[Role of metabolic arachidonic acid cascade and prostaglandin E2 in the pathogenesis of immunodeficiency in traumatic shock and acute hemorrhage].
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Acute Disease↗
Biomedical subjects
M P Pavlovskiĭ
Publications and source records attributed to M P Pavlovskiĭ.
[Effects of prostacyclin MM-706 on liver function restoration in dogs after severe hemorrhagic shock].
The new synthetic analogue of prostaglandin I2 (prostacyclin MM-706) influence on some hepatic function indexes was studied up in 7 dogs with an acute hepatic insufficiency caused by severe hemorrhagic shock. Rapid and steady normalization of indexes and the animals survival were promoted by intravenous infusion of MM-706 given in 300 ng/kg dose together with hemocorrector named lactoprotein given in 10 ml/kg dose (7,5 +/- 1,4) hours later. Possible action mechanisms of the MM-706 therapeutic efficacy are considered. Results of investigation performed constitute an experimental base of the MM-706 application in the complex treatment of an acute hepatic insufficiency of different genesis in the clinic.
Animals↗
[Contents of prostaglandins F2alpha, I2 (prostacyclin) and thromboxane A2 in the dog liver during development of hemorrhagic shock].
Contents of prostaglandins (PGs) F2 alpha, I2 and thromboxane (TH) A2 in the liver of 6 dogs has been studied in dynamics of hemorrhagic shock development. The results show that acute haemorrhage (31.9 +/- 1.6 ml/kg) stimulates the synthesis and release of all the eicosanoids studied. Nevertheless, in the progression of shock a significant difference was noticed between the high TXA2 and PGF2 alpha rates and comparatively lower rise of PGI2 production. The late stage of shock (201 +/- 44 minutes after haemorrhage) was characterized by a further rise in TXA2 and PGF2 alpha rates with simultaneous lowering of PGI2 as a result of vascular endothelium affection which is the main source for prostacyclin synthesis. In view of the antagonism of PGI2 to TXA2 and PGF2 alpha and its cytoprotective effects, the results of present investigation give the experimental background for using prostacyclin or its synthetic analogues in a complex therapy of acute liver failure in clinic.
Animals↗
[The clinico-morphological characteristics of thyroid cancer in a region of endemic goiter].
The study deals with the results of clinico-morphologic analysis of thyroid cancer in 351 patients who have been operated on in the Carpathian Mountain [correction of Prikarpatsky] region endemic for goiter over the period of 25 years. Certain peculiarities of thyroid cancer were established: relatively high occurrence of the disease, specific ratio of basic histologic subtypes, high frequency of early stage cases and regular concomitance of cancer with other thyroid pathologies. The importance of further studies into the epidemiology of thyroid cancer is emphasized.
Adenocarcinoma, Follicular↗
[Use of allograft of pancreatic islet cell cultures in complex treatment of acute purulent process in patients with diabetes mellitus].
The results of treatment of 170 patients with diabetes mellitus and purulent wounds which appeared after opening the abscesses and phlegmons, and as well of 270 patients with gangrene of the lower extremities are presented. Early opening the abscess, improved quality of debridement of purulent wounds, and as well allotransplantation of pancreatic islet cell cultures (45 cases) permitted to stop progressing of the purulent process, place early secondary sutures, and in patients with the sutures placed, to achieve primary healing of the wounds.
Abscess↗
[Treatment tactics in nodular forms of goiter].
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Diagnosis, Differential↗
[Intraportal allogeneic transplantation of the islets of Langerhans cultures in the complex treatment of surgical patients with diabetes mellitus].
The article presents results of treatment of 21 patients with a surgical pathology and diabetes mellitus who had intraportal allotransplantation of cultures of islet cells of the pancreas and 316 patients with the similar surgical pathology without such transplantation. It was found that the intraportal introduction of islet cell cultures into the liver can result in an early and considerable drop of the injected insulin dose which is very important in the postoperative period. This method allowed to make the period of treatment at the hospital approximately 15 days shorter.
Adult↗
[Long-term results of allotransplantation cultures of pancreatic islets cells].
Under study were long-term results of transplantation of cultures of islet cells of the pancreas of human fetuses in 95 patients. A marked antidiabetic effect of transplantation was noted in 89 recipients. A conclusion was made that recipients with diabetes of the middle and first stages are not very perspective for intramuscular transplantation of the islet cell cultures of the pancreas. The most pronounced antidiabetic effect of transplantation was observed in patients with a severe form and labile course of diabetes mellitus with ketosis and ketoacidosis.
Cells, Cultured↗
[Substantiation of indications for surgical and drug treatment of chronic diseases of the liver].
