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Biomedical subjects

M Perrin-Fayolle

Publications and source records attributed to M Perrin-Fayolle.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Chiasmal radionecrosis after irradiation of the sella turcica using a conventional dosage. Contribution of magnetic resonance imaging].

A 47 year-old man developed rapid visual loss, visual field defects and memory disturbances after radiotherapy with conventional doses for a pituitary metastasis from a renal carcinoma. CT and MRI did not show recurrent tumour, pituitary apoplexy or empty sella. Eventually, T2-weighted MRI images showed abnormal high signals in the optic chiasm, the left mesial temporal lobe and the right inferior frontal lobe, supporting the diagnosis of delayed radionecrosis. The role of chemotherapy associated with radiotherapy is discussed.

Female↗
PubMed1989

Long-term results of surgical treatment for gastroesophageal reflux in asthmatic patients.

We report the long-term results of surgical repair of gastroesophageal reflux in 44 asthmatic patients who underwent surgery more than five years earlier (mean = 7.9 +/- 1.5 years). The severe asthma was associated with clinically evident reflux, and repair was attempted by surgical technique Nissen transabdominal gastropexy, with the following results: total cure, 11 cases (25 percent); marked improvement, 7 (16 percent); moderate improvement, 11 (25 percent); no improvement, 15 (34 percent). Cure was attained in intrinsic asthma with a predominance of nocturnal crises, associated with nocturnal tracheitis and with significant reflux, objective signs of which had appeared before the beginning of the asthma. Other results concerned asthmas complicated secondarily by GER in which it was impossible to determine whether the reflux was only a complication, without effect on the respiratory illness, or exacerbating the asthma. The question of surgery in these patients should be considered with care, being reserved for cases of severe asthma, poorly controlled by antiasthmatic drugs, and complicated by a severe reflux that encompasses ulcerative esophagitis.

Asthma↗
PubMed1989

[Metachronous primary pulmonary cancers. Apropos of a new case report].

The appearance of a second primary lung cancer more than four months after the initial cancer is called a metachronous cancer (as opposed to a synchronous cancer). We provide a case report of an epidermoid carcinoma coming more than three years after the initial diagnosis of an anaplastic small cell cancer of the lung. This second cancer developed in a different territory from the initial lesion. Amongst the hypotheses proposed chemotherapy may through an oncogenic action favour the appearance of a new type of cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1989

[Karyotype study of blood lymphocytes in sarcoidosis].

Among 31 patients presenting with pulmonary sarcoidosis, two had abnormalities of their blood lymphocyte karyotypes. The karyotype of the first patient showed an initially high percentage of non-specifically broken chromosomes. The second patient, who had been treated with azathioprine (AZ) one year previously, had an apparently balanced translocation 46 XX, t (11; 11) (p 12, p 14) in blood T lymphocytes but not in skin fibroblast culture. Various hypotheses can be discussed to explain this translocation: a direct toxic effect of AZ or a genomic abnormality depending upon sarcoidosis and possibly revealed by AZ. It is important to note that this translocation concerned a region of the short arm of chromosome 11, where Harvey ras I and parathormone genes have been located.

Adolescent↗
PubMed1989

[Bronchial hyperreactivity in the asthmatic and its prevention].

The author reports successively: A summary of our present knowledge concerning bronchial hyperreactivity etiology. Secondly, three kinds of actions which prevent the onset and progression of BHR. These are: prophylaxis, preventive measures against etiological factors, therapeutic decisions after critical analysis of the activity of BHR of antiasthmatic drugs.

Air Pollutants↗
PubMed1988

[A simple test for the detection of respiratory allergy to current pneumallergens].

Phadiatop is a new in vitro test used for screening patients with allergic respiratory diseases. This test, based on the RAST procedure, is performed with a paper disc to which a balanced mixture of relevant inhalant allergens has been coupled. One hundred and one adults ranging in age from 18 years to 73 years and 38 children (4 months to 15 years) were studied. We found a good correlation between this new test and total IgE (adults: 74.3 p. 100, children: 68.4 p. 100), specific IgE (adults: 91.1 p. 100, children: 100 p. 100) and skin test (adults: 79.2 p. 100, children: 97.1 p. 100). There was a high correlation between clinical atopy assessment and the result of Phadiatop, its efficiency was 83 p. 100 in adults and 97 p. 100 in children.

Adolescent↗
PubMed1988

[Asthma and gastroesophageal reflux].

The authors review the now well-established data that concerns the relationship between asthma and gastro-oesophageal reflux (GER). These include the high frequency of the association in severe asthma, the diagnostic procedure of GER in asthmatics and the significance of reflux in these patients (reflux that causes asthma or reflux that is secondary to asthma). Then the mechanism of the action of GER on asthma are discussed. In the second part the authors summarise the following issues, that are only partly resolved. Evaluation of the possible worsening effect of GER on the symptoms of asthma. They insist in particular on the valuable contribution of clinical data and the results of the Bernstein acid infusion test. Therapeutic indications, particularly those for surgical correction. Recent results from a long term study of surgical treatment of 46 patients are presented.

