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M P Hiorns

Publications and source records attributed to M P Hiorns.

10 recordsLinked to original sources
PubMed2006

A review of current local dose-area product levels for paediatric fluoroscopy in a tertiary referral centre compared with national standards. Why are they so different?

A prospective single centre study has been performed to assess dose-area product (DAP) values in children having fluoroscopic examinations and to revise local diagnostic reference levels (DRLs). DAP measurements for 2658 examinations performed in a dedicated fluoroscopy room over a period of 21 months were analysed. Data for the eight most commonly performed examinations (2215 cases) are presented. DAPs (75th centile) for upper gastrointestinal studies and micturating cystograms are substantially lower (by a factor of between x 5 and x 25) than the current national reference doses (NRDs), with some of the median values being 50 times lower. The small DAP values in all examinations demonstrate the substantial reduction in dose and consequent risk that can be achieved when both equipment performance and operator technique are optimized. Whilst we recognize that different institutions will have differing practices, it is important that practitioners are aware of the range of DAPs achievable and that NRDs do not necessarily represent best practice, and may falsely reassure.

Adolescent↗
PubMed2005

Serial high resolution CT in non-specific interstitial pneumonia: prognostic value of the initial pattern.

AIM: To assess the relationship between initial CT pattern and serial changes in CT findings and pulmonary function tests (PFTs) in patients with non-specific interstitial pneumonia (NSIP). MATERIALS AND METHODS: Serial high resolution (HR) CTs and PFTs were retrospectively analyzed in 38 cases of histologically proven NSIP, including 4 with cellular NSIP, 13 with mixed cellular and fibrotic NSIP, and 21 with fibrotic NSIP. The presence and extent of various CT findings were assessed. A fibrosis index (defined as the ratio of the extent of a reticular/honeycomb pattern to the overall extent of abnormal parenchyma) was derived. RESULTS: The predominant CT pattern was reticular/honeycomb in 27 (84%) cases and ground-glass/consolidation in 6 (16%) cases. Between scans, mean disease extent reduced by 5.2%. Disease extent reduced by >10% in 13 (34%) and increased by >10% in 6 (16%) patients. Histopathological subtype of NSIP did not correlate with individual CT pattern, predominant pattern, fibrosis index or serial change in disease extent on CT or PFTs. Response on follow-up CT was associated with fibrosis index, predominant pattern and extent of consolidation on initial CT. CONCLUSION: In NSIP disease, progression on CT correlates with the predominant CT pattern, fibrosis index, and extent of consolidation but not with histopathological subtype. An inflammatory (ground-glass/consolidation) predominant pattern is associated with better outcome in terms of disease extent on HRCT.

Disease Progression↗
PubMed2003

Dysphagia caused by a foreign body.

A boy with a long history of dysphagia attributed to neurological impairment was shown to have a large oesophageal foreign body. It had remained undetected for five years as a central lumen allowed the passage of liquids and semisolids. Foreign bodies must be excluded in children with dysphagia.

Child↗
PubMed2003

Hadju-Cheney syndrome: response to therapy with bisphosphonates in two patients.

Hadju-Cheney syndrome is characterized by short stature, distinctive facies, and a slowly progressive skeletal dysplasia including acro-osteolysis. Autosomal dominant inheritance is typical, but the genetic defect and molecular pathogenesis of the syndrome are unknown. Osteoporosis with atraumatic fracture is a frequent finding, and previous studies have documented biochemical and morphometric evidence of high bone turnover. Here, we report the clinical details and response to therapy with bisphosphonates in two patients (mother and son) with Hadju-Cheney syndrome and postulate that osteoclast-mediated bone resorption is important in the generalized osteoporosis commonly associated with this condition.

Acro-Osteolysis↗
PubMed2001

Radiology of neuroblastoma in children.

The radiology of neuroblastoma reflects the diversity of the manifestations of this condition. The current radiological practice for imaging is outlined and illustrated with emphasis on cross-sectional and radionuclide imaging.

Child↗
PubMed2001

Acute lung disease in the immunocompromised host.

The immunocompromised host is an individual with a decreased defense mechanism or immunity. Pulmonary complications commonly seen in these patients include infections, neoplasms, drug-induced lung disease, and pulmonary hemorrhage. High-resolution CT plays an invaluable role in confirming the presence of pulmonary disease and narrowing down the differential diagnosis in this group of patients. It also is helpful as a guide to the optimal type and site of biopsy. The pattern and prevalence of disease varies considerably between the AIDS and the non-AIDS group, and therefore, these two groups are considered separately.

Acquired Immunodeficiency Syndrome↗