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Biomedical subjects

M P Nevitt

Publications and source records attributed to M P Nevitt.

5 recordsLinked to original sources
PubMed1993

Incidence of ulcerative keratitis in a defined population from 1950 through 1988.

OBJECTIVE: To determine the incidence of ulcerative keratitis and to assess trends in risk factors leading to ulcerative keratitis. DESIGN: Retrospective incidence cohort study. SETTING: General community. PATIENTS: Population-based sample of residents of Olmsted County, Minnesota, in the 39-year period between 1950 and 1988. MAIN OUTCOME MEASURE: Cases of ulcerative keratitis. RESULTS: One hundred forty-one cases of ulcerative keratitis were diagnosed among 131 residents (64 men and 67 women) of Olmsted County. The mean annual age-adjusted incidence per 100,000 people was 5.3 (95% confidence interval, 4.4 to 6.2). A 435% increase in the incidence of ulcerative keratitis was observed in Olmsted County residents from the 1950s (2.5 per 100,000 people) to the 1980s (11.0 per 100,000 people) (P = .001). The cases of ulcerative keratitis associated with contact lens wear increased from 0% in the 1950s and 1960s to 32% in the 1970s and 52% in the 1980s. CONCLUSION: The incidence of ulcerative keratitis has increased significantly in this community. Contact lens wear was the most important risk factor for the development of ulcerative keratitis during the last decade.

Adolescent↗
PubMed1992

Incidence of enucleation in a defined population.

We conducted a population-based study of long-term trends in the incidence of enucleation. From 1956 through 1988, enucleation was performed on 99 residents (55 males and 44 females) of Olmsted County, Minnesota. The mean annual age-adjusted incidence per 100,000 population for males (5.17) was 50% greater than that for females (3.49; P = .04). An increase in the enucleation rate was noted with increasing age (P = .001), with the highest incidence in patients who were 70 to 79 years of age. A decrease in the incidence of enucleation over time (P = .002) was observed in Olmsted County residents who were at least 40 years of age and was caused primarily by the decreasing incidence of neovascular glaucoma and tumor-related enucleations. The incidence of traumatic enucleations did not significantly decrease (P = .25) over this three-decade study period.

Adolescent↗
PubMed1989

Prognosis of abdominal aortic aneurysms. A population-based study.

Information is incomplete about the rate of expansion of abdominal aortic aneurysms and the risk of rupture in relation to their size. To address these questions, we conducted a population-based study. Of the 370 residents of Rochester, Minn., with an aneurysm initially diagnosed from 1951 through 1984, 181 had the aneurysm documented by ultrasound examination. Among the 103 patients who underwent more than one ultrasound study, the diameter of the aneurysm increased by a median of 0.21 cm per year. Only 24 percent had a rate of expansion of 0.4 cm or more per year. Among the 176 patients who had an unruptured aneurysm at the time of the initial ultrasound study, the cumulative incidence of rupture was 6 percent after 5 years and 8 percent after 10 years. However, the risk of rupture over five years was 0 percent for the 130 patients with an aneurysm less than 5 cm in diameter and 25 percent for the 46 patients with an aneurysm 5 cm or more in diameter. All 16 patients who had ruptures had aneurysms that were 5 cm or more in diameter at the time of the rupture. These population-based data challenge the clinical perception that aneurysms typically expand at a rate of 0.4 to 0.5 cm per year. Our data also suggest that for aneurysms less than 5 cm in diameter the risk of rupture is considerably lower than has been reported previously. However, the risk of rupture is substantial for aneurysms 5 cm or more in diameter.

Aorta, Abdominal↗