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Biomedical subjects

M Perol

Publications and source records attributed to M Perol.

44 records · Page 3Linked to original sources
PubMed1991

[A predominant manifestation of pleural cryptococcosis in acquired immunodeficiency syndrome].

Systemic cryptococcosis occurs in at least 6% patients with human immunodeficiency virus infection (HIV). The lung infection by cryptococcus neoformans, less frequently observed than meningeal involvement, consists usually in focal parenchymal mycosis. Authors report an apparently isolated pleural cryptococcosis in a 41 years old mal with HIV infection. Diagnosis was performed initially by pleural and bronchial alveolar lavage (BAL) fluid culture. Characteristic cryptococcosis pathological and histologic findings from thoracoscopy and open pleural biopsy are described. Cryptococcus capsular polysaccharides stainings and thoracoscopy interests are emphasized.

Adult↗
PubMed1990

[Bronchospasm disclosing pulmonary embolism].

We report the case of an 82-year old male patient without history of chronic obstructive lung disease in whom a sudden respiratory distress syndrome with sibilant rales in both lungs revealed a moderately severe pulmonary embolism, later confirmed by angiography. Bronchospasm occurring in the acute phase of pulmonary embolism may be expressed as acute asthma refractory to bronchodilators. This bronchoconstriction, seldom detectable clinically, seems to be related to regional alveolar hypocapnia in the territories embolized and to platelet-produced mediators, through a vagus nerve-mediated reflex. It must not hide pulmonary embolism, particularly in a suggestive context and when bronchodilators are ineffective.

Aged↗
PubMed1990

[Bronchial tuberculosis. Report of 4 cases].

Four cases of bronchial tuberculosis are reported. The first case was revealed by signs of bronchitis; in the second patient M. tuberculosis was found at light microscopy but x-ray films of the chest were normal; the third patient presented with signs of bronchitis and upper lobe infiltration on fibrous sequelae; the fourth patient showed a pseudo-tumoral bronchial image. These cases and those of the literature show that clinical signs are usually those of bronchitis sometimes with the systemic symptoms of tuberculosis. Chest radiography may be normal or may display disorders of ventilation of lung opacities suggestive of recent tuberculosis. Endoscopy reveals granular inflammation with whitish secretion and progressive stenosis. Diagnosis rests on bacteriological and pathological examinations. Medical treatment does not differ from the standard one. Sequelae consisting of bronchial stenosis or bronchiestasis are extremely frequent. Bronchial tuberculosis is now seldom encountered and usually affects elderly women. However, it may now become more frequent due to the greater number of cases of tuberculosis with a slightly atypical course, as found in AIDS patients.

Aged↗
PubMed1990

[A rare cause of pleurisy from subdiaphragmatic origin: epidermoid cyst of the spleen].

Subdiaphragmatic diseases are a classical but uncommon cause of pleural effusion. We report here the case of a woman admitted for a left pleural effusion which led to the discovery of a splenic tumour. Pathological examination of the splenectomy specimen showed that the tumour was an epidermoid cyst of the spleen. Cysts of the spleen are exceptionally revealed by pleurisy. Epidermoid cysts account for 10% of all non-parasitic splenic cysts. They remain silent for a long time and are usually disclosed by such complications as compression of surrounding organs, rupture or superinfection.

Adult↗
PubMed1989

[Lipid pneumopathy caused by occupational exposure to cutting oil].

This is a case report of a diffuse interstitial pneumonia which developed rapidly in a 45-year-old patient who was occupationally exposed to regular inhalations of motor oil spray. The diagnosis of lipid pneumonia was based on a lung biopsy carried out by thoracoscopy. The biochemical analysis of the lipid extracted from the alveolar lavage and of the pleural liquid showed the presence of hydrocarbons, which were analogous to those found in motor oil and the strippings that were used. The subsequent progress without treatment after removal from the risk showed a partial regression of the radiological abnormalities. The incidence of occupational pneumonia to mineral oils is relatively low when the frequency of exposure is taken into account: objective data on the extent and the nature of exposure are often incomplete in published observations. The occurrence of respiratory symptoms or radiological changes in exposed subjects requires, nevertheless, a search for a possible lipid pneumonia. The diagnosis rests on a biochemical and cytological analysis of the alveolar liquid and on a lung biopsy.

Biopsy↗
PubMed1978

["Small cell" carcinoma of the lung. Results obtained using combination chemotherapy (adriamycin, vincristine, cyclophosphamide) in 38 patients (author's transl)].

A cyclic and sequential combination of adriamycin, vincristine (or VM 26) and cyclophosphamide was used, with a follow up of 4 to 33 months in 38 patients with a "micro-cellular" carcinoma of the lung. Radiotherapy was used in association in a variable manner. Chemotherapy alone resulted in marked regression of the lesions (regression is greater than 50%) in approximately 65 per cent of cases and a level of complete regression which varied from 31 to 45 per cent according to the degree of diffusion of the lesions at the time of admission. In this study, survival in apparently localised forms was 70 per cent after one year and 55 per cent at eighteen months, whilst it was 34 per cent at one year and nil at eighteen months in patients with evidence of metastatic disease at the time of entry. These encouraging results indicate a hope for improvement, in certain patients reacting favourably to this protocol, in the still grave prognosis of "small cell" carcinoma of the lung.

Adult↗