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PubMedDate not supplied

Diabetic autonomic neuropathy and bladder function: pharmacological use of gangliosides and insulin.

This paper briefly describes experimental evidence indicating that bladder dysfunction observed in diabetic rats is due in part to hyperdiuresis and in part to autonomic nerves alterations. The latter, in analogy with somatic nerves alteration, can be ameliorated by treatment of diabetic animals with gangliosides. The use of this agent in the autonomic nerve dysfunction of diabetic origin is discussed.

Animals↗

PubMedDate not supplied

Alterations of the vegetative nervous system, experimental diabetes and pharmacological use of gangliosides.

We studied in diabetic animals several variables related to the vegetative innervation of the heart and the urinary bladder. Cardiac content of norepinephrine was lower in the heart of the diabetic mice (db/db) as compared to the heart of their heterozygote littermates (db/m). Bladder responses were clearly altered in alloxan treated rats as compared to normal rats, as shown by an increased vesical weight, an increased threshold for micturition reflex and a reduced rate of rhythmic contraction. Ganglioside administration was able to prevent partly or completely these alterations observed in the diabetic animals.

Alloxan↗