[CO2-laser treatment of condylomata acuminata. Current clinical aspects].
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Adolescent↗
Biomedical subjects
M P Meandzija
Publications and source records attributed to M P Meandzija.
Analysis of electronically pulsed versus quasi-continuous wave carbon dioxide lasers in an animal model.
In this study we sought to compare laser tissue interaction in both the quasi-continuous waveform and electronically pulsed waveform of the carbon dioxide laser. An intramode analysis of the electronically pulsed form (at 350 and 650 pulses per second) was also undertaken. Intraperitoneal laser incisions were made on New Zealand white female virginal rabbits and tested at days 0, 5, 15, and 20. Testing involved proximal and midsection analysis of the laser sites to evaluate total area of vaporization, total area of tissue thermal damage, maximum diameter of injury at epithelial surface, maximum depth of laser penetration, angle of vaporization crater edges, and angle of tissue thermal injury of the three modes. Analysis of proximal versus midsection preparation revealed different zones of vaporization and injury within the same laser site. The zone of injury with respect to time was nonuniform, suggesting that the laser output in the electronically pulsed mode was not constant. An in vivo tissue lens phenomenon was also detected, resulting in a compound thermal vaporization and injury pattern.
Animals↗
CO2 laser conization versus conventional conization: a clinico-pathologic appraisal.
Two groups of patients recently underwent either laser or conventional conization at the University Women's Hospital in Bern, Switzerland. Of the total 49 patients treated, 25 underwent laser conization and 24 underwent conventional conization. All patients admitted to the study had cytologic, colposcopic, and/or histologic evidence for cervical intraepithelial neoplasia or chronic cervicitis resistant to conservative therapy. In the conventionally treated group, conization was performed with surgical scalpel, and hemostasis was achieved by Sturmdorff, Bonney, or Kraus sutures. In the laser-treated group, conization was performed by using the combination method of Dorsey and Grundsel. Blood loss was minimal in the laser-coned patients, compared to 119 ml blood loss in the conventionally coned patients. Hospitalization for the laser-treated group was 5.2 days in contrast to 7.0 days for the conventionally treated group. Postoperative bleeding and discharge were also considerably smaller or did not occur in the laser-treated group as compared to the conventionally treated group. With postoperative and long-term follow-up now under way, initial results indicate that laser conization, in comparison to conventional conization, also provides greater visibility of the squamocolumnar junction and a reduced incidence of cervical strictures. The results of this study suggest that the CO2 laser beam, properly and cautiously applied, is an efficacious surgical modality for the treatment of cervical preneoplastic disease.
Cervix Uteri↗