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Biomedical subjects

M P Gorizontova

Publications and source records attributed to M P Gorizontova.

At least 19 recordsLinked to original sources
PubMed1993

[Microcirculatory changes during the long-term course of deafferentation pain syndrome].

It was shown that during 5 months after section of the sciatic nerve in 100% of rats the extremity's autotomies took place. In clinic development of deafferentation pain syndrome the waves character of autotomy was previal (86%); the maximal waves during 6 month was 6. In 14% of animals it was shown the deafferentation pain syndrome with permanent autotomy. The disorders of terminal blood flow, increase venular permeability and mast cells degranulation was shown in rats with hard autotomy. The microcirculation disturbances increased in case of autotomy repeated. The recovery of extremities with autotomy correlated with normalization of microcirculation. The microcirculation disorders (stasis) and degranulation of the mast cells were hard in rats with permanent autotomy then in rats with repeated autotomy.

Afferent Pathways↗
PubMed1993

[The formation of a pathological system in rats with neuropathic trigeminal neuralgia].

The intensity of clinical manifestations (rubbing of the oro-facial area with skin injury), bioelectric activity of the somatosensory cortex and microcirculatory disturbances were studied for 6 weeks in Wistar rats with partial infraorbital nerve compression. These parameters were compared among rats of the following groups: without skin rubbing (1), with them (2), with repaired skin (3) after nerve compression and sham-operated rats (4). A correlation between the intensity of clinical manifestations and microcirculatory disturbances was shown. Epileptiform cortex activity was observed in 100% and 75% rats of the 2nd and 3rd groups, respectively, while in group 1 this per cent decreased time. These results are discussed with regard to the formation of pathologic algic system which underlies the pain syndrome and affects peripheral target organs.

Animals↗
PubMed1992

[Effects of verapamil on the development of pain syndrome in rats after section of the sciatic nerve].

The effect of daily verapamil administration (5 mg/kg) on pain sensitivity, bioelectric activity of cerebral cortex and microcirculation was studied in rats with cut sciatic nerve. Verapamil untreated rats showed hyperalgesia, autotomies and hypersynchronic discharges in contralateral hemisphere, increased range of evoked potentials and disorders in microcirculatory system which evidence developing pain syndrome. Early introduction of verapamil after the nerve cut prevented the emergence of pain syndrome.

Animals↗
PubMed1991

[The microcirculatory system in hamsters in a model of central pain syndromes].

Experimental models of central pain syndromes, namely, trigeminal neuralgia (TN) and a pain syndrome of spinal origin, were developed in Syrian hamsters. Microhemocirculatory disorders, increased venular permeability, and increased mast cell degranulation in the mucosa of the cheek pouches were revealed. The importance of studying microcirculation in the cheek pouches of hamsters, especially in experimental TN is discussed, because appraisal of microcirculation in both pouches allows the beginning of generalization disorders to be determined.

Animals↗
PubMed1991

[Pain syndrome in rats after injury to the sciatic nerve].

Chronic experiments were conducted on rats to study the peculiarities of changes of pain sense and the components of the microcirculatory system after division of the sciatic nerve. It was established that division of the sciatic nerve leads in 1-2 weeks to the development of hyperalgesia, the appearance of autotomies, disorders of the microcirculatory system, which are evidence of the development of the pain syndrome.

Animals↗
PubMed1991

[Microcirculatory changes in experimental trigeminal neuralgia in rats].

Biomicroscopic studies of mesentery in trigeminal neuralgia rats caused by creation of a generator of pathologically enhanced excitation in trigeminal nerve caudal nucleus (injection 0.25-1.0 DLM Tetanus toxin) have shown the microcirculatory disorders, venular permeability, mast cells degranulation, and an increase in lymphatic contractile activity. Microcirculatory disorders intensity and adaptation reaction appearance correlated with trigeminal neuralgia clinical picture.

Animals↗
PubMed1990

[Effects of SP1-11 and its N-terminal fragment SP1-4 on several indices of the microcirculatory system in stress].

In the experiments on rats it was shown that 5-hour immobilization induced the disturbances of terminal blood flow, degranulation of mast cells, increase of venular permeability and contractile activity of lymphaticus. I/p injection SP1-11 (125 micrograms/kg) before stress aggravated the disturbances caused by immobilization. The prophylactic i/p injection SP1-4 induced tranquilizing (100%), sedative (30%) or narcosis (20%) effect. In the rats with sedative or narcosis effects the relative normalization of components of microcirculatory system was observed.

Animals↗
PubMed1990

[Effects of verapamil on behavioral and microcirculatory disorders in pain syndrome of spinal etiology].

In the experiments on Wistar rats with pain syndrome of spinal origin (PSSO) caused by the generator of pathologically enhanced excitation (GPEE) in dorsal horns of the spinal cord lumbosacral segments, it was shown that the intravenous verapamil injection (1.25 mg/kg) undoubtedly decreased behaviour response and improves the state of microcirculation. The compound of 10-fold decreased dose does not affect the behaviour response and microcirculation. When PSSO exists, the intravenous injection of analgin (150 mg/kg) produced an effect on the behaviour response and does not produce any action on microcirculation. When verapamil reaches the dorsal surface of the spinal cord (GPEE area) it decreases the behaviour response and microcirculation disorders created in PSSO. The obtained data make it clear that the GPEE depression caused by the verapamil calcium channel blocker weakens PSSO and normalizes the microcirculation.

Animals↗
PubMed1989

[Effect of substance P and its N-terminal fragment on the components of the normal microcirculatory system and under stress].

The biomicroscopy experiments showed that the substance P N-terminal fragment (SP1-4) is not as injurious as the SP1-11 for the rat mesentery. The SP1-4/SP1-11 activity ratio is 0.007 to 1 in case of microcirculation disturbances and venular permeability increase, and 0.0007 to 1 in case of the mast cells degranulation increase. Injection of SP1-11 (125 micrograms/kg) prior to the 5-hr immobilization, enhanced the disturbances in microcirculatory system induced by the stress. Injection of SP1-4 (53 micrograms/kg) led to sedative or narcotic effects in 50% of rats correlated with the normalizing terminal blood flow, venular permeability and mast cells secretory activity.

Animals↗
PubMed1989

[Globulin transport in the microcirculatory system under normal and stress conditions].

Biomicroscopic studies of rat mesentery during 24-hours immobilization have shown phasic changes in globulin-FITC transport in the system: venule-interstitial-lymphatic microvessel. During short immobilization we have discovered the increasing contraction of lymphatic microvessels; during long immobilization--the decreasing contraction has been discovered.

Animals↗
PubMed1988

[Effect of the N-terminal fragment of substance P on the microcirculatory system].

Biomicroscopic experiments have shown that the N-terminal fragment of substance P (SP1-4), when applied to the rat mesentery, has a considerably lower injuring effect than substance P (SP1-11) itself. SP1-4 activity, as compared to SP1-11 activity regarded as 1, was 0.007 in case of microcirculatory disturbances and venular permeability increase and 0.0007 in case of mast cell degranulation increase. The data obtained suggest that the slightest damaging effect of SP1-4 on microcirculation is combined with anti-stress activity.

Animals↗