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Biomedical subjects

M Pawlus

Publications and source records attributed to M Pawlus.

4 recordsLinked to original sources
PubMed1985

Effect of cadmium chloride on the ovulation and structure of ovary in the inbred KP and CBA mice strains.

A single dose of cadmium chloride (2.2 mumol/100 g of body weight) brought about in the sensitive KP strain alterations of the ovarian structure and disturbances in the ovarian cycle manifested by a prolongation of diestrus. Following cadmium administration and increase in the amount of atretic follicles, especially those showing stages 1I and 2II of degeneration, was observed in the ovaries of KP mice. The corpora lutea contained numerous degenerated cells and were infiltrated by abundant connective tissue cells. The used dose of cadmium chloride showed no influences upon progesterone level. The absence of changes in the ovarian morphology and in the duration of the oestrus cycle in CBA females suggest that this strain is resistant to cadmium chloride.

Animals↗
PubMed1983

Genetic differences in mouse adrenocortical structure.

The adrenal structure was studied in three inbred mice strains: KP, KE, and CBA. In adult females the adrenal weight and size was higher than in males from the respective strains. It resulted from the higher adrenocortical volume in females, from the higher volume of particular adrenocortical zones and from the presence of an undegenerated x-zone. In the KE females the x-zone deserves a particular attention because of its unusual morphology, different from that observed in females from the other strains. Significant differences were found between the investigated strains in the volume of particular adrenocortical zones, as well as in the number and size of the adrenocortical cells. The above differences were confirmed by the morphometric and sterereologic analysis using Weibel's method.

Adrenal Cortex↗
PubMed1979

Inheritance of sensitivity to cadmium induced testicular damage in mice.

Testicular damage induced by cadmium in inbred mouse strains was evaluated on the basis of the thickness of tunica albuginea and histological images of the seminiferous tubules and the interstitial tissue. While comparing the thickness of the tunica in the untreated KP, C57 and CBA males as well as in F1 (KP x CBA) and B1 (KP x CBA) x CBA, the authors found it to be inherited in a simple Mendelian way. The thin tunica of the sensitive KP and C57 strain males became markedly thickened after injected with cadmium chloride. On the contrary, no changes were observed in the resistant CBA strain males which are characterised by a thick tunica. The results corroborate Taylor's [10] hypothesis that resistance to the damaging effect of cadmium is controlled by a single autosomal recessive gene. In addition, it is suggested that thickness of the tunica is positively correlated with the resistance to the action of cadmium.

Animals↗