[Halofantrine overdosage].
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Biomedical subjects
Publications and source records attributed to M P Vincent.
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Spontaneous pneumothoraces occur in patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. However, treatment with tube insertion and tetracycline sclerosis often fails to prevent recurrence. We present a single case of such a patient successfully treated with talc sclerosis.
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Skin grafting remains a primary modality for reconstruction of genitourinary defects. Many of these conditions are discussed and emphasis has been placed on the different indications for full-thickness, split-thickness, and dermal grafts. Complications have been few, and long-term results excellent. This experience has allowed the formulation of a number of surgical principles, which are presented. Refinements in reconstruction are currently being evaluated to obtain the optimal result.
An urgent closure of myelomeningocele defects was carried out in 82 newborns using latissimus and/or trapezius musculocutaneous advancement flaps. A three-layer closure of skin, muscle, and fascia was achieved in a single stage without a flank skin graft. All of the wounds healed within a two-week period and no late breakdown of the wound occurred during the eight-year period of study. The urgent closure maximized the neurological salvage and facilitated early cerebrospinal fluid shunting by preventing both infection and neural desiccation. This report represents the largest number of sequentially treated myelomeningocele defects without a major wound healing problem or death. The advancement musculocutaneous flap closure is safe, simple, and effective and is recommended as the preferred method for closure of the myelomeningocele defect.
This study has provided baseline data of a quantitative neurophysiological appraisal of normal breast sensibility using our current understanding of cutaneous mechanoreceptive function. Test variables, including pressure, low- and high-frequency vibration, static and moving two-point discrimination, temperature, nipple erectibility, and pain, were evaluated in 11 normal volunteers using different coordinates over the nipple, areola, and body of the breast. Definite patterns were established so that the breast could be subdivided into distinct cutaneous areas with differing mechanoreceptive characteristics. The future aim is to broaden the scope of this study with preoperative evaluations in our clinical patients so that appropriate recommendations for future reconstructive breast procedures can be made.
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