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Biomedical subjects

M Peña Fernández

Publications and source records attributed to M Peña Fernández.

4 recordsLinked to original sources

[Tuberculosis outbreak at a public school].

BACKGROUND: At school there are special circumstances of living together and a particular susceptibility, which favour the emergence of tuberculosis microepidemics. We report here the microepidemic occurred at a school among 9-year old children. METHODS: After ruling out a possible familiar source in a child with pulmonary tuberculosis, we detected a case with high bacillar shedding in a female teacher and conducted a tuberculin search among children and teachers, initially outlining the theoretical groups at risk. Tuberculin positive children underwent chest-X-ray and when abnormalities were found, children were derived to the pediatrician for chemotherapy. All converters received secondary chemoprophylaxis and all non-respondents primary chemoprophylaxis. RESULTS: The classroom where the teacher spent most of het time had a higher rate of converters (70%) than other classroom, where the index teacher spent only a partial time (40%; RR: 1.75; CI: 1.06-2.88) or the collective of teachers (45.4%; RR: 1.45; CI: 0.94-2.23). Three additional cases of secondary disease were detected, all of them children. The initial compliance with chemoprophylaxis was greater among (for) children (97.0%) than among teachers (41.6%). Among children there was one case of tuberculin conversion compared with three cases among teachers. No additional cases were detected; also, an abnormal rate of reactors outside the initially studied groups was also not detected. CONCLUSIONS: Our results somehow agree with those reported from other school outbreaks. To note the anergy and lack of symptoms in the index case and the suggestion to delineate the degree of spending hours together to identify groups with a higher theoretical risk of being infected. Thus, an unnecessary expense of resources and a social alarm would be avoided.

Adult↗

Hepatitis B vaccine immunoresponsiveness in adolescents: a revaccination proposal after primary vaccination.

Hepatitis B recombinant vaccine immunoresponsiveness was studied in 427 preadolescents vaccinated with a 0, 1 and 6 months vaccination schedule. AntiHBs postvaccination titres (measured one month after the last dose) were related to the following variables: sex; weight; height; and Quetelet index. The antiHBs postvaccination titres were used to predict the length of protection induced by the vaccine. All preadolescents developed antiHBs titres 10 IU l-1 and no statistically significant differences could be found between sexes. The relation study between antiHBs postvaccination levels and Quetelet index showed a statistically significant inverse correlation. According to the antiHBs postvaccination titres, the central 50% of the sample distribution would be protected during a period between 7.5 and 10.5 years. In pre-teenagers, the hepatitis B recombinant vaccine has proven to be highly immunogenic, obesity is a predictor of poor immunoresponse and this response is not influenced by sex. According to our results, we would propose the administration of a single booster dose 10 years after primary vaccination and thus protect these subjects during the period of greatest risk.

Child↗

[Coverage and immune response to systematic hepatitis B vaccination in preadolescents of the city of Elche].

OBJECTIVE: To know the coverage of the systematic program of hepatitis B vaccination in the population of 7th year primary school children (12 years old) in the city of Elche. To investigate the immune response to the vaccine, and the length of protection according to this response. To study the relationship between the immune response and other biological variables such as height, weight, Quetelet index and sex. DESIGN: Cross-sectional study. SETTING: In a school community. PARTICIPANTS: The first five students of 7th in all the official class lists (110) from each school (53) were selected. The immune response was studied in 427 students. MAIN RESULTS: The 84.36 +/- 4 were correctly vaccinated (95 percent confidence level). A month after the booster dose, the antibodies HBs titres were quantified, considering levels of protection > or = 10 mU/ml. We found that Quetelet index and the antibody response were inversely correlated (p = 0.015). Sex was not a significant predictor of lack of detectable antibody response. 100% of correctly vaccinated children reached protective titres of antibodies, and 54% of them would be protected for 9 years or more. CONCLUSIONS: We consider the coverage satisfactory and excellent the seroprotection that this vaccine offers to these children. We suggest, to this population, a booster dose 10 years after the first vaccination.

Age Factors↗

[Epidemiology of caries in Alicante preschoolers. 2. Risk factors].

An epidemiological study of dental caries amongst preschoolers (aged between 4 and 6 years) from the city of Alicante has been carried out. The influence of the socioeconomic class as well as higienic and diet habits on the appearance dental caries of deciduous teeth has been evaluated. From a total population 7,289 preschoolers, a representative sample of 1,292 children was obtained by the sampling process of a stratified randomization. A statistical significant association was found between socioeconomic class and dental caries (p less than or equal to 0.05), being the lower classes the more prone to dental caries. Higienic habits of the examined children were clearly inadequate; 75.62% of preschoolers showing dental plaque. There was a statistical significant relationship between dental plaque and caries (p less than or equal to 0.05). The ingestion of candies has been shown to be also related with dental caries. Those children who never eat candies showed a prevalence of dental caries of 30.84%, whereas the prevalence increased up to 44% in cases of frequent ingestion of sugared food.

Candy↗