Biomedical subjects
Publications and source records attributed to M P James.
Four patients with inflammatory bowel disease and severe cystic acne were treated with isotretinoin. Two patients had a successful course of treatment without any gastrointestinal side-effects. One patient had two episodes of profuse rectal bleeding that were probably related to pre-existing haemorrhoids. The fourth patient had a flare-up of his Crohn's disease after starting isotretinoin.
The case is reported of a child who presented with brownish macules and papules on the face and in whom biopsies confirmed a diagnosis of benign cephalic histiocytosis. The clinical and histological features of our case are typical for this rare self-healing non-Langerhans cell histiocytic disorder.
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The clinical and histological features of ten pigmented keratoses arising on the face are described. They were all greater than 1.5 cm in diameter and had been spreading centrifugally. They were variably pigmented and possessed either a smooth, verrucous or slightly scaly surface. Two lesions had progressed to become pigmented squamous cell carcinomas.
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A modified radiographic technique was used to assess dermal atrophy induced by topical steriods. The method proved reliable, and significant atrophy occurred with fluocinolone acetonide, clobetasone butyrate, hydrocortisone 17-butyrate and flurandrenolone, but not with hydrocortisone.
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Explore the source record for details and available documents.