In the diagnosis of chronic liver diseases, the important place belongs to the evaluation of the immune status, indices of energetic metabolism. The preference should be given to the non-invasive instrumental methods. Drainage of the bile ducts is indicated in chronic active hepatitis and primary biliary liver cirrhosis. Desympathetization of the hepatic artery is not always effective. The indications for splenectomy are limited, in its performance, a splenic homogenate should be placed into the omental sac, or retroperitoneal space. For prevention of failure of the portocaval anastomotic sutures, the hepatic arterialization is expedient. The methods of sorption detoxication and laparoscopic laser therapy improve the results of treatment.
Drainage↗
[Clinical aspects of allotransplantation of the pancreatic islet cells in patients with diabetes mellitus and acute and chronic cholecystitis].
The results of treatment of 25 patients with acute and chronic cholecystitis accompanied by diabetes mellitus, who underwent transplantation of the pancreatic islet cells (PIC), and 40 patients with identical pathology, who underwent no PIC transplantation, are presented. In chronic cholecystitis and diabetes mellitus with the aim of preparation for the operation, PIC were administered intramuscularly, in acute cholecystitis and diabetes mellitus intraportally, after cholecystectomy. Transplantation of the PIC cultures in patients with diabetes mellitus contributes to correction of the impaired metabolic processes, reduction of the incidence of postoperative complications.
Adolescent↗
[Ultrasonography of the abdominal cavity organs in peptic ulcer patients following gastric resection].
A study of 205 patients in the follow-up period after gastric resection for ulcer disease indicates that ultrasonography is a valuable method of diagnosis of involvement of the abdominal cavity organs but requires perfection of methods directed at improvement of visualization of the scanned organs. For diagnosis of diffuse lesions of the liver it is rational to combine ultra-sonography with radionuclide, endoscopic and roentgenological methods. It was found that patients with gastric resection syndromes, calculosis of the gallbladder was present in 17.1% while lesions of the pancreas were 4 times more frequent than in the common population.
Abdomen↗
[Cytopathomorphism of the thyroid].
Despite the successes in anti-goitre actions, the problem of thyroid pathology still remains to be of high complexity and concern. Research conducted in the endemic goitre focus in the Pre-Carpathians indicated the presence of pronounced pathomorphosis of thyroid abnormalities. The incidence of autoimmune and malignant conditions is growing, so is that of Hürthle cell metamorphosis in the thyroid epithelium. New variant forms of already known diseases have appeared. The findings would help perform an adequate correction of diagnostic, therapeutic, and preventive measures. A profound research into the thyroid gland abnormalities is essential.
Cell Transformation, Neoplastic↗
[Disorders of the motor and evacuatory functions of the stomach and duodenum in peptic ulcer patients].
Complex examination of 73 patients with ulcer disease (bulbus duodeni location) revealed regularities of evacuation of a test breakfast from the stomach depending on the phase of the disease. Significant disorders of the motor-emptying gastric and duodenal function were found that are to be considered in the treatment of this category of patients.
Adult↗
[Malignization of goiter].
From analysis of literature data and the results of their personal studies embracing 3,139 operations for diseases of the thyroid gland the authors conclude that certain forms of goiter (nodular and recurrent in particular) play regularly the role of background processes in the development of cancer of the gland. This provides the ground for setting apart such patients into a risk group. Marked dysplasia is the main form of precancerous changes.
Adenoma↗
[Reserves for improving early diagnosis of acute surgical diseases of the abdominal organs at the pre-hospital stage].
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Abdomen, Acute↗
[Peptic ulcer recurrence after vagotomy].
The authors studied the clinical aspects, indices of gastric secretion and basal level blood serum insulin, gastrin and parathormone in 83 patients with ulcer disease recurrence after vagotomy. All patients showed an active acidopeptic factor--sequel of ineffective and incomplete (in some patients) vagotomy as well as inadequate pyloroplasty. Provoking factors of ulcer disease recurrence may be stress, drugs, duodenogastric reflux, presence of ligatures after pyloroplasty. Surgical treatment is indicated in patients with surgical complications, repeatedly relapsing ulcers. Recurrences with moderate course are successfully treated by traditional means and the patients retain working capacity due to seasonal or all-year prophylaxis.
Adult↗
[Problems of training family practitioners].
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Education, Medical↗
[Experience in training of general practitioners].
The pedagogical experiment indicated that the effective training of general practitioners could be realized through the system of intern and resident training which made it necessary to prolong the term of study up to 12 weeks for interns in the out-patient departments and up to 4 months for resident physicians. The retraining of district therapists enabling them to work as general practitioners could be successfully effected at the departments of advanced medical training in the course of 5 months.
Education, Medical, Graduate↗