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M Pedroza

Publications and source records attributed to M Pedroza.

4 recordsLinked to original sources
PubMed1999

Strong association of HLA class II sequences in Mexicans with Vogt-Koyanagi-Harada's disease.

Vogt-Koyanagi-Harada's syndrome (VKH) is an autoimmune disease prevalent in Mongoloids with evident participation of HLA. The aim of this study was to identify the class II DNA sequences involved in the etiopathogenesis of VKH in Mexican Mestizos. This study included 46 VKH patients and 170 controls. 75% were females (mean age at onset of 33.5 years). The disease evolved to chronicity (68%) and 25% of the patients were unresponsive to corticotherapy. DNA typing of HLA-DRB1, DQA1 and DQB1 was done following the 12th International Histocompatibility protocols. VKH was strongly dependent of DRB1 gene; DRB1*04 was found in 78.2% of the patients vs. 50.6% of the controls (p = 0.001). No particular DRB*04 subtype was significantly increased, suggesting that residues E-9 V-11; H-13; H-33 and Y-37 shared by all DR4s are implicated in susceptibility to VKH. However DRB1*0101 (p = 0.009, OR = 4.2) was clearly associated. This allele shares the motif LLEQRRAAG located at position 67-74 and 86 of DRB1 with *0405 associated in Japanese. Two HLA associated mechanisms may be triggering the autoimmune phenomena. One involving critical polymorphic residues expressed in different alleles. Secondly, some peptides may anchor to the conserved residues leaving other sequences to bind to the T cell receptor.

Adult↗
PubMedDate not supplied

[Challenges for developing a comparative analytical model for health services].

This paper presents different models that describe health determinants, services, and systems. It highlights the important model developed by Contandriopoulos, proposing a separation between the health status and health care circuits. The article is intended as a contribution to the field of comparative analysis with a new theoretical, methodological, and evaluative approach. Problems were identified in the development of a new model. Decentralization and access are introduced as categories, suggesting that they may take part in such new model.

Health Services↗
PubMedDate not supplied

[Effect of streptococcal products in the induction of antibodies against cardiac sarcolemma].

It has been pointed out in rheumatic fever that the extracellular products of streptococcus (EPS) induce an immune response capable of producing autoimmunity against cardiac structures. In an experimental model in rats, the possibility that EPS facilitates the production of antisarcolemma antibodies was analyzed by injecting the animals with EPS, or simultaneously with EPS and human heart sarcolemma (HHS). The rat sera was analyzed by microdouble immunodiffusion against EPS, HHS or a mixture of both, the rats immunized with HHS or with EPS and HHS produced anti-HHS antibodies. The average of precipitation bands increased with the number of immunizations. Under the experimental conditions used, the humoral immune response against HHS was not modified by EPS and also EPS alone did not induce antibodies against sarcolemma. The synthesis of antibodies to EPS was very low or Null. The antiestreptolysin-O levels were low during the immunization period. A minimal inspecific myocarditis with lymphocytic inflammatory infiltrate was induced. The humoral immune response against cardiac sarcolemma and against the extracellular products of streptococcus was similar in the groups of rats studied, independently of sex, weight, age, dose, inoculation method or immunization time in accordance with schemes used in this work.

Animals↗