Biomedical subjects
M Perry
Publications and source records attributed to M Perry.
Pituitary arylamidases and peptidases.
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The woolly opossum--a new research tool for cytogenetic studies.
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The relationship between insulin sensitivity and skeletal muscle enzyme activities in hepatic cirrhosis.
We have examined the hypothesis that insulin insensitivity in hepatic cirrhosis is related to abnormalities of glycogen deposition and skeletal muscle enzyme activities. Otherwise well patients with biopsy-proven hepatic cirrhosis secondary to previous excess alcohol intake were studied. Prior to study, in basal state, patients had identical blood glucose concentrations but raised serum insulin concentrations (cirrhotic: 8.5 +/- 0.8 mU per liter; matched control subjects: 5.7 +/- 0.5 mU per liter, p less than 0.01). Muscle glycogen content, glycogen synthase activity and pyruvate dehydrogenase activity were normal in the basal state. The cirrhotic patients required less glucose to maintain the clamp in response to 0.1 unit per kg per hr insulin (6.7 +/- 0.5 vs. control 8.3 +/- 0.4 mg per kg per min, p less than 0.05) and deposited less glycogen in muscle during the clamp (8.6 +/- 0.5 vs. 12.0 +/- 1.4 mg per gm protein, p less than 0.05). Glycogen deposition correlated with clamp glucose requirement in the cirrhotic patients (r = 0.78, p less than 0.05). The expressed activity of glycogen synthase activity was significantly lower in cirrhotic patients at the end of the clamp (26.5 +/- 1.1% vs. 30.9 +/- 1.6%) and again correlated with clamp glucose requirement (r = 0.82, p less than 0.05). Skeletal muscle pyruvate dehydrogenase activity was not different in patients and control subjects. Insulin insensitivity in hepatic cirrhosis appears to be related to abnormalities of glucose deposition as glycogen in skeletal muscle.
Love and Haight: the sensuous hippie revisited. Drug/sex practices in San Francisco, 1980-81.
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Learning disabilities: community nutrition.
Nutrition for people with learning disabilities living in the community is an aspect of care that should not be taken for granted. From clients who live virtually independently to those living in fully staffed homes, there is much to be gained from a thorough assessment of their eating patterns. This article reviews the most common nutritional problems such clients face and discusses ways of overcoming them.
Preceptorship in clinical nursing education: a social learning theory approach.
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Treating obesity in people with learning disabilities.
Obesity in people with learning disabilities should not be dismissed as untreatable. Such people have the same right to a healthy weight as the rest of the population. Equally, they should have the right to remain overweight if they so choose, provided their choice is an informed one. This paper reviews the reasons people with learning disabilities may become obese, addresses how this problem may be tackled and highlights some of the ethical issues involved in weight reduction for this client group.