PubMed Health⌕ Search

Biomedical subjects

M P Klaassen

Publications and source records attributed to M P Klaassen.

2 recordsLinked to original sources

Follow-up after colorectal cancer: current practice in The Netherlands.

OBJECTIVE: To assess the current practice of follow-up after operations for colorectal cancer in The Netherlands in comparison with other countries. DESIGN: Postal survey. SETTING: All surgical departments in The Netherlands. MAIN OUTCOME MEASURES: Attitudes of surgeons towards detection and treatment of recurrences after colorectal cancer. RESULTS: Of the 139 questionnaires sent out, 136 (98%) were returned. History taking, physical examination, and colonoscopy for local recurrence and metachronous tumours were used by 90% of the hospitals. Attitudes towards screening for hepatic and pulmonary metastases and regional recurrence varied considerably between hospitals. Similar findings were found in seven surveys from other countries. CONCLUSION: There is no consensus among surgeons regarding the follow-up of patients with colorectal cancer. Randomised controlled trials comparing different follow-up strategies and cost-effectiveness analyses are needed to identify groups of patients that will benefit most from follow-up. Identification of these patients may lead to more agreement between surgeons.

Colorectal Neoplasms↗

Confidence intervals for cost/effectiveness ratios.

The reduction of costs is becoming increasingly important in the medical field. The relevant topic of many clinical trials is not effectiveness per se, but rather cost-effectiveness ratios. Surprisingly, no statistical tools for analyzing cost-effectiveness ratios have been provided in the medical literature yet. This paper explains the gap in the literature, and provides a first technique for obtaining confidence intervals for cost-effectiveness ratios. The technique does not use sophisticated tools to achieve maximal optimality, but seeks for tractability and ease of application while still satisfying all formal statistical requirements.

Clinical Trials as Topic↗