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Biomedical subjects

M Passatore

Publications and source records attributed to M Passatore.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Muscular dystrophy in mice after chronic subcutaneous treatment with cannabinoids.

Swiss male albino mice were treated subcutaneously with the main cannabinoids (CBN, CBD, delta9-THC) at the dosage of 1 mg/kg per day for 30 days, and with the crude resin. At the end of the treatment, after supramaximal stimulation of the sciatic nerve, a significant decrease of both maximal twitch and tetanus tensions was observed in delta9-THC-treated animals; CBD and resin treatment produced some decrease in active tension, while CBN treatment induced an enhancement of the contractile strength. Histology showed lesions interpretable as due to muscular dystrophy. Analysis of protein and hydroxyproline muscular content showed a marked reduction in protein in all treated animals, with a corresponding high increase in hydroxyproline content.

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PubMedDate not supplied

Anti-fatigue action exerted by the sympathetic nervous system in the rabbit digastric muscle.

Stimulation of the cervical sympathetic trunk, at frequencies within the physiological range, consistently elicits a partial recovery of the contractile force in the fatigued digastric muscle. This action, together with the tension potentiation induced by the sympathetic system in the non-fatigued muscle, could improve the muscular performance under the physiological conditions associated with increase in the sympathetic outflow.

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PubMedDate not supplied

Spontaneous sympathetic command to skeletal muscles: functional implications.

The sympathetic system can influence skeletal muscle function through an action exerted at the peripheral level, namely on muscle spindle afferent information and muscular contraction. Data supporting such a conclusion are briefly reviewed. Also, the results described in the present paper suggest that the sympathetic nervous command affecting muscle function is tonic in nature and that it can be modulated by inputs which are known to influence other sections of the sympathetic system.

Afferent Pathways↗
PubMedDate not supplied

Effect of cervical sympathetic nerve stimulation on nociceptive jaw opening reflex in the cat.

In anaesthetized cats the electrical stimulation of the cervical sympathetic nerve induces a considerable increase (150-250%) in the nociceptive jaw opening reflex elicited by tooth pulp stimulation (JOR). The mechanisms potentially responsible for this effect are discussed and the possibility is suggested, that a portion of the response is due to a modulatory action exerted by the sympathetic on the nociceptive input.

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