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Biomedical subjects

M Petronijević

Publications and source records attributed to M Petronijević.

7 recordsLinked to original sources
PubMed2006

[Acute renal failure after cesarean section as a consequence of hematoma of the retropubic space of Retzius].

Acute renal failure is rare postoperative complication of cesarean section. Postrenal acute renal failure is corectible ant it shoud be done immediately in order to avoid secundary destruction of renal parenchim. Surgical techniques shoud be directed to achieve adequat haemostasis, espetialy at low transverse Pfannenstiel incision, as well as in tender manipuliating with tissues to prevent unnecessery formation of dead space and tissues devitalisation. Authors are presenting the case of acute renal failure after cesarean section as a consequence of hematoma of the retropubic space of Retzius and way of treatment.

Acute Kidney Injury↗
PubMed2004

Galectin-1 and galectin-3 in the trophoblast of the gestational trophoblastic disease.

While the presence and distribution of galectin-1 and galectin-3 in different normal trophoblast cell populations is known, no information is available regarding their occurrence in malignant trophoblast of gestational trophoblastic disease (GTD). Galectins-1 and -3 have, however, been implicated in malignancies of other tissues. Immunoreactivity for these galectins in the transformed trophoblast of invasive mole (n = 8), choriocarcinoma (n = 7) and one case of placental site trophoblastic tumor (PSTT) was compared to that of the invasive trophoblast of the normal first trimester of pregnancy implantation sites (n = 9). A large proportion of the transformed trophoblast cells of all GTD studied were positive for galectin-1 and galectin-3. Immunoreactivity was scored semiquantitatively to include both the prevalence among the trophoblast cells and the intensity of staining. Immunoreactivity for both galectin-1 and galectin-3 in gestational trophoblastic disease is increased (significant differences at p < 0.05, Mann-Whitney Rank Sum Test). This finding may suggest a possible implication of galectins-1 and -3 in the invasiveness of the transformed trophoblastic cell, although the exact physiological significance of this finding remains to be determined.

Adult↗
PubMedDate not supplied

[Rational for the use of human immunoglobulins in clinical practice].

The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyvalent intravenous immunoglobulins in the clinical praxis". This paper summarizes the contemporary knowledge about the structure and biological activity of immunoglobulins, methods for their production, different pharmacokinetic and pharmacodynamic characteristics of two types (5S and 7S) IVIG preparations, etc. We pointed out three basic groups of indications for IVIG clinical use: 1) substitutional therapy in the primary and secondary immunodeficiencies; 2) adjuvant therapy for severe infections; 3) immunomodulation in autoimmune diseases. Particular emphasis was put on currently known mechanisms of immunosuppressive action of IVIG in autoimmune diseases. Except for presently accepted indications for their use (idiopathic thrombocytopenic purpura and Kawasaki syndrome) we mentioned about 40 different diseases in hematology, neurology, rheumatology and other branches of medicine, from neonatology to transplantology, in which IVIG had shown some efficacy. Possibilities of different therapeutic modalities and the choice of diverse pharmacokinetic and pharmacodynamic effects, benefit the very wide spectrum of diseases, while minimal incidence of adverse effects suggested them to be the therapy of the future in the clinical practice.

Humans↗
PubMedDate not supplied

Intravenous immunoglobulin preparations as immunomodulatory agents.

Certain immunopathologic conditions, such as hypersensitivity and autoimmune diseases, are characterized by quantitative and/or qualitative alterations of immune reactions. It is now believed that such immunologic disturbances generate from inadequate internal control and regulation of immunologic reactivity. Important member of the complex regulatory network that supervises an immune response are antibodies themselves. Since antibody is bifunctional molecule, its regulatory action deals with two separate molecular structures denoted as Fab and Fc portion. By Fab fragment, antibody interferes with the reaction with antigens, or participates in the regulatory idiotype/antiidiotype interactions. Fc-mediated regulation includes influence on complement activation cascade, formation and clearance of immune complexes, phagocytosis, ADCC activity, T- and B-cell function, cytokine profile, etc. In general, antibody triggers immune reactions, but also has the capacity to suppress them. Exogenous antibodies are likely to elicit similar effects on immune processes. Actually, it has been demonstrated that intravenously given immunoglobulins, particularly high-dose IgG, effectively combat harmful immune response in some chronic inflammatory and autoimmune disorders. Hence, preparations of immunoglobulins for intravenous use (IVIG) can be considered as an immunomodulatory agent. To achieve the property of modulating the immune response, IVIG products must contain intact (7S) IgG molecule and maintain sufficient concentrations in plasma.

Adjuvants, Immunologic↗