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Biomedical subjects

M Piga

Publications and source records attributed to M Piga.

52 records · Page 3Linked to original sources
PubMedDate not supplied

Long-term follow-up of technetium articular index in rheumatoid arthritis patients during oral chrysotherapy: evidence of paradoxical behaviour.

The Technetium Articular Index (TcAI) is regarded as a parameter of local inflammation in rheumatoid arthritis (RA). We studied TcAI behaviour during 1-year chrysotherapy in a group of fifteen RA patients. In non-responders TcAI showed a gradual decrease up to the 6th month and a return to baseline values within the second semester of the follow-up; conversely, in response patients TcAI remained unchanged during the entire period of the study, thus showing a paradoxical behaviour probably depending on the recovery of normal physical ability and articular activity.

Administration, Oral↗
PubMedDate not supplied

Study of cerebral flow with radionuclide: 99mTc-pertechnetate transit times and curves.

The transit of intravenously injected 99mTc-pertechnetate in the cerebrovascular tree can be monitored in patients in a supine position by means of a computer-assisted gamma-camera. When programmed properly, time-activity curves of the tracer in the region to be studied can be displayed, i.e. internal carotid arteries, brain hemispheres, etc. The application of the modified gamma function to these curves is employed in order to more accurately define the transit and transfer times in this region. Thirtyseven patients with cerebrovascular disturbances were examined. In most cases asymmetrical cerebral perfusion and a significant difference between right and left transit and/or transfer times were noted.

Adolescent↗
PubMedDate not supplied

[An anesthetized anesthesiologist tells his experience of waking up accidentally during the operation].

We report the recollections of an anaesthesiologist who experienced urogenital surgery under balanced anaesthesia which was insufficient to prevent awareness during a part of the procedure. The patient was hard apprehensive before surgery and neither sedative nor amnesic drugs were done as premedication. He received an Innovar, thiopentone, suxamethonium, nitrous oxide/oxygen sequence for intubation. Awareness occurred not long after but before administration of isoflurane for maintenance. In that terrifying moments the patient was conscious without pain. According to him the worst aspect of the experience was desperately wanting to move or speak and being unable to do so. In the event of unexpected awareness, the anaesthesiologist must deal with the patient in an honest and forthright manner. Failure to do so lead to dire psychological consequences for the patient and expensive malpractice litigation for the anaesthesiologist.

Adult↗
PubMedDate not supplied

[Carbamate and organophosphate poisoning].

Carbamate and organophosphate poisoning is a well known toxicological problem in developing countries, but still has, even in industrialized ones, a high mortality rate and a frequent invalidating outcome. Serious problems especially arise from cardiac (toxic myocarditis, QT prolongation, and other ventricular arrhythmias), muscular (intermediate syndrome, OPIDN), and neuro-behavioral (regressive psychosis, cognitive, mnesic and perceptive alterations) sequelae. Such complications, caused by direct neuronal, cardiac, and muscular damage, sneaky appear immediately after resolution of cholinergic crisis. Early establishment of antidotal (atropine + oximes) and supportive therapy, while reducing duration and seriousness of cholinergic crisis, should increase survival rates. In order to improve "quoad valetudinem" prognosis, widespread use of benzodiazepines is still recommended: such drugs antagonize some central signs and symptoms of cholinergic attack insensitive to atropine (fasciculations, muscular spasms, seizures, anxiety, psychomotor agitation). Moreover, they attenuate neuronal, cardiac, and muscular damage, caused by cholinergic overstimulation, which is responsible for invalidating outcome.

Carbamates↗