[Static cytometry in the study of ploidy patterns and cellular kinetics in carcinoma of the breast].
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
M Pirrelli
Publications and source records attributed to M Pirrelli.
[An electro- and vectorcardiographic study of ventricular activation in scleroderma].
Electrical ventricular activation was studied by means of electrocardiogram and vectorcardiogram in 62 patients, 55 women and 7 men, affected by systemic sclerosis of average disease duration of 10.3 years. 45% of the patients showed the "diffused form" of the disease and 55% the "limited form". The vectorcardiogram showed some alterations of the ventricular activation in 55% of the recorded cases. The previous electrocardiogram found only 18%. The alterations, which are more frequent in the diffuse form than in the limited one, are the presence of loss of forces in septal, lateral or inferior or combined areas and intraventricular conduction disorders as complete and incomplete right bundle branch block, left anterior subdivision block, left posterior subdivision block, or combination between incomplete right bundle branch block and left anterior or posterior subdivision block. The vectorcardiogram was more sensitive than the electrocardiogram in showing loss of forces, also in patients with the limited form of systemic sclerosis, when the electrocardiogram was normal. Moreover the vectorcardiogram is helpful to identify left posterior subdivision block. The vectorcardiographic investigation seems to be a useful complement of the electrocardiogram especially for the identification of cases with myocardial involvement that is clinically silent.
Adult↗
[Non-invasive diagnosis of constrictive pericarditis].
Explore the source record for details and available documents.
Aged↗
P-170 glycoprotein expression in gastric and colorectal carcinomas and normal mucosa. An immunocytochemical study.
During the past few years it has become apparent that simultaneous resistance of tumour cells to a number of heterocyclic drugs (multidrug resistance) is often correlated with overexpression of a P-glycoprotein (P-gp or P-170). P-gp expression can be studied by molecular biology and immunohistochemical techniques. The latter provide a rapid, sensitive and specific screening method suitable for testing even a relatively small number of tumour cells like those obtained at biopsy. The aim of this study was to detect and localize the immunohistochemical expression of P-gp in normal and neoplastic gastrointestinal tissue using the Mab JSB-1 in formalin-fixed paraffin-embedded specimens. A particularly striking finding of our study was the consistent, prevalent higher expression of P-gp in the stomach than in the colon, with a higher percentage of immunostaining in normal than in neoplastic tissue. This is in agreement with the fact that not only is the prognosis known to be worse for stomach cancer, but also the response to treatment is lower. Further studies should be carried out to verify the possibility of making routine tests of this kind for the evaluation of multidrug resistance, to guide the selection of patients for treatment of cancer with chemotherapeutic drugs.
ATP Binding Cassette Transporter, Subfamily B, Mem↗
The immunohistochemical expression of cathepsin D in colorectal cancer.
It has been suggested that cathepsin D expression in stromal cells affects the prognosis of breast cancer. With reference to colon and breast cancer, this study verified cathepsin D immunostaining in epithelial and stromal cells of primary tumours and lymph-node metastases from 46 colorectal carcinomas. Eight of 46 cases (17%) were cathepsin D+ both in cancer and stromal cells. No staining was found either in cancer or stromal cells of the remaining cases. The results presented here suggest the possible paracrine influence of another diffusible factor produced by cancer cells which stimulates cathepsin D production in stromal and cancer cells.
Aged↗
A rare association between ovarian endometriosis and bilateral ovarian teratoma. Case report.
A 28 year woman complained for a sudden abdominal pain with some of the classical signs of the acute abdomen. Since a bilateral ovarian mass was found at ultrasound examination, clinician decided that patient underwent a urgent surgery. At histology, this mass resulted to be a bilateral triphillic mature teratoma. A focus lined by endometrioid epithelium and embedded in the modified stroma of endometrial type, was found beyond the residual cortex of the left ovary. There was some fibrotic tissue separating the endometrial and teratomatous lesions. To our knowledge, these two diseases have never been reported as associated in literature, but this association has a clinical relevance because an endometriotic pathology can reveal a silent teratoma with bilateral ovarian localization.
Adult↗