Asthma↗
PubMed1987

Phosphatidylethanolamine methyltransferase and cAMP, cGMP phosphodiesterases in lymphocytes and monocytes in sarcoidosis.

Among the various hypotheses proposed to explain immune cell defect in sarcoidosis, we examined thoroughly that of Faguet who described abnormalities of signal transmission at lymphocyte membrane level. Phosphatidylethanolamine methyltransferase and cAMP cGMP phosphodiesterases were studied in blood lymphocytes and monocytes from 8 subjects with sarcoidosis disease. Phosphatidylethanolamine methyltransferase (PMT1) plays an important regulatory role in membrane signal transmission. cAMP and cGMP phosphodiesterases (PDE) regulate cytoplasmic cyclic nucleotide levels and so participate in the modulation of the cell cycle. We observed a decreased PMT1 activity in lymphocytes and monocytes and a decreased cAMP and cGMP PDE activities in monocytes. It is not now possible to say if these abnormalities are primary or secondary. Whatever the origin of this dysfunctioning, these results evoke simultaneous disturbances of membrane signal transmission and cell cycle in monocytes and membrane abnormalities in lymphocytes. These abnormalities could explain some immune cell defects in sarcoidosis disease.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMed1987

[Comparative study of various technics for measuring serum IgE levels].

In this work we report the results of a comparative study of different techniques to measure specific IgE in sera. Three methods were used, Phadebas RAST, Phadezym RAST (PHARMACIA) and allergen-specific FAST+ test (3M DIAGNOSTICS): 127 sera were tested with several pneumoallergens (housedust, Dermatophagoides pteronyssinus, Dactylis glomerata pollen, cat and dog hair). Analysis of the results shows the following correlations: Phadebas and Phadezym RAST 92%; Phadebas RAST and FAST+ 88%; Phadezym RAST and FAST+ 67%; Furthermore, the responses vary according to the allergen. The FAST+ system seems to be more sensitive than the RAST. The RAST must remain the reference method, but it should always be remembered that the different techniques for measurement of specific IgE have their own fields of application.

Allergens↗
PubMed1987

[Asthma and gastroesophageal reflux].

This work summarises present-day knowledge concerning relationships between asthma and gastro oesophageal reflux (GOR). The data acquired during the last ten years are briefly reviewed. They concern: the high frequency of GOR during asthmatic disease, the clinical signs which allow one to suspect such a possibility, the significance of these refluxes, and their provocative factors (mechanical, iatrogenic, and neurogenic). In the second part, the author exposes various problems which have not yet been absolutely solved. They concern: the methods of diagnosis of GOR (prolonged pH measurements and isotopic explorations seem to be the best techniques) and the question of management concerning the latter problem medical treatment of reflux should be widely prescribed. Surgical indications however, should on the contrary be carefully discussed.

Adult↗
PubMed1987

[Purulent pleurisy due to Legionella bozemanii].

Since the advent of antibiotics, the bacteriological profile of empyema has changed. It is necessary to recall the recently discovered organisms. Although rarely mentioned in the literature, the Legionnellas may be causative in an empyema. We report a case of empyema to Legionnella bozemanii proven seriologically.

Antibodies, Bacterial↗
PubMed1987

[Tracheobronchial lipomatosis. Apropos of a case].

A case of tracheo-bronchial lipomatosis is reported. Bronchial lipomas are benign fatty tumours which frequently result in bronchial superinfection or dyspnoea. The radiological image is often one of atelectasis, and the diagnosis is made at endoscopy. Treatment, rendered necessary by destruction of the underlying lung, is either endoscopic or surgical. Multiple localizations are exceptional and raise special therapeutic problems.

Bronchial Neoplasms↗
PubMed1986

Production of the angiotensin converting enzyme (ACE) in cultures of rat peritoneal macrophages.

Some authors attributed an increase in ACE activity in sarcoidosis to high production of this enzyme by alveolar macrophages. In order to study the production of ACE by peritoneal rat macrophages, we measured the ACE activity, by a modified version of Friedland and Silverstein's technique, in cultures of rat peritoneal macrophages, with dexamethasone, with Complete Freund Adjuvent (C.F.A.) or sarcoidosis node extract (Kveim Antigen). ACE activity was not detected in cultures. Our results were discussed.

Animals↗
PubMed1986

[Methylation of membrane phospholipids of alveolar macrophages in pulmonary sarcoidosis and diffuse interstitial pulmonary fibrosis].

Alveolar macrophage plays an important role in alveolitis pathogenesis and lung fibrosis process. Macrophages exhibit plasmic membrane biochemical modifications during cell activation. Phospholipid methylation is involved during plasmic membrane stimulation. Phosphatidylethanolamine methyltransferase I was measured in alveolar macrophage membrane from normal subjects and patients presenting with pulmonary sarcoidosis or interstitial lung fibrosis. We observed increased enzyme activity among sarcoidosis subjects with high intensity lung alveolitis and normal subjects receiving immunostimulating treatment (RU 41740). The role of membrane phospholipidic modifications in granulomatous process is discussed.

Adolescent↗