Biomedical subjects
Publications and source records attributed to M P Zhukova.
The paper provides the data on the spread of drug-resistant strains of Mycobacterium tuberculosis (MBT) among contingents of patients with pulmonary tuberculosis who have been registered at a dispensary and new cases. The spread was 42.5 and 20.0%, respectively. In the past 3 decades, the spread of primary (baseline) drug resistance of MBT has increased from 6.5 to 22.0%.
To form contingents of pulmonary tuberculosis patients with isolated drug-resistant Mycobacteria tuberculosis (MBT) strains, chronic patients having the disease for more than 3 years (50.3%) head the list, new cases (36.9%) detected in the past 3 years (1994-1996) rank second, next are those with relapsing tuberculosis (12.8%) identified in 1994-1996. The ratio of the above group of patients with isolated drug-sensitive MBT species is 23.3, 68.8, and 7.9%, respectively.
The paper provides the results of follow-ups of 269 patients with pulmonary tuberculosis, 170 and 39 isolated drug-resistant or sensitive Mycobacteria tuberculosis (MT), respectively. Drug resistance to MT was found to lower the feasibility of curing the patients, to prolong their cure, and to slow down the rate of decreasing the cohort of tuberculosis patients registered at the dispensary. In the first 5-years of the follow-up, there were lower death rates due to tuberculosis in a group of patients with drug-resistant MT than in those with drug-sensitive one.
The problems of detection and treatment of patients with tuberculosis, which are of paramount importance for today, are presented through the analysis of the tuberculosis epidemic situation in the country and of the sociomedical characteristics of new cases (49% of socially disadapted persons). Of the most significance is the need to promptly identify patients with strains on their referral to the general somatic hospitals for complaints by using 3-multiple sputum bacterioscopy for Mycobacterium tuberculosis by the Ziehl-Neelsen method. The vital problem is also to change chemotherapeutical regimens as more severe progressive types of the disease require more active treatment in the first months after detection especially in the cohort of socially disadapted persons.
By analyzing the present-day tuberculosis epidemiological situation in the country and sociomedical characteristics of new cases, the authors present methods for detecting and treating patients, which are of paramount importance for today. Of the most significance is the need to promptly identify patients with strains on their referral to the general somatic hospitals for complaints by using 3-multiple sputum bacterioscopy for Mycobacterium tuberculosis by the Ziehl-Neelsen method. The vital problem is also to change chemotherapeutical regimens as more severe progressive types of the disease require more active treatment in the first months after detection especially in the cohort of socially disadapted persons.
Data on tuberculosis morbidity covering the period 1950-1989 are presented: special features of tuberculosis epidemiology for the studied period are emphasized; grouping of the republics is given by tuberculosis morbidity rates and pattern; difficulties encountered in tuberculosis prevention and detection are discussed which can adversely affect the decline of tuberculosis mortality rates.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.