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Biomedical subjects

M PICKFORD

Publications and source records attributed to M PICKFORD.

At least 19 recordsLinked to original sources
PubMed1961

The persistence of a depressor response to oxytocin in the fowl after denervation and blocking agents.

The effects of oxytocin and vasopressin on the blood pressure of the fowl have been studied after surgical or chemical interruption of parts of the central and peripheral nervous systems, and after the administration of stilboestrol and progesterone. An augmented and prolonged depressor response to oxytocin was seen after atropine, bretylium, tetraethylammonium or decapitation, but not after decerebration, dihydroergotamine or dibenamine. There was a tendency for the pressor action of vasopressin to disappear after decapitation, decerebration, and all the blocking agents used, except tetraethylammonium. The differences between these results and those which have been obtained in rats are discussed.

Animals↗
PubMed1959

Comparison of effects of valyl(3)-oxytocin and syntocinon on the cardiovascular system of man.

Valyl(3)-oxytocin has similar circulatory effects in man to those of Syntocinon (synthetic oxytocin). On intravenous administration, it caused a rise in limb blood flow and in pulse rate and a fall in blood pressure. It had a direct vasodilator effect on limb blood vessels. Valyl(3)-oxytocin was 1.5 to 2 times more potent than Syntocinon in terms of its circulatory effect in man. The circulatory effects of valyl(3)-oxytocin were less readily antagonized by vasopressin than are those of Syntocinon.

Administration, Intravenous↗