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Biomedical subjects

M Pach

Publications and source records attributed to M Pach.

5 recordsLinked to original sources

Fluorescent advanced glycation end products in the detection of factual stages of cartilage degeneration.

Patients treated for knee disorders were included in this study. They were examined clinically (Lequesne and Tegner scores) and by standard X-ray investigation. Patients underwent a surgical procedure, either arthroscopy or knee replacement. At the initial phase of surgery, a sample of cartilage was taken for laboratory examination. Progression of the disorder and the clinical examination was correlated with the actual state of the cartilage using a novel fluorescence approach. The intrinsic fluorescence of cartilages was shown as a suitable and sensitive method for detection of the actual state of cartilages because the correlation with X-ray examination and clinical status was found. Intrinsic fluorescence properties of cartilages from patients with chondropathy and osteoarthritis were described and found to be age-dependent. We also observed a higher concentration of advanced glycation end products due to inflammatory and/or degenerative processes in the cartilage. In addition, acute pathological changes due to diseases such as meniscal lesions or anterior cruciate ligament rupture caused a significant increase of formation of advanced glycation end products even in the group of young patients. In fact, such an observation could be crucial and important for the detection of knee conditions suspected of early meniscal and/or ACL lesions especially among young patients.

Adolescent↗

[Varus supracondylar osteotomy of the femur -- long-term results].

PURPOSE OF THE STUDY: Varus supracondylar osteotomy of the femur is the surgical procedure indicated in young patients with symptomatic unicompartmental gonarthrosis associated with a valgus knee deformity. The aim of the study was to evaluate long-term results and to draw attention to the most frequent mistakes in the indication and surgical technique. MATERIAL: In the period from 1985 to 1995, 35 knees in 33 patients were treated by varus supracondylar osteotomy of the femur in the Department of Orthopedics, Teaching Hospital, Faculty of Medicine, Palacký University in Olomouc. The technique of medial closing wedge osteotomy of the distal femur held with a 90 degrees plate was used. For post-operative immobilization, a brace was applied in most of the patients. METHODS: The information recorded was as follows: age, type of arthritis, follow-up period, preoperative tibio-femoral angle, postoperative tibio-femoral angle, range of motion before and after surgery, post-operative Knee Society scores, complications, number of osteotomies converted to total knee arthroplasty, and time between osteotomy and knee prosthesis implantation. The survival of osteotomy was evaluated by the Kaplan-Meier analysis for censored data. The change in parameters obtained before and after surgery was assessed by the one-sample t-test and non-parametric Wilcoxon test. RESULTS: All 35 knees were evaluated. The average Knee Society score at follow-up was 77 points (range, 61-95), the average functional knee score was 78 points (range, 61-95). The average range of motion increased from the pre-operative 112 degrees (range, 75-130 degrees ) to post-operative 115 degrees (range, 90-135). This difference was statistically significant (p = 0.032; t-test for paired samples; Wilcoxon test). The average follow-up was 14.7 years (range, 10-20 years). The most frequent complications were progression of medial compartment arthritis (8 knees), loss of correction (6 knees) and arthrofibrosis (5 knees). Osteosynthesis failed in two knees and, in two, superficial wound infection was recorded. Due to failure of osteotomy, six patients (17 %) subsequently underwent total knee replacement. The osteotomy survival rate was 95% at 18 years (CI, 16-19 years). DISCUSSION: The results of this study are based on long-term observation and can be compared with the studies by Mironneau et al. or Finkelstein et al. These and other authors have achieved better results in terms of score values, which can be explained by the following five factors: the follow-up in their studies was significantly shorter than in our study. At our department knee arthroplasty became a routine surgical technique as late as the early 1990s, and even after that some tendency continued to indicate bi- and tri-compartmental osteoarthritis for osteotomy. Also we operated on patients who were overweight and on those who were older than recommended for this procedure. CONCLUSIONS: The prerequisite for successful varus supracondylar osteotomy of the femur in unicompartmental gonarthrosis is that the patient is active, younger than 62 years and is not overweight. Early diagnosis followed by osteotomy, which prevents further progression of the disease, is also important. The detailed pre-operative planning and exact performance of the procedure are fundamental conditions. In the post-operative period it is necessary to observe the relevant regimen including rehabilitation therapy. When these conditions are fulfilled, osteotomy can markedly postpone the necessity of total knee arthroplasty.

Adult↗

Our experience with 3D CT.

The authors present the results of 9-year work with 3D CT in orthopaedics and musculoskeletal traumatology. In the years 1990-1998, the method was used in the examination of 59 patients (27 males, 20 females, and 12 children). The place of 3D CT in clarifying areas of complex musculoskeletal anatomy for operative treatment is discussed and presented as a contribution to the indication conference. According to the authors' experience, in many cases 3D CT increases the quality of diagnostics. Most of all, it helps the surgeon in operation planning. 3D reconstructions are particularly valuable in proximal humerus fractures, spine fractures and tumours, acetabulum fractures, as well as in conditions after hip dysplasia, LCPD and coxa vara adolescent.

Adult↗

[Calve-Legg-Perthes disease].

The authors present in a review contemporary views on the pathogenesis, classification and diagnosis of Perthes disease. At the same time they indicate possible therapeutic interventions and discuss their justification. They emphasize the demand of close collaboration of the paediatrician and orthopaedic surgeon.

Child↗

[Subcapital osteotomy of the femoral neck in the treatment of coxa vara in adolescence--long-term results].

The authors present a group of 16 adolescents suffering from coxa vara treated in the years 1967-1987 for a severe slipped capital femoral epiphysis by subcapital osteotomy. The authors deal with the etiology, symptomatology and treatment with special regard to the severe slip. Spica cast was applied in most operations and no internal fixation was used. In the so far latest female patient the femoral head was fixed after osteotomy by Kirschner wires according to Dyas Aries. In the discussion the authors report considerably lower percentage of complications in the longterm examination, mainly as concenns the avascular necrosis of the femoral head in comparison with most works presented both in the Czechoslovak and foreign literature. These results are explained by a proper indication, prepping technique, adequate operative technique and a consistent adherence to longterm nonweight of the extremity operated on. Preventive epiphyseodesis on the intact hip joint has not been performed.

Adolescent↗