderma of Civatte. It seems to offer a reduction in both pigmentation and telangiectasia-associated erythema, with minimal side effects.

Adult↗

CO2 laser resurfacing of the face and neck.

Laser resurfacing with the short-pulsed, high-energy CO2 laser has been used to treat photodamaged skin and acne scars. Efficacy and safety have been demonstrated with this technique since 1992. Newer treatment methods, including sequential or combination treatment with the Er:YAG laser have led to increased efficacy with a decrease in adverse sequelae. This article details the author's experience with CO2 laser resurfacing and promotes the use of sequential CO2/Er:YAG laser resurfacing.

Carbon Dioxide↗

Extensive tissue necrosis following high-concentration sclerotherapy for varicose veins.

BACKGROUND: Tissue necrosis after sclerotherapy has been observed, but is unexplained. OBJECTIVE: To present the complication of extensive tissue necrosis following high-concentration sclerotherapy for varicose veins. METHODS: Cases coming to the attention of the authors are presented briefly with commentary and discussion to explain the mechanisms of tissue destruction. RESULTS: Although the complication of extensive tissue necrosis has been ascribed to intra-arterial injection, in fact, careful study of the cases described here shows that intravenous injection was present in each case. A theory of distribution of the sclerosant into the arterial arborization is proposed. This theory would explain the distribution of sclerosant into the arterial tree and would also explain the causation of extensive tissue necrosis. Mention is made of experimental work in which intra-arterial injection was not the mechanism of causation of tissue necrosis. CONCLUSION: Extensive tissue necrosis following high-concentration sclerotherapy may be rare, but its occurrence is serious and its treatment may be incomplete.

Adult↗

Treatment of poikiloderma of Civatte with an intense pulsed light source.

BACKGROUND: Effective treatment of poikiloderma of Civatte combines elimination of both the vascular and pigmented components simultaneously. A broad spectrum, noncoherent, intense pulsed light (IPL) source delivers multiple wavelengths with software controlled pulse durations and sequencing, which permits treatment of both vascular and pigmented lesions simultaneously. OBJECTIVE: To determine response and side effects of poikiloderma of Civatte of the neck and chest when treated by IPL. METHODS: One hundred and thirty-five patients randomly selected with typical changes of poikiloderma of Civatte on the neck and/or upper chest were treated with one to five treatments using IPL. RESULTS: Clearance of more than 75% of telangiectasias and hyperpigmentation comprising poikiloderma was observed. The incidence of side effects was 5%, including pigment changes. In many cases, improved skin texture was noted both by physician and patient. CONCLUSION: IPL is an effective mode of therapy for poikiloderma of Civatte. It offers a reduction of pigment and telangiectasias with a low risk profile. Additional benefits include subjective changes of improvement in skin texture.

Adult↗

Treatment of facial skin using combinations of CO2, Q-switched alexandrite, flashlamp-pumped pulsed dye, and Er:YAG lasers in the same treatment session.

BACKGROUND: Many patients who seek facial CO2 laser resurfacing for improvement of photodamage are also concerned with "dark circles" under their eyes (periorbital hyperpigmentation) and/or telangiectasia as well as various types of deep scars on their faces. CO2 laser resurfacing alone provides limited improvement for these problems. OBJECTIVE: The purpose of this study was to demonstrate the conjunctive therapeutic effects of the CO2, Q-switched alexandrite, Er:YAG, and/or flashlamp-pumped pulsed dye lasers on facial skin treatments. METHOD: Thirty patients who underwent CO2 laser resurfacing were treated with additional lasers specific for their cosmetic concerns. Twenty patients with facial telangiectasias were treated with the pulsed dye laser immediately prior to CO2 laser resurfacing. Eleven patients with periorbital hyperpigmentation were treated with the Q-switched alexandrite laser immediately following use of the pulsed CO2 laser. Eight patients having sharply defined acne scars were treated with the Er:YAG laser following use of the CO2 laser. All patients had peripheral feathering performed with the Er:YAG laser. Nine patients were treated with all four lasers. RESULTS: In addition to significant improvement of the wrinkle scores from the CO2 laser resurfacing, patients had 75-100% clearing of the periorbital hyperpigmentation. All patients with facial telangiectasia showed virtually 100% improvement. All deep wrinkles and sharply defined scars responded with combined CO2/Er:YAG laser better than with CO2 laser resurfacing alone. All feathering was more uniform, with a more subtle transition to nontreated skin. There were no complications that could be attributed to the simultaneous use of multiple lasers. CONCLUSIONS: For patients who present with multiple cosmetic complaints, combined treatment using appropriate lasers offers excellent therapeutic outcome.

Acne Vulgaris↗

Laser skin resurfacing of the face with a combined CO2/Er:YAG laser.

BACKGROUND: A combined, dual-wavelength CO2/Er:YAG laser system having the ability to deliver both clean ablation of skin with the erbium wavelength and a simultaneous deeper penetrating subablative thermal pulse of CO2 was developed for full-face resurfacing. The CO2 component can be pulsed from 1 to 100 msec at a power of 1-10 W with the Er:YAG component pulsed at 350 microsec at 1.7 J/cm2 through either a computer pattern generator with 3 mm diameter spot size or through a noncollimated spot ranging from 0.2 to 8 mm in diameter. Our previous study using this laser on the neck using a 4-8 mm diameter spot with Er:YAG fluence at 1.7 J and the CO2 at 5 W with a 50 msec pulse at a frequency of 10 Hz showed a higher degree of overall patient satisfaction, as well as improvement in skin texture and skin color, compared to patients treated with an Er:YAG laser alone. OBJECTIVE: This study evaluated the CO2/Er:YAG laser treatment modality in facial resurfacing. METHODS: Ten patients were treated with four passes at 1.7 J with a 4 mm diameter spot and the CO2 at 5 W with a 50-msec pulse at a frequency of 10 Hz. Photoaging scores as well as thermal damage and new collagen formation were compared immediately before and after treatment as well as at 2 weeks and 3 months postoperatively. RESULTS: The average pretreatment periorbital score was 6.2 The average posttreatment periorbital scores were 4.2 (P =.0239) at 2 weeks postoperatively (32% improvement) and 3.8 (P =.0028) at 3 months postoperatively (38% improvement). The average pretreatment perioral score was 5.9. The average posttreatment perioral scores were 3.0 (P =.0001) at 2 weeks postoperatively (49% improvement) and 3.3 (P =.0009) at 3 months postoperatively (44% improvement). The average pretreatment cheek score was 4.7. The average posttreatment cheek scores were 2.7 (P =.0066) at 2 weeks postoperatively (43% improvement) and 3.8 (P =. 0152) at 3 months postoperatively (36% improvement). The average pretreatment forehead score was 4.7. The average posttreatment forehead scores were 3.8 (P =.0340) at 2 weeks postoperatively (33% improvement) and 3.6 (P =.0147) at 3 months postoperatively (37% improvement). The average depth of collagen measured in the dermis pretreatment was 29 microm. The average depth of collagen 3 months posttreatment was 54 microm. This is an average increase of 25 microm or an 86% increase in collagen (P =.006). The average thermal damage immediately after treatment was 20 microm. CONCLUSION: The CO2/Er:YAG laser utilized with four passes at the above-mentioned parameters results in a similar degree of improvement as other forms of laser resurfacing with high-energy, short-pulsed CO2 lasers.

Adolescent↗

Effect of external ultrasound postliposuction: a side-to-side comparison study.

BACKGROUND: External ultrasound (EUS) has been used as a therapeutic modality for more than 30 years by multiple medical specialists, primarily for stimulating the repair of soft tissue injuries and relieving pain. It has also been used to treat postoperative swelling after liposuction. There are no controlled studies documenting the objective and subjective effects of EUS following liposuction. OBJECTIVE: The purpose of this preliminary study was to evaluate the role of EUS in the relief of postoperative symptoms following traditional tumescent liposuction. METHODS: Twenty-five patients underwent tumescent liposuction of the abdomen or hips. Within 2 weeks after the procedure, a double-blind study was initiated in which EUS therapy was applied at therapeutic energies to one-half of the treated area, while the other side was treated with placebo settings. Patients were treated biweekly for a total of six to eight treatments. Both objective and subjective parameters were assessed during the subsequent side-by-side evaluations by the patient and observer. RESULTS: After four treatments, 18 of 25 patients had the same postoperative symptoms on each side. Two had fewer symptoms on the EUS side and five were worse on the EUS side. After completion of all treatments, 17 of 25 again had the same symptoms on the therapeutic and placebo sides. Three had improved symptoms and five were worse on the EUS side. The subjective findings revealed that all patients believed the treatment helped significantly on both the placebo and EUS-treated sides. CONCLUSION: EUS after liposuction of the abdomen at the study parameters provided no objective benefit compared to placebo in postoperative recovery. Patient acceptance and perception of benefit are high. Further studies are needed to determine the optimal timing and energies required for therapeutic value.

Abdomen↗

Q-switched ruby laser treatment for postsclerotherapy hyperpigmentation.

BACKGROUND: One of the most common adverse sequelae of sclerotherapy is cutaneous hyperpigmentation. OBJECTIVE: We used the Q-switched ruby laser to treat postsclerotherapy hyperpigmentation. METHODS: Eight patients developed pigmentation lasting more than 1 year (1-2 years on average) after sclerotherapy treatment for reticular and telangiectatic veins in the legs ranging in size from 0.2 to 4 mm in diameter. All patients were treated with a Q-switched ruby laser at 694 nm, 4 mm beam size, and fluence range of 5.6-10.5 J/cm2. RESULTS: Ninety-two percent of lesions lightened after treatment. There was significant (75-100%) resolution of hyperpigmentation in 58% of treated areas, 25% improvement in 33% of treated areas, and no improvement in the remaining areas. CONCLUSION: Our impression is that given a choice of lasers, the Q-switched ruby laser provides the greatest efficacy for treating postsclerotherapy hyperpigmentation.

Humans↗