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Biomedical subjects

M Pérez-Miranda

Publications and source records attributed to M Pérez-Miranda.

17 recordsLinked to original sources
PubMed2000

Cluster of MMPI personality profiles in chronic tension-type headache and predictable response to Fluoxetine.

A study was made of the personality profiles of a sample of 51 patients with chronic tension-type headache (CTH) employing the Minnesota Multiphasic Personality Inventory (MMPI). Two clusters were obtained by applying multivariate classification techniques: cluster 1 (with elevations on scales Hy, D and Hs only) and cluster 2 (exhibiting elevations on most scales except Pd, Mf and Si). Fifty subjects without chronic pain or known psychiatric disorders, and extracted from the same social setting as the patients, completed the MMPI as a control group. Fluoxetine treatment was started in the CTH group, with follow-up over a 1-year period. Chi-squared analysis correlating the clusters obtained to different pain-related variables and epidemiological parameters revealed a significant association to sex only. There were no differences in therapeutic response between the two clusters. However, the patients belonging to the less perturbed cluster who exhibited profiles analogous to those of the control population showed significant improvement with respect to the global sample and their own cluster.

Adult↗
PubMed2000

Incidence of type I diabetes among children and young adults (0-29 years) in the province of Badajoz, Spain during 1992 to 1996.

In this study, we determine the incidence of Type I (insulin-dependent) diabetes mellitus in the 0-29-y-old group in Badajoz (the largest and least developed province of Spain). We test for differences in incidence by age at diagnosis, time cluster and sex. Diabetes clinics and periodic review of hospital administration data provided the primary source of ascertainment. The secondary independent data source was based on registries of local Diabetic Associations and guarantee cards of blood glucose meters. Data were collected retrospectively in the period 1992-95 and prospectively for 1996. During the 5-y period (1992-96), 186 new cases of Type I diabetes were identified. Completeness of ascertainment was 95%. Average annual incidence (95% CI) for the 0-14, 15-29 and 0-29-y-old groups was 17.6/100,000 (14.5-21.2), 8.8/100,000 (6.9-11.1) and 12.8/100,000 (11-14.7). The highest age-specific annual incidence rate was found in the 10-14 age group: 23.4/100,000 (17.6-30.4). The incidence in males (14.7/100,000/y) was higher than in females (10.7/100,000/y). There was a seasonal onset pattern, with the highest incidence in autumn and winter. October was the month with the highest number of new cases (29/186). The province of Badajoz has a moderately high incidence of Type I diabetes in 0-14-y-old children, similar to that found in other more developed and densely populated regions of Spain. These data contradict the hypothesis of a decrease in the incidence of the disease from north to south over Europe.

Adolescent↗
PubMed1999

Estimated incidence of inflammatory bowel disease in Argentina and Panama (1987-1993).

AIM: to estimate the incidence of inflammatory bowel disease (IBD) in two areas from Panama and Argentina. METHOD: during a 7-year period from 1987 to 1993 we surveyed IBD in two well-defined communities from Panama (District of Colón) and Argentina (Partido General Pueyrredón). The mean annual incidence of IBD was estimated from hospital-based registries. Records from the General Records Department and the endoscopy, radiology and pathology services were reviewed at the Hospital MA Guerrero in Colón and at two other hospitals in Partido General Pueyrredón to identify suspected cases of IBD. Cases were confirmed using standard criteria, and disease incidence rates were calculated by dividing the number of cases in which a positive diagnosis could be established by the population served by each hospital. RESULTS: mean annual incidence of ulcerative colitis in Panama was 1.2/100 000 inhabitants/year, and no cases of Crohn's disease (CD) could be diagnosed. Mean annual incidence of IBD in Partido General Pueyrredón was 2.2/100 000 inhabitants/year, with only a single case of CD being identified. We argue that such figures could represent a good estimate of the incidence of IBD in each area, given the wide coverage of the population by the hospitals surveyed in each region. CONCLUSION: according to these results, the incidence rates of IBD seem to be much lower than those published for other "Hispanic" communities outside Latin America. Factors such as population structure, environment or genetic determinants might account for these differences.

Adult↗
PubMed1999

Carcinoma of the extrahepatic biliary tree: analysis of 15 cases.

AIM: to analyze the epidemiology, prognosis and treatment of those diagnosed as having cholangiocarcinoma of the extrahepatic biliary tree. METHODS: a prospective study including all cases diagnosed over a period of 26 months. Fifteen patients with primary bile duct carcinoma were included. RESULTS: the incidence rate was 3.23 cases/10(4). The tumor locations were: 40% proximal bile duct, 33% distal bile duct, and 27% mid-duct. The treatments used were: curative resection in 1 case (7%); palliative surgery in 3 cases (20%); internal drainage through a prosthetic biliary stent by endoscopic retrograde cholangiopancreatography in 6 cases (40%) and by percutaneous transhepatic cholangiography in 2 cases (13%); external bile drainage in case (7%), and in the remaining 2 patients (13%) no treatment was possible. The 1-month, 6-month and 10-month survival rates were 67%, 40% and 33% respectively. Factors associated with a worse survival in this study were age over 70 years and female sex. The worst prognostic location was the mid-duct compared to the distal and proximal thirds. CONCLUSIONS: the incidence of the primary bile duct carcinoma is high in our population. The commonest location is the proximal bile duct. Curative surgical resection is possible in only a few cases, and thus the overall prognosis is very bad.

Aged↗
PubMed1996

Endoscopic anal dilatation for fissure-in-ano: a new outpatient treatment modality.

We describe a new therapeutic procedure for fissure-in-ano, endoscopic anal dilatation. Anal dilatation is performed with a two-valved anoscope under local anesthesia in an ambulatory setting. We report our results using this technique in 62 patients after a mean follow-up of 19 months (range: 12-24 months). Thirty days after the procedure, 55 patients (93%) were symptom-free, whereas 3 of them (4.8%) failed to improve. After nineteen months, one patient out of 47 in follow-up had a recurrence. No bleeding, discharge or defects of continence, either transient or permanent, were noted. The results of endoscopic anal dilatation are comparable with those of lateral sphincterotomy, can be achieved at a lower complication rate, with only minor and temporary complications, and performed by physicians with no specific surgical training.

Adolescent↗
PubMed1980

[Fibrin-fibrinogen degradation products in cerebrospinal fluid of patients with meningococcal infections (author's transl)].

Fibrin degradation products (FDP) D and E, total protein, cell count, and alpha-1-antitrypsin levels have been measured in the cerebrospinal fluid (CSF), and FDP-D and E, and alpha-1-antitrypsin analyzed in serum in 13 cases of meningococcal disease, six with meningococcal septicemia and seven with meningitis. Neisseria meningitidis serotype B was the responsible agent in all cases. The following conclusions are obtained: 1) The presence of FDP in the CSF has no prognostic value, and its detection only in plasma does not exclude a fatal outcome. 2) Statistical analysis of the data suggests that the presence of FDP in the CSF is not the result of passive transfer from plasma but it indicates a meningeal inflammatory reaction. 3) Alpha-1-antitrypsin levels are elevated in meningococcal infections both in plasma and in the CSF, and they significantly correlate with the intensity of the fibrinolytic activity.

Fibrin Fibrinogen Degradation Products↗