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Biomedical subjects

M Pesek

Publications and source records attributed to M Pesek.

At least 19 recordsLinked to original sources
PubMed1994

[Survival after surgery for bronchogenic carcinoma in relation to blood transfusion].

The authors observed 143 patients operated on for lung cancer over a period of five years. In 85 patients, who received a blood transfusion, the authors evaluated the relationship between the amount of blood transfused at the time before and after the operation and the localisation and TNM classification of the tumour, the operative procedure and the age of the patient. In a detailed statistical analysis the authors evaluated the long-term survival rates of patients with and without blood transfusions. Surprisingly, there were no essential differences in the amount of blood transfused, neither in various localisations of the tumour nor in the variously advanced T, N, M stages nor in the most frequent technical complications during surgery. All the 16 patient who received more than 1000 ml of blood died within 18 months after the operation. In spite of this fact the authors were not able to prove statistically significant differences in the long-term survival of patients with and without blood transfusion.

Adult↗
PubMed1990

[Adjuvant therapy of lung cancer].

The authors evaluated in a retrospective investigation the effectiveness of adjuvant postoperative chemotherapy (ChT) and radiotherapy (RT), as compared with surgery alone, according to morphological types and stages of cancer lung (CaP). In a group of 321 patients 143 were treated by operation alone, 36 by operation and RT and 53 by operation and ChT. ChT involved administration of Cyclophosphamide, 30 mg/kg, at three-week intervals, some of the patients were also given vincaalkaloids. Therapy was repeated after 6-month intervals. According to the gross mortality data the probability of survival (PP) was compared by Kaplan-Meier's method. Improved PP was proved in patients with small cell lung cancer (MbCa) treated by operation and ChT and in third-stage disease treated by adjuvant ChT. In stage I of CaP adjuvant ChT and RT cause deterioration of the perspective of survival, as compared with operation alone and in stage II adjuvant ChT and RT are no advantage. The authors recommend adjuvant ChT in patients with surgically treated small-cell carcinoma and in stage III of operated CaP. They draw attention to the different response of tumours to adjuvant ChT and RT according to types and stages of CaP, to the fact that RT does not prolong the survival and to the possibility of preoperative ChT and RT in some types and stages of CaP.

Combined Modality Therapy↗
PubMed1990

[Cryocoagulation in the treatment of bronchial tumors].

From 1987 to 1989 22 men and one woman with morphologically certified tumors of the lungs were symptomatically treated with cryocoagulation. The cryoequipment KNF 4/5 with 30 W freezing capacity was used. After treatment in 20 out of 22 patients an objective improvement could be observed. A significant increase of spirographically measured vital capacity was found. Control observations of the results after treatment using a densitographic investigation of the regional distribution of the ventilation included the advantage that valuable informations concerning the effect of the treatment were received without further burden for the patient.

Adenocarcinoma↗
PubMed1990

[Effectiveness and reliability of preoperative studies in patients with lung cancer].

The data of documentation of 267 operatively treated patients with lung cancer are shown in a retrospective study. The patients were treated in the clinic for tuberculosis and respiratory diseases of the faculty hospital Plzen. In 50% of the cases the results of histological and cytological examinations correspond with the surgical observations. Results of the pneumomediastinography and the computed tomography of the lung and mediastinum correspond with findings through the operation in 71% and 73% respectively. Through out the last three years the reliability of the cytological diagnosis was increased significantly (p less than 0.01).

Biopsy↗
PubMed1989

[Results of surgical treatment of pulmonary carcinoma in patients over 60 years of age].

The authors submit an analysis of patients operated in 1972-1982 at the First Surgical Clinic, Faculty of General Medicine, Charles University Prague. The group of patients was divided into those under 65 years and those above this age. The effect of the patients' age on the postoperative course was investigated, the survival of the two groups was compared, the causes of early postoperative deaths, the extent of the disease and histological type of tumour were evaluated. In was revealed that the risk of early postoperative death within one month is greater in patients above 65 years where it is 19.6%, as compared with 11.3% in the younger group. The risk increases in particular in patients above 70 years where it is as high as 26%. There is no fundamental difference in the causes of death between the two groups. The highest percentage of operated patients dies from embolism (40% and 42% in the patients above 65 years), the second place is held by inflammatory pulmonary complications which are somewhat more frequent in patients of the younger age group (24% as compared with 15% in the older patients). The survival curves of patients who had a radical operation in stage I and II of the neoplastic disease are almost identical and there is no significant difference in the survival of the two groups. In the group under 65 years 30% survive five years, in the older group 25%. The ratio of differentiated types of lung cancer, i.e. adenocarcinoma and epidermoid carcinoma is equal in both groups, contrary to small-cell carcinoma which was recorded in 6% in the older patients, as compared with 15% in the younger ones.

Age Factors↗
PubMed1987

Lung cancer growing around a silicotic nodule.

The authors report on a patient, working for 17 years in ceramic industry, in whom simple silicosis was revealed in 1977. In 1985 the disease progressed and a nodule-like opacity in the left upper lung lobe was detected. After one year of further progression cavitation was found. Suspected cancer was confirmed cytologically by discovering epidermoid cancer cells in the lavage from the growing around the silicotic nodule. Lobectomy was performed, the postoperative course being without complications.

Aged↗
PubMed1987

Diagnosis and treatment of mediastinal cyst using transparietal needle aspiration.

The authors present a case report on a 60-year-old female patient suffering from benign mediastinal cyst, arterial hypertension and porphyria. CT-guided transparietal fine-needle punction was done simultaneously as a diagnostic and a therapeutic procedure. Partial regression of the cyst was still apparent at the check CT investigation after six months. The examination of the level of immunoglobulins in the fluid obtained during transparietal punction confirms the diagnosis of bronchogenic cyst.

Biopsy, Needle↗