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Biomedical subjects

M P Kumarasinghe

Publications and source records attributed to M P Kumarasinghe.

10 recordsLinked to original sources
PubMed1997

First reports of subcutaneous sparganosis in Sri Lanka.

OBJECTIVE: To report and create awareness of sparganosis, a parasitic zoonosis caused by a larval stage of Spirometra sp. SETTING: Two patients with non-tender subcutaneous lumps. DIAGNOSIS CRITERIA: Morphology of solid cestode larva in excision biopsies. CONCLUSIONS: Although these two instances were innocuous, infection is potentially dangerous as larvae are long lived and could invade vital organs. The most likely source of infection in Sri Lanka is ingestion of the infected first intermediate host, Cyclops, in water.

Adult↗
PubMed1995

Fine needle sampling without aspiration.

Four hundred and ten thyroid nodules, 127 breast lumps and 43 lymph nodes were sampled and analyzed to compare the classical aspiration (ASP) technique with the non aspiration needle jab (NASP) technique. The adequacy of cellularity, significant blood staining and the discomfort felt by the patient were assessed and statistically analyzed. The non aspiration technique was found to be superior to the classical aspiration technique for fine needle sampling of thyroid in all aspects. However, for breast lesions, while the discomfort felt and the staining with blood was less with the non aspiration technique, the overall cellular yield was unsatisfactory. The adequacy of cellular yield was, however, comparable for malignant breast lesions with either technique. For lymph node sampling, both techniques showed equivalent results with regard to the cellularity but, the NASP technique was superior in other aspects. Although the overall patient discomfort and blood staining was significantly less, the adequacy of the cellularity was influenced by the site and the nature of the lesion. Thus it can be concluded that the technique needs to be selected depending on the anatomic site, the clinical situation, the personal experience and the preference of the operator.

Biopsy, Needle↗
PubMed1994

Necrotising lymphadenitis of Kikuchi and Fijimoto in Sri Lanka.

We present the clinicopathological features of 10 patients with Kikuchi's lymphadenitis. It is important to distinguish this unusual form of necrotising lymphadenitis, both clinically and histologically, from lymphoma and infective lymphadenitis, including mycobacterial infection. The 10 lymph node biopsies studied were from young adults (9 women) with fever, cervical lymphadenopathy and elevated ESR. This is the first documentation of this condition in Sri Lanka. This benign self-limiting condition can be mistaken for lymphoma or infective lymphadenitis.

Adolescent↗
PubMed1993

Atypical presentations of pulmonary tuberculosis diagnosed by fibreoptic bronchoscopy.

A total of 356 patients were subjected to fibreoptic bronchoscopy from September 1989 to June 1991 to exclude bronchial carcinoma. Bronchial biopsy, bronchial brush smears and bronchial wash were obtained. Bronchial wash was examined for acid fast bacilli (AFB) compatible with Mycobacterium tuberculosis. The total number diagnosed as pulmonary tuberculosis by fibreoptic bronchoscopy was 21(5.8%). The sputum smears were negative for AFB in all these patients. Previous studies have shown the importance of fibreoptic bronchoscopy in suspected cases of tuberculosis where the sputum smear is negative. This study is further evidence of the importance of routine examination of bronchial wash for AFB in all cases undergoing fibreoptic bronchoscopy to detect atypical cases of pulmonary tuberculosis.

Bronchoalveolar Lavage Fluid↗
PubMed1993

Aspiration cytology of breast lumps.

The results of 287 aspirations performed on palpable breast lumps over a period of 20 months are presented. This is the first documentation of a Sri Lankan experience of this technique. The cytological assessment showed 52 malignant, 149 benign, 8 atypical, 6 suspicious and 72 inadequate aspirates. All lesions with a cytological diagnosis of malignancy were confirmed by histological assessment (False positives = 0). Histological follow up in 96 of the 149 cytologically benign lesions showed that 2 were malignant, giving a false negative rate of 2.1%. Three atypical lesions (37.5%) and four suspicious (66.2%) and 10 inadequate aspirates (13.7%) were also malignant.

Biopsy, Needle↗
PubMedDate not supplied

Cytology of granulomatous mastitis.

OBJECTIVE: To examine the cytologic features of granulomatous mastitis. STUDY DESIGN: Cytologic features of granulomatous mastitis (GM) are described as found on retrospective analysis of hematoxylin and eosin (H&E)-stained smears of nine breast lesions: eight fine needle aspiration biopsies and one imprint smear. All nine lesions were histologically confirmed. RESULTS: The aspirates were moderate or abundant. The H&E smears showed a distinctly inflammatory background with multinucleated giant cells (both foreign body and Langhans type), debris, neutrophils, macrophages, epithelioid cells and reactive epithelial cells. Special histochemical stains did not reveal any specific organisms. No foamy cells or caseation was seen. The four patients who presented for follow-up were free of disease after a minimum of 6 and maximum of 38 months. CONCLUSION: Although there are many entities mimicking GM, the cytologic pattern--consisting of multinucleated giant cells, debris, neutrophils, macrophages, epithelioid cells and reactive epithelial cells in the absence of foamy cells, caseation and demonstrable organisms--should prompt a diagnosis of GM.

Adult↗