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Biomedical subjects

M Petrus

Publications and source records attributed to M Petrus.

At least 19 recordsLinked to original sources
PubMed2000

[Cellular response one year after extracapsular cataract extraction--comparison of regular and heparin surface modified PMMA intraocular lenses].

PURPOSE: To compare the heparin-surface-modified and the regular polymethylmethacrylate posterior chamber intraocular lenses regarding cellular reactions one year after extracapsular cataract extraction. MATERIAL AND METHODS: 62 patients of either sex, with senile cataract, without diabetes and any preoperative pathology of the eye, were included in the study. 30 patients received HSM PMMA PC IOL and 32 patients received unmodified PMMA PC IOL. All patients had a standard extracapsular cataract extraction. At the examination after one year the best corrected visual acuity was defined, anterior segment of the eye was evaluated biomicroscopically, cell deposits were assessed and the state of posterior capsule was noticed. RESULTS: One year postoperatively all patients in both groups had the best corrected visual acuity better than 0.5. Significantly fewer eyes with the HSM PMMA PC IOLs had cell deposits on the anterior surface of the lens (20% vs. 37.5%). The amount of cell deposits per patients was small. Irregularity of the pupil with presence of posterior synechias did not differ significantly between the groups. The percentage of patients with clear posterior capsule was greater in the group with implanted heparin-modified artificial lenses. CONCLUSION: The study suggests that heparin-surface-modified posterior intraocular lenses result in less postoperative cellular response observed one year after extracapsular cataract extraction.

Aged↗
PubMed1999

[Allergy to squid and acari in a child].

UNLABELLED: Anaphylactic reactions after consumption of squid by patients sensitized to house dust mites have been reported several times. CASE REPORT: A child allergic to dust mites developed an angioneurotic edema after eating squid. An immunoallergological assessment, including the prick test, labial test and IgE RAST revealed an allergy associated to both dust mites and squid. CONCLUSIONS: In light of the potential seriousness of anaphylactic reactions, parents of children allergic to dust mites and these children should be made aware of the increased risk of allergies to squid that they may face.

Acari↗
PubMed1999

[Cellular reactions after intraocular lens implantation].

The surgical trauma and the presence of the artificial lens in the eye causes inflammatory reactions. The cellular response is a result of 1) the breakdown of the blood-aqueous barrier, 2) foreign body reaction induced by lens material. The presence of cellular deposits (small, fibroblast-like, epithelioid, giant cells) on the surface of intraocular lenses is related to many factors such as surgical technique, risk factors of inflammation, postoperative treatment and the kind of lens material. The aim of this paper is to present contemporary knowledge about cytopathology of intraocular lenses and chances to improve the surface characteristic to avoid the adhesion of cells.

Anti-Inflammatory Agents↗
PubMed1997

[Allergy to snails and mites in children].

BACKGROUND: Anaphylactic reactions after consumption of snails by patients sensitized to house-dust mites have been reported several times. CASE REPORT: Two 8- and 10-year old children sensitized to house-dust mites developed Quincke's oedema after eating snails. Immunoallergologic investigations including pricks-test, labial test, IgE Rast confirmed associated allergy between snails and house dust mites. CONCLUSION: Considering the potential severity of anaphylactic reactions, it is necessary to warn children allergic to house dust mites and their parents about the high risk of associated allergy with snails.

Anaphylaxis↗
PubMed1996

[Turner's syndrome and isoforms of LH and FSH. Value of polyclonal enzymatic techniques].

BACKGROUND: The glycoproteic hormones, LH and FSH, circulate under heterogenous molecular forms, the isoforms. The more acidic isoforms of FSH are found in hypogonadic patients and a displacement towards the basic forms is observed during substitutive treatment. CASE REPORT: A 13 year-old girl with Turner syndrome was examined for pubertal delay. Ultrasonography failed to see both ovaries and endocrine investigations showed a type P1 response (LH-RH test using immunological method). Control of hormonal levels by a polyclonal immunoenzymatic method confirmed primary hypogonadism. CONCLUSIONS: Radioimmunological methods using monoclonal antibodies can underevaluate FSH and LH levels under circumstances in which the distribution of isoforms may vary. Discrepancy must lead to the measure of gonadotrophins using polyclonal immunoenzymatic methods.

Female↗
PubMed1996

[Asthma and intolerance to benzoates].

BACKGROUND: Some foods and drug additives may induce allergic reactions. CASE REPORT: A girl with a family history of asthma in both parents developed asthma in her early life. She was successfully given continuous bronchodilator therapy until the age of 7 years. At that time, she had more frequent and severe exacerbations (8 within 10 months) despite reinforced continuous treatment. Oral challenges with bisulfite and sodium benzoate, both additives abundantly ingested by the patient, revealed heightened sensitivity to administration of sodium benzoate. Avoidance of this additive was followed by complete and prolonged disappearance of episodes of coughing and wheezing. CONCLUSION: Adverse reactions to benzoate in this patient required avoidance of some drugs, some of those classically prescribed under the form of syrups in asthma.

Asthma↗
PubMed1991

[Early neurotoxicity of high-dose of methotrexate and tetrahydrobiopterin deficiency].

Transient neurologic dysfunction associated with high-dose methotrexate and citrovorum factor rescue (MTX-CF) has been previously reported. At the biochemical level, there are at least two important pathways in central nervous system metabolism which might be disturbed by MTX: MTX may deplete the cell of the de novo synthesis of purine nucleotides and thymidylate through its action on dihydrofolate reductase (DHFR), and also inhibit dihydropteridine reductase (DHPR), an enzyme maintaining the cofactor of phenylalanine-hydroxylase in its active tetrahydrogenated form (tetrahydrobiopterin), and hence interfere with the supply of the neurotransmitters derived from tyrosine and tryptophan. We describe such a neurologic disease in a patient with acute lymphoblastic leukemia (ALL) receiving chemotherapy. Significant increase in cerebrospinal fluid biopterins supports the hypothesis of an inhibition of dihydropteridine reductase by MTX, and provides additional suggestions in terms of etiology, diagnosis and treatment.

Biopterins↗
PubMed1990

[Iatrogenic Cushing syndrome in infants. Report of a case with dwarfism].

We report a case of iatrogenic Cushing syndrome with dwarfism (-6 SD) in an eight-month-old infant. The respective role of exposure to corticosteroids in utero (the mother took 30 mg prednisolone per day throughout pregnancy) and postnatally (oral prednisolone, prednisolone in breast milk, and betamethasone cream) is discussed. Two other features are pointed out, i.e. presence of a food allergy and favorable outcome under hydrocortisone therapy.

Adrenal Cortex Hormones↗
PubMed1990

[Cervical spondylodiscitis caused by Kingella kingae. Apropos of a case].

We report a new case of spondylodiscitis due to Kingella kingae in a 19-month-old infant who had torticollis as the first manifestation. The main characteristics of Kingella kingae infections are reviewed: frequency of ENT and joint localizations, slow course, difficult clinical and bacteriological diagnosis, and satisfactory susceptibility to antimicrobial agents.

Bacterial Infections↗
PubMed1990

[Delayed severe decompensation of leucinosis. Significance of emergency blood exchange transfusion. Apropos of 2 cases].

The observations of two gypsy cousins born to consanguineous parents and exhibiting classical leucinemia are reminders that severe, life-threatening ketotic decompensations may occur at any time. Emergency exchange-transfusions in these two children aged 3 and 5 years reversed the course of extremely severe attacks. Medium term evaluations showed very satisfactory neuropsychologic development in both children. Pathogenesis and prevention of such episodes are discussed.

Amino Acid Metabolism, Inborn Errors↗
PubMed1988

[Intrarectal clonazepam in children. Plasma and CSF levels].

Eleven children with seizures were treated with clonazepam by rectal route. Thirty minutes after the administration, the plasma (8 to 28 ng/ml) and CSF (0.9 to 2.26 ng/ml) levels were satisfactory and correlated with a good clinical result. Since the tolerance of the drug was excellent, clonazepam appears to be as useful as diazepam in the management of childhood seizures.

Administration, Rectal